Comparative Effects of Dihydroergotamine and Hydergin® On the Blood Flow, Capillary Filtration Rate and the Capacitance Vessels in the Human Calf Studied By Plethysmography

Ulrich, J; Jessen, Barbara; Siggaard-Andersen, J

doi:10.1177/000331977302401101

Cited by 11 publications

(4 citation statements)

References 6 publications

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“…In contrast to other representatives of the ergot compounds like crgotamine or ergonovine, dihydroergotoxine induces no significant vasoconstrictive effects on arterioles or venous capacitance vessels in normotensive man (4). In accordance with these reports, harmful effects on the coronary circulation under clinical or experimental conditions have been observed only with ergonovine and ergotamine (16--18), whereas no such evidence has been convincingly documented for the hydrogenated alkaloids, dihydroergotamine (DHE) and dihydroergotoxine.…”

Section: Discussionmentioning

confidence: 90%

“…According to its pharmacological properties, dihydroergotoxine, consisting in equal parts of the hydrogenated alkaloids dihydroergocornine, dihydroergocristine, and dihydroergocryptine, seems to possess these qualities: it acts both as vasodilator in arterial resistance vessels due to its potent ct-sympatholytic activity, and as myocardial oxygen-saving agent due to its centrally-mediated decrease in heart rate (3)(4)(5). It is used clinically in circulatory disorders such as cerebrovascular insufficiency, intermittent claudication, or hypertension (6)(7)(8)(9), but no data exist on its efficacy under conditions of coronary insufficiency.…”

Section: Introductionmentioning

confidence: 99%

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Dihydroergotoxine, an ergot alkaloid without marked hypotensive effect, improves blood flow and metabolism in the underperfused canine myocardium

Seitelberger

Raberger

1985

Basic Res Cardiol

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Regional myocardial blood flow was assessed in 6 anaesthetized dogs using radiolabelled microspheres. Lactate, H+, and O2 content were measured in arterial and local venous blood, obtained from the area supplied by the circumflex branch of the left coronary artery (LCX). Constriction of LCX by 67% led to considerable hemodynamic changes indicative of depressed global myocardial function. A significant release of lactate from the underperfused part of the left ventricle was recorded. Infusion of 0.7 micrograms/kg dihydroergotoxine over a period of 5 min induced a decrease in heart rate, left ventricular dp/dt max, and cardiac output, a sustained increase in total peripheral and femoral resistance and a transient increase in mean arterial blood pressure. Dihydroergotoxine markedly reduced lactate release and even, in some cases, induced lactate uptake and led to a significant increase in the endocardial blood flow both in the underperfused and normally perfused left ventricle. It is concluded that dihydroergotoxine, due to its ability to reduce myocardial oxygen demand and owing to its alpha-sympatholytic activity, which is not accompanied by any marked decrease in arterial blood pressure, causes improvement in blood flow in the underperfused myocardium and a marked amelioration of the impaired metabolic processes.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Dihydroergotoxine, an ergot alkaloid without marked hypotensive effect, improves blood flow and metabolism in the underperfused canine myocardium

Seitelberger

Raberger

1985

Basic Res Cardiol

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“…At present, only a few substances are known that cause selective venoconstriction. Dihydrogenated ergot pep tide alkaloids belong to the drugs with prefer entially venoconstrictor effects which reside mainly in an activation of «-adrenoceptors [1,7,8,16,20], In studies using animal vas cular preparations ergot peptide alkaloids proved to be partial agonists of a-adrenoceptors [14. 16].…”

Section: Introductionmentioning

confidence: 99%

Dual Effect of Dihydroergotamine and Dihydroergotoxin in Isolated Human Femoral Veins and Arteries

Glusa¹,

Markwardt²

1982

Pharmacology

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In human femoral vein strips, dihydroergotamine and dihydroergotoxin caused a slowly proceeding, long-lasting increase in tone. Dihydroergotamine had markedly higher affinity than noradrenaline, it possessed nearly the same intrinsic activity as noradrenaline. Dihydroergotoxin was less effective than dihydroergotamine. In isolated femoral artery strips, dihydroergotamine showed lower affinity and lower intrinsic activity in terms of noradrenaline. Dihydroergotoxin had negligible vasoconstrictor effects in arteries. In veins, dihydroergotoxin had a stronger α-adrenolytic effect than in arteries. In isolated arteries, dihydroergotoxin was equieffective to dihydroergotamine whose α-adrenoceptor blocking effect did not significantly differ in veins and arteries. Our results show that dihydroergotamine at very low concentrations exerted predominantly venoconstrictor effects and, therefore, it is more suited to increase the venous tone than dihydroergotoxin which at low concentrations showed α-adrenoceptor blocking activity.

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“…"Ετσι επί τού καρδιαγγειακού συστήματος εξασκεί αγγειοδια σταλτική επίδραση στά συνεσπασμένα άπό τίς κατεχολαμΐνες αγγεία. (17,36,45,87,214,221,250,288,289,325,333,354,381,396) καί αρνητική χρονότροπο (1, 21, 279,347) καί ίνότροπο(91,2Ι7, 287, 417) δράση στή καρδιά, πού οφείλεται κυρίως στην αναστολή τώναάδρενεργικών υποδοχέων (351).…”

Section: διυδρογονωμενα παραγωγα της ερυσιβωδους ολυρας-διυδροεργοτοξινηunclassified

Μεθανοσουλφονικη Διυδροεργοτοξινη Και Συσσωρευση Αιμοπεταλιων Ανθρωπου

Παππασ¹

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Γεννήθηκα στην Παλαιομάνινα -Μεσολογγίου τό 1948 οπού τελείωσα τό δημοτικό σχολείο. Τίς Γυμνασιακές μου Σπουδές περάτωσα στό Δ' Γυμνάσιο Πειραιώς. Μετά επιτυχείς εξετάσεις εισήλθα τό 1967 στην 'Ιατρική Σχολή του Πανεπιστημίου 'Αθηνών καί τόν Φεβρουάριο τοΰ 1975 πήρα τό πτυχίο τής 'Ιατρικής μέ «Λίαν Καλώς». 'Από 1975 -1977 υπηρέτησα στό Στρατό Ξηράς ώς οπλίτης ιατρός. 'Από Φεβρουάριο 1976 -Φεβρουάριο 1977 υπηρέτησα στό 'Αγροτικό ιατρείο Λυκουρίας -Καλαβρύτων καί άπό τό Σεπτέμβριο 1977 -Σεπτέμβριο 1978 υπηρέτησα στό 'Αγροτικό ιατρείο Έμπεσοϋ -Βάλτου Αίτωλ/νίας. Τήν εκπαίδευση γιά τήν ειδικότητα τής Παθολογίας έλαβα στή Α Παθολογική Κλινική του Γενικού Κρατικού Νοσοκομείου Νι καίας Πειραιώς (Διευθυντής : Γεώργιος Γιαννακούρης) άπό τόν 'Οκτώβριο 1978 εως τόν 'Ιούνιο τοΰ 1981. Τόν τίτλο ειδικότητας Παθολογίας έλαβα τόν Νοέμβριο τοΰ 1981. ' Η παρούσα διατριβή έγινε υπό τήν εποπτεία τοΰ καθηγητού τής Πειραματικής Φαρμοκολογίας τής 'Ιατρικής Σχολής τοΰ Πάνε πιστημίου Κου. Δ. Δ. Βαρώνου.

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Comparative Effects of Dihydroergotamine and Hydergin® On the Blood Flow, Capillary Filtration Rate and the Capacitance Vessels in the Human Calf Studied By Plethysmography

Cited by 11 publications

References 6 publications

Dihydroergotoxine, an ergot alkaloid without marked hypotensive effect, improves blood flow and metabolism in the underperfused canine myocardium

Dihydroergotoxine, an ergot alkaloid without marked hypotensive effect, improves blood flow and metabolism in the underperfused canine myocardium

Dual Effect of Dihydroergotamine and Dihydroergotoxin in Isolated Human Femoral Veins and Arteries

Μεθανοσουλφονικη Διυδροεργοτοξινη Και Συσσωρευση Αιμοπεταλιων Ανθρωπου

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