Comparative effects of drugs on four paw oedema models in the rat

Abstract

The development of novel anti-inflammatory drugs (AID) has been claimed to be dependent on the discovery of models of inflammation that differ from those currently used for drug screening, e.g. carrageenen paw oedema and u.v. erythema. We have thus evaluated the effect of a variety of drugs in a number of novel models of inflammation in the rat produced in the hind paw. We have utilized kaolin, zymosan, anti-rat IgG (anti-IgG) and the Reversed Passive Arthus (RPA) reaction to produce these oedema models. We found that the non-steroidal AID's, e.g. aspirin, flufenamic acid, indomethacin, naproxen, and phenylbutazone, were active in all four tests. Of the nine novel AID examined, levamisole and tetramisole demonstrated considerable activity in all four tests and dapsone was especially active in the anti-IgG and RPA tests. In contrast, the anti-rheumatic d-penicillamine was inactive in all four models. Each of the ten compounds tested which has been claimed to influence complement function, was active in the RPA but not in the kaolin model. These results are discussed in the context of the aetiology of each oedema and the suspected mode of action of the various drugs.

Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

“…reduced the inflammatory reaction in two in vivo models of acute inflammation, carrageenan-induced mouse paw oedema and rat pleurisy, being about as effective as 5 mg·kg -1 indomethacin. During carrageenan-induced oedema formation, PGE2 levels are significantly elevated (Harada et al, 1982;Guay et al, 2004), and COX inhibitors prevent the inflammatory response (Gemmell et al, 1979). Results from studies using carrageenan-induced paw oedema and i.p.…”

Kinins and peritoneal exudates induced by carrageenin and zymosan in rats

“…Several attempts have been made to develop other inflammatory models. Among these attempts, cobra venom factor or zymosan were used to induce complementdependent inflammatory reactions in the skin (Konno & Tsurufuji, 1983), paws (Gemmel et al, 1979;Leyck et al, 1983;, and the pleural (Martins et al, 1989) or abdominal cavities of rats (Wood et al, 1988;Griffiths & Wood, 1989). To compare both models, we examined the peritonitis induced by zymosan and by carrageenin.…”

Inhibitory Effects of a Novel Synthetic Protease Inhibitor, FUT-175, on the Paw Edema in Rats and Zymosan-induced Complement Activation in Vitro

“…The complement system has been speculated by Gemmell et al (9) to play important roles in zymosan-induced paw edema (9). We reported in the preceding paper (6) that FUT-175 has potent in vitro and in vivo inhibitory activity on comple ment, as well as on other serine proteases such as trypsin, kallikrein, thrombin and plasmin.…”