Comparative effects of monoamine oxidase inhibitors on monoamine oxidase and diamine oxidase

Shore, Parkhurst A.; Cohn, Victor

doi:10.1016/0006-2952(60)90012-5

Cited by 89 publications

(27 citation statements)

References 3 publications

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“…Cells were treated with polyamines and/or inhibitors 24 h after plating. In experiments where polyamines were added, the medium was supplemented with 1 mM aminoguanidine to inhibit serum amine oxidase [19].…”

Section: Methodsmentioning

confidence: 99%

Regulation of spermidine/spermine N¹‐acetyltransferase by intracellular polyamine pools

1993

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Through its role in polyamine acetylation and the back-conversion pathway, spermidine&ermine N'-acetyltransferase (SSAT) has the potential to control intracellular polyamine pools by facilitating their catabolism and/or excretion. The possibility that the enzyme is subject to regulation by intracellular polyamine pools was investigated in MALME3 human melanoma cells. Increases in intracellular polyamine pools by treatment with 3 PM exogenous spermidine or spermine for 48 h caused SSAT activity to increase 111% and 22696, respectively, and SSAT-specific mRNA to rise 19% and 6646, respectively. Decreases in polyamine pools by treatment with inhibitors of polyamine biosynthesis caused SSAT activity to decrease by 46% and mRNA to fall by 89%. Both SSAT activity and mRNA were more sensitive to changes in spermine than spermidine. The identification of a positive regulatory relationship between SSAT and intracellular polyamine pools further implicates this enzyme in a proposed model for polyamine pool homeostasis.

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Section: Methodsmentioning

confidence: 99%

Regulation of spermidine/spermine N¹‐acetyltransferase by intracellular polyamine pools

1993

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“…When the effect of bis(ethy1)polyamine analogues on cell growth was examined, 1 mM aminoguanidine, an inhibitor of amine oxidase in serum [14], was added to the medium.…”

Section: Cell Culture and Assays For Protein Synthesismentioning

confidence: 99%

Correlation between the inhibition of cell growth by bis(ethyl)polyamine analogues and the decrease in the function of mitochondria

Suzuki

Kashiwagi

et al. 1994

European Journal of Biochemistry

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The antiproliferating effect of nine kinds of bis(ethy1)polyamine analogues [three kinds each of bis(ethyl)triamine, bis(ethy1)tetraamine and bis(ethy1)pentaaminel was compared using FM3 A cells.The inhibitory effect was in the order BE4444 > BE3443 > BE4334ZBE444 > BE343 > BE333 > BE44 > BE34 > BE33. Our results indicate that not only polyamine deficiency but also the accumulation of polyamine analogues is involved in the inhibition of cell growth. Accumulation of bis(ethy1)polyamine analogues caused the inhibition of protein synthesis and the decrease in the ATP content. The protein synthetic system in mitochondria was more strongly inhibited by bis(ethy1)polyamine analogues than that in the cytoplasm. Under conditions such that cytoplasmic protein synthesis was inhibited by 50% by bis(ethy1)polyamine analogues, mitochondrial protein synthesis was almost completely inhibited. Mitochondria1 Ile-tRNA formation was inhibited by bis(ethy1)polyamine analogues at the concentrations that cytoplasmic Ile-tRNA formation was stimulated. This may be one of the reasons for the selective inhibition of mitochondrial protein synthesis. This inhibition was followed by the decrease in ATP content, swelling of mitochondria and depletion of mitochondrial DNA. These results suggest that the early event of metabolic change caused by bis(ethy1)polyamine analogues in cells is the inhibition of protein synthesis, especially of mitochondrial protein synthesis.Since the polyamines putrescine, spermidine and spermine are essential for the maintenance of eukaryotic cell proliferation [ 11, inhibitors of polyamine biosynthesis to deplete cellular polyamines have been developed as antiproliferative reagents [2, 31. Bis(ethy1)polyamine analogues have also been developed as antiproliferative reagents [4, 51. These reagents can not only negatively regulate the synthesis of omithine decarboxylase (OmDC) and S-adenosylmethionine decarboxylase (AdoMetDC) [6], but can also induce spermidinekpermine A"-acetyltransferase (SSAT) activity [7, 81. Thus, the analogues can deplete intracellular polyamines almost completely, and they are thought to inhibit cell growth through this process. We found that A", W'-bis(ethyl)spermine (BE343) can substitute for the functions of spermine in various aspects and accumulate in cells at a concentration fivefold that of spermine in control cells [9, lo], and suggested that not only polyamine deficiency but also the accumulation of BE343 may be involved in the inhibition of cell growth [lo]. Recently, it has been reported that the inhibition of cell growth by BE343 correlated with the intracellular acCorrespondence to K. Igarashi, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, Japan 263Fax: +81 43 290 2900. Abbreviations. OmDC, ornithine decarboxylase; AdoMetDC, S-adenosylmethionine decarboxylase; SSAT, spermidinehpermine W-acetyltransferase.Enzymes. Ornithine decarboxylase (EC 4.1.1.17) ; S-adenosylmethionine decarboxylase (EC 4.1.1.50) ; spermidinehpermine W-acetyltransferase...

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“…It has been shown that monoamine oxidase inhibitors, particularly those with the hydrazine moiety, interfere with enzyme systems other than monoamine oxidase, such as diamine oxidase, choline oxidase (Shore & Cohn, 1960;Burkard, Gey & Pletscher, 1960Gey, Pletscher & Burkard, 1963) and amphetamine oxidase (Fouts & Brodie, 1956). Thus it was not surprising that in rats pretreated with monoamine oxidase inhibitors intraportal injections of tyramine and amphetamine produced increased pressor responses.…”

Section: Pressor Responses In Pithed Ratsmentioning

confidence: 99%

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

Rand

Trinker

1968

British Journal of Pharmacology and Chemotherapy

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Comparative effects of monoamine oxidase inhibitors on monoamine oxidase and diamine oxidase

Cited by 89 publications

References 3 publications

Regulation of spermidine/spermine N¹‐acetyltransferase by intracellular polyamine pools

Regulation of spermidine/spermine N¹‐acetyltransferase by intracellular polyamine pools

Correlation between the inhibition of cell growth by bis(ethyl)polyamine analogues and the decrease in the function of mitochondria

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

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Comparative effects of monoamine oxidase inhibitors on monoamine oxidase and diamine oxidase

Cited by 89 publications

References 3 publications

Regulation of spermidine/spermine N1‐acetyltransferase by intracellular polyamine pools

Regulation of spermidine/spermine N1‐acetyltransferase by intracellular polyamine pools

Correlation between the inhibition of cell growth by bis(ethyl)polyamine analogues and the decrease in the function of mitochondria

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

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Regulation of spermidine/spermine N¹‐acetyltransferase by intracellular polyamine pools

Regulation of spermidine/spermine N¹‐acetyltransferase by intracellular polyamine pools