Comparative effects of implanted electrodes with differing contact patterns on peripheral nerve regeneration and functional recovery

Yu, Ai-Ping; Shen, Yi-Jie; Qiu, Yan‐Qun; Li, Jie; Shen, Yun-Dong; Wang, Xiaomin; Ma, Cong; He, Qianru; Chen, Qingzhong; Su, Jian

doi:10.1016/j.neures.2018.08.007

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…A study compared implanted electrodes with 4 kinds of contacts in the resected sciatic nerve (point contact; 1/4 circle contact; whole-circle contact; and no electrodes as control). They found that point contact has the same effect as the whole-circle contact (Yu et al, 2019). In this way, we can speculate that electroacupuncture (EA), as a kind of SQS, is a low-cost and valid therapy.…”

Section: Introductionmentioning

confidence: 83%

An ultrasound-guided percutaneous nerve stimulation regimen based on finite element modeling for median nerve rupture

Chu

Song

et al. 2021

Preprint

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Object: In order to promote the functional recovery of median nerve rupture patients, this paper proposes an ultrasound-guided percutaneous nerve stimulation regimen based on finite element modeling. Method: First, according to anatomy feature, a multi-layer human forearm model is constructed. What’s more, taking current density and activate function as optimization indicators, the percutaneous nerve stimulation regimen is designed with finite element modeling, including electrical needle angel, distance and position. Finally, to test the performance of designed regimen, a total of 22 patients with median nerve rupture participate in the clinical randomized controlled trial. And the clinical treatment effect is evaluated with BMRC, grip strength, functional score of median nerve and DASH scores. Results: The designed percutaneous nerve stimulation regimen is that, parallel to each other, electrical needles are located at both ends of the injury nerve with a distance of 3 cm. Besides, clinical trial results show that, after treatment the difference in sensory function was statistically significant. In terms of motor function, the BMRC of motor and grip strength are improved in both groups after treatment and there are significant differences between groups. Besides the grip strength improvement of experimental group is 4 times higher than that of control group. On global function, the DASH scores are reduced by 29% with experimental group but only 8% with control group; functional score of median nerve improved by 24% in the experimental group and by 22% in the control group, but the difference between groups is statistically significant after treatment. Conclusion: Clinical trial results demonstrate that the designed percutaneous nerve stimulation regimen can significantly improve the sensory, motor and global function of median nerve rupture, which is a potential clinical treatment regimen. Trial registration: ChiCTR, ChiCTR2000030790. Registered14 march 2020, http://www.chictr.org.cn/ChiCTR2000030790

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Section: Introductionmentioning

confidence: 83%

An ultrasound-guided percutaneous nerve stimulation regimen based on finite element modeling for median nerve rupture

Chu

Song

et al. 2021

Preprint

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“…Many studies have mentioned that the treatment of peripheral nerve injury by electrical stimulation has a good therapeutic effect. For example, Yu et al [ 22 ] found that electrical stimulation could enhance nerve regeneration and functional recovery, and the implementation of electrode point and 1/4 circle contact on the sciatic nerve resection model could significantly improve sciatic nerve function index, compound muscle action potential, and motor nerve conduction velocity scores and could better promote sciatic nerve regeneration and reduce muscle atrophy, with less mechanical damage to nerve trunk. Pan et al [ 23 ] studied that electrical stimulation could remarkably treat peripheral neuropathy caused by diabetes, reduce the apoptosis of sciatic nerve cells in diabetic rats, and prevent sciatic nerve injury by inhibiting the occurrence of endoplasmic reticulum stress.…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation Training Combined with Jiaji Electroacupuncture Can Promote the Recovery of Muscle Group Function and Improve the Quality of Life in Patients with Upper Limb Peripheral Nerve Injury

et al. 2021

Journal of Healthcare Engineering

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This study was designed to probe into the improvement of rehabilitation training combined with Jiaji electroacupuncture intervention on patients with upper limb peripheral nerve injury. A total of 114 patients with peripheral nerve injury of upper limbs in our hospital from August 2017 to November 2019 were collected as the research participants. Among them, 59 in the control group (CG) received rehabilitation training alone, while 65 in the observation group (OG) received rehabilitation training combined with Jiaji electroacupuncture intervention. The therapeutic efficacy, Barthel index, and Fugl–Meyer assessment score, motor nerve conduction velocity, sensory nerve conduction velocity and amplitude, and quality of life (score SF-36) were compared between the two groups before and after treatment. The total effective rate of the OG was markedly higher than that of the CG. After treatment, the Barthel index, Fugl–Meyer assessment score, motor nerve conduction velocity, and sensory nerve conduction velocity and amplitude of the OG were obviously higher than those of the CG, and the SF-36 scores of the OG were higher than those of the CG in 8 dimensions. Rehabilitation training combined with Jiaji electroacupuncture intervention can dramatically promote the recovery of muscle group function and improve the quality of life of patients with upper limb peripheral nerve injury.

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“…Electrodes with point contacts and 1/4 round contacts represent an effective alternative to portable electrical stimulation for the regeneration of the injured sciatic nerve and the reduction of subsequent muscle atrophy, which may provide a promising approach for the treatment of peripheral nerve injuries. 194 The use of implantable flexible stretchable devices has made significant progress in neuroregulatory therapy, but further research and clinical validation are still needed to ensure safety and efficacy.…”

Section: Application Of Flexible and Stretchable Implantable Devices ...mentioning

confidence: 99%

Flexible and stretchable implantable devices for peripheral neuromuscular electrophysiology

Li,

Zhao,

Song

et al. 2024

Nanoscale

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Comparative effects of implanted electrodes with differing contact patterns on peripheral nerve regeneration and functional recovery

Cited by 12 publications

References 32 publications

An ultrasound-guided percutaneous nerve stimulation regimen based on finite element modeling for median nerve rupture

An ultrasound-guided percutaneous nerve stimulation regimen based on finite element modeling for median nerve rupture

Rehabilitation Training Combined with Jiaji Electroacupuncture Can Promote the Recovery of Muscle Group Function and Improve the Quality of Life in Patients with Upper Limb Peripheral Nerve Injury

Flexible and stretchable implantable devices for peripheral neuromuscular electrophysiology

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