Comparative Effects of Intraduodenal Glucose and Fat Infusion on Blood Pressure and Heart Rate in Type 2 Diabetes

Xie, Cong; Wang, Xuyi; Jones, Karen L.; Sun, Zilin; Little, Tanya J.; Rayner, Christopher K.; Wu, Tong

doi:10.3389/fnut.2020.582314

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In “healthy” older individuals, intraduodenal administration of glucose (3 kcal/min) led to a more rapid decline in SBP when compared with intraduodenal isocaloric fat and protein [ 11 ], and the increase in superior mesenteric artery blood flow, a surrogate measure of splanchnic blood pooling, in response to intraduodenal protein was less when compared with glucose and fat [ 11 ]. In individuals with T2D, intraduodenal infusion of glucose (2 kcal/min), but not lipid, reduced diastolic blood pressure (DBP) [ 12 ]. The variable haemodynamic responses to macronutrients may reflect differences in neurohormonal profiles; for example, fat, relative to isocaloric glucose, is a more potent stimulus for secretion of the two incretin hormones, GLP-1 and GIP [ 12 , 13 ].…”

Section: Gastrointestinal Regulation Of Postprandial Blood Pressurementioning

confidence: 99%

“…In individuals with T2D, intraduodenal infusion of glucose (2 kcal/min), but not lipid, reduced diastolic blood pressure (DBP) [ 12 ]. The variable haemodynamic responses to macronutrients may reflect differences in neurohormonal profiles; for example, fat, relative to isocaloric glucose, is a more potent stimulus for secretion of the two incretin hormones, GLP-1 and GIP [ 12 , 13 ].…”

Section: Gastrointestinal Regulation Of Postprandial Blood Pressurementioning

confidence: 99%

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Potential for Gut Peptide-Based Therapy in Postprandial Hypotension

et al. 2021

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Postprandial hypotension (PPH) is an important and under-recognised disorder resulting from inadequate compensatory cardiovascular responses to meal-induced splanchnic blood pooling. Current approaches to management are suboptimal. Recent studies have established that the cardiovascular response to a meal is modulated profoundly by gastrointestinal factors, including the type and caloric content of ingested meals, rate of gastric emptying, and small intestinal transit and absorption of nutrients. The small intestine represents the major site of nutrient-gut interactions and associated neurohormonal responses, including secretion of glucagon-like peptide-1, glucose-dependent insulinotropic peptide and somatostatin, which exert pleotropic actions relevant to the postprandial haemodynamic profile. This review summarises knowledge relating to the role of these gut peptides in the cardiovascular response to a meal and their potential application to the management of PPH.

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Section: Gastrointestinal Regulation Of Postprandial Blood Pressurementioning

confidence: 99%

Section: Gastrointestinal Regulation Of Postprandial Blood Pressurementioning

confidence: 99%

Potential for Gut Peptide-Based Therapy in Postprandial Hypotension

et al. 2021

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Study on the effects of different postprandial positions on blood pressure and heart rate in older adults with primary hypertension and postprandial hypotension

Liu

Xiao

et al. 2022

Geriatric Nursing

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Postprandial Hypotension in Elderly Patients: Pathophysiology, Diagnosis and Prevention Measures

Antropova,

Efremushkina

2024

Arhivʺ vnutrennej mediciny

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Postprandial hypotension (PPH) is an important but underrecognized condition resulting from an inadequate compensatory cardiovascular response to meal-induced visceral blood pooling. PPG is recognized as an important clinical problem because it has a high prevalence in the older age group and is associated with the development of cardiovascular complications and geriatric syndromes. Possible pathophysiological mechanisms of PPG: increased visceral blood flow; weakening of baroreflex function due to disorders associated with age or autonomic dysfunction; inappropriate activation of sympathetic nerves; dysregulation of vasoactive intestinal peptides; insulin-mediated vasodilation. Ask about symptoms of postprandial hypotension and a decrease in systolic blood pressure (BP) of ≥20 mm Hg. Art. 15-60 minutes after eating is of paramount importance for making a diagnosis of PPG. One of the main strategies for preventing PPG is to reduce gastric distension (small meals and more frequent meals), resting on your back after eating, and drinking enough water. Walking after eating also appears to help restore blood pressure after eating. Caution should be exercised when prescribing protein supplements in the elderly, modifying the diet by replacing high-nutrient sweeteners with low-calorie sweeteners (d-xylose, xylitol, erythritol, maltose, maltodextrin, and tagatose). Metformin or acarbose modulates the cardiovascular response in patients with diabetes mellitus and reduces postprandial hypotension. Thus, PPG is a fairly common and clinically significant phenomenon in elderly patients. Increasing the awareness of doctors about pathophysiology and methods of diagnosis and prevention will improve the efficiency and safety of managing geriatric patients.

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Comparative Effects of Intraduodenal Glucose and Fat Infusion on Blood Pressure and Heart Rate in Type 2 Diabetes

Cited by 3 publications

References 18 publications

Potential for Gut Peptide-Based Therapy in Postprandial Hypotension

Potential for Gut Peptide-Based Therapy in Postprandial Hypotension

Study on the effects of different postprandial positions on blood pressure and heart rate in older adults with primary hypertension and postprandial hypotension

Postprandial Hypotension in Elderly Patients: Pathophysiology, Diagnosis and Prevention Measures

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