Comparative Effects of Nesiritide and Nitroglycerin on Renal Function, and Incidence of Renal Injury by Traditional and RIFLE Criteria in Acute Heart Failure

Ng, Tien M. H.; Ackerbauer, Kimberly; Hyderi, Alifiya F.; Hshieh, Shenche; Elkayam, Uri

doi:10.1177/1074248411406441

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…The renal actions of M‐ANP were significantly enhanced compared to NTG and occurred despite a significant reduction in BP. NTG did decrease RVR and this response is consistent with the elegant work of Elkayam who has demonstrated the potent renal vasodilating action of NTG in human HF . Unlike M‐ANP, the renovascular dilatation with NTG is unassociated with an increase in natriuresis, diuresis, or GFR .…”

Section: Discussionsupporting

confidence: 86%

“…NTG did decrease RVR and this response is consistent with the elegant work of Elkayam who has demonstrated the potent renal vasodilating action of NTG in human HF. 37,38 Unlike M-ANP, the renovascular dilatation with NTG is unassociated with an increase in natriuresis, diuresis, or GFR. 37,39,40 The renal actions of M-ANP most likely reflect GC-A receptor localization to the glomerulus and the renal tubule.…”

Section: Discussionmentioning

confidence: 99%

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M‐Atrial Natriuretic Peptide and Nitroglycerin in a Canine Model of Experimental Acute Hypertensive Heart Failure: Differential Actions of 2 cGMP Activating Therapeutics

McKie

Cataliotti

Ichiki

et al. 2014

JAHA

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BackgroundSystemic hypertension is a common characteristic in acute heart failure (HF). This increasingly recognized phenotype is commonly associated with renal dysfunction and there is an unmet need for renal enhancing therapies. In a canine model of HF and acute vasoconstrictive hypertension we characterized and compared the cardiorenal actions of M‐atrial natriuretic peptide (M‐ANP), a novel particulate guanylyl cyclase (pGC) activator, and nitroglycerin, a soluble guanylyl cyclase (sGC) activator.Methods and ResultsHF was induced by rapid RV pacing (180 beats per minute) for 10 days. On day 11, hypertension was induced by continuous angiotensin II infusion. We characterized the cardiorenal and humoral actions prior to, during, and following intravenous M‐ANP (n=7), nitroglycerin (n=7), and vehicle (n=7) infusion. Mean arterial pressure (MAP) was reduced by M‐ANP (139±4 to 118±3 mm Hg, P<0.05) and nitroglycerin (137±3 to 116±4 mm Hg, P<0.05); similar findings were recorded for pulmonary wedge pressure (PCWP) with M‐ANP (12±2 to 6±2 mm Hg, P<0.05) and nitroglycerin (12±1 to 6±1 mm Hg, P<0.05). M‐ANP enhanced renal function with significant increases (P<0.05) in glomerular filtration rate (38±4 to 53±5 mL/min), renal blood flow (132±18 to 236±23 mL/min), and natriuresis (11±4 to 689±37 mEq/min) and also inhibited aldosterone activation (32±3 to 23±2 ng/dL, P<0.05), whereas nitroglycerin had no significant (P>0.05) effects on these renal parameters or aldosterone activation.ConclusionsOur results advance the differential cardiorenal actions of pGC (M‐ANP) and sGC (nitroglycerin) mediated cGMP activation. These distinct renal and aldosterone modulating actions make M‐ANP an attractive therapeutic for HF with concomitant hypertension, where renal protection is a key therapeutic goal.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

M‐Atrial Natriuretic Peptide and Nitroglycerin in a Canine Model of Experimental Acute Hypertensive Heart Failure: Differential Actions of 2 cGMP Activating Therapeutics

McKie

Cataliotti

Ichiki

et al. 2014

JAHA

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“…Tests of BUN and blood Cr are typically used to assess renal function 26. Scald injury led to about a twofold increase in both BUN and blood Cr ( P < 0.05 relative to the sham group; Figs.…”

Section: Resultsmentioning

confidence: 98%

Protective effects of enalapril, an angiotensin‐converting enzyme inhibitor, on multiple organ damage following scald injury in rats

Zhang

Wang

Zhang

et al. 2012

Biotech and App Biochem

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The aim of this study is to investigate the effects of enalapril, an angiotensin-converting enzyme inhibitor, on multiple organ damage after scald injury. Healthy adult rats (half male and half female; 8-12 weeks old) were randomly assigned to the following treatments: sham operation, scald injury, and intraperitoneal enalapril (1, 2, and 4 mg/kg body weight) treatment after scalding. At 1, 12, and 24 H postscald, left ventricular and aortic hemodynamics were measured using a multichannel physiological recorder. Functional and pathological changes of the heart, liver, and kidney were examined by biochemical and histological methods. Compared with sham controls, untreated scalded animals showed decreased hemodynamic parameters and increased myocardial angiotensin II, serum creatine kinase heart isoenzyme, and serum cardiac troponin I and histopathological inflammation in the myocardium 12 H postscald. These hemodynamic, functional, and pathological changes were attenuated by 1 mg/kg enalapril. Enalapril reversed scald-induced elevations in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and blood creatinine 12 H postscald, and ameliorated focal necrosis in the liver and erythrocyte cast formation in renal tubules. However, higher doses of enalapril yielded less or no improvement in organ dysfunction. Enalapril at 1 mg/kg attenuates scald-induced multiple organ damage in rats.

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“…We read with interest the recent article by Ng et al that described no difference in the incidence of acute renal injury in patients with acute decompensated heart failure (HF) receiving either nitroglycerin or nesiritide. 1 On the other hand, their results suggested preservation of renal function by nesiritide. This prompted us to report our findings on the effect of periodic outpatient administration of nesiritide on renal function in patients with refractory HF unresponsive to optimal oral therapy.…”

mentioning

confidence: 97%

Effect of Intermittent Nesiritide Administration on Kidney Function

Sheikh-Taha

Zeitoun

2012

J Cardiovasc Pharmacol Ther

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Comparative Effects of Nesiritide and Nitroglycerin on Renal Function, and Incidence of Renal Injury by Traditional and RIFLE Criteria in Acute Heart Failure

Cited by 12 publications

References 21 publications

M‐Atrial Natriuretic Peptide and Nitroglycerin in a Canine Model of Experimental Acute Hypertensive Heart Failure: Differential Actions of 2 cGMP Activating Therapeutics

M‐Atrial Natriuretic Peptide and Nitroglycerin in a Canine Model of Experimental Acute Hypertensive Heart Failure: Differential Actions of 2 cGMP Activating Therapeutics

Protective effects of enalapril, an angiotensin‐converting enzyme inhibitor, on multiple organ damage following scald injury in rats

Effect of Intermittent Nesiritide Administration on Kidney Function

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