Comparative effects of different enzymatic hydrolysates of konjac glucomannan on gut flora and constipation in rats

Chang, Xiaoyan; Liu, Yuan Yuan; Hu, Mengmeng; Liu, Youqian; Jiang, Cuihua; Wang, Qi; Jin, Qiaomei; Zhang, Dongjian; Yin, Zhiqi; Zhang, Jian

doi:10.1039/d2fo01144a

Cited by 5 publications

(7 citation statements)

References 36 publications

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“…52 Previous studies have shown that prebiotics can reduce constipation by regulating the microbial composition of the intestinal tract. 53,54 Both polyphenols and polysaccharides extracted from FBT have been proven to regulate intestinal flora and maintain host health. 25,26 FTE is extracted from FBT infusion, which has been proven to promote the colonization of beneficial bacteria such as Roseburia and Lactobacillus.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Gut microbiota are closely related to host health and influenced by nutritional intake and lifestyle . Previous studies have shown that prebiotics can reduce constipation by regulating the microbial composition of the intestinal tract. , Both polyphenols and polysaccharides extracted from FBT have been proven to regulate intestinal flora and maintain host health. , FTE is extracted from FBT infusion, which has been proven to promote the colonization of beneficial bacteria such as Roseburia and Lactobacillus . Here, the 16S rRNA gene amplicon sequencing technology was used to analyze gut microbial changes.…”

Section: Discussionmentioning

confidence: 99%

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Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

Zhang

et al. 2023

J. Agric. Food Chem.

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This study aimed to investigate the amendatory effects of Fu brick tea aqueous extract (FTE) on constipation and its underlying molecular mechanism. The administration of FTE by oral gavage (100 and 400 mg/kg•bw) for 5 weeks significantly increased fecal water content, improved difficult defecation, and enhanced intestinal propulsion in loperamide (LOP)-induced constipated mice. FTE also reduced colonic inflammatory factors, maintained the intestinal tight junction structure, and inhibited colonic Aquaporins (AQPs) expression, thus normalizing the intestinal barrier and colonic water transport system of constipated mice. 16S rRNA gene sequence analysis results indicated that two doses of FTE increased the Firmicutes/Bacteroidota (F/B) ratio at the phylum level and increased the relative abundance of Lactobacillus from 5.6 ± 1.3 to 21.5 ± 3.4% and 28.5 ± 4.3% at the genus level, subsequently resulting in a significant elevation of colonic contents short-chain fatty acids levels. The metabolomic analysis demonstrated that FTE improved levels of 25 metabolites associated with constipation. These findings suggest that Fu brick tea has the potential to alleviate constipation by regulating gut microbiota and its metabolites, thereby improving the intestinal barrier and AQPs-mediated water transport system in mice.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

Zhang

et al. 2023

J. Agric. Food Chem.

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“…Glucomannan and its hydrolysate oligosaccharides can selectively regulate the number and distribution of beneficial intestinal microflora (lactic acid bacteria, bifidobacteria, cecal anaerobes, etc. ), reduce the incidence of colon cancer, and have excellent prebiotic effects [ 34 , 35 , 36 , 37 ]. In the near future, related products with glucomannan as the main raw material, such as some medical functional foods, will gradually enter the market and become known to the public.…”

Section: Discussionmentioning

confidence: 99%

Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis

Zhang

Tao

et al. 2023

Nutrients

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The hypoglycemic and lipid-lowering effects of glucomannan are widely known, and it is a potential effective treatment for type II diabetes. In this study, we evaluated the effects of glucomannan supplementation on blood-lipid-related indicators, blood-glucose-related indicators, blood pressure (BP), and body weight (BW) in patients suffering from type II diabetes. We searched databases including PubMed, Cochrane, the comprehensive biomedical research database (Embase), Web of Science, and China National Knowledge Infrastructure (CNKI) for literature on glucomannan and type II diabetes. Six randomized controlled trials (RCTs) were eligible (n = 440 participants) to be included in our analysis. Glucomannan not only reduced the total cholesterol (TC) (MD −0.38 [95% CI: −0.61, −0.15], p = 0.001) and low-density lipoprotein (LDL) levels (MD −0.35 [95% CI: −0.52, −0.17], p < 0.0001) compared with the control group, but also reduced the fasting blood glucose (FBG) (MD −1.08 [95% CI: −1.65, −0.50], p = 0.0002), 2 h postprandial blood glucose (P2hBG) (MD −1.92 [95% CI: −3.19, −0.65], p = 0.003), fasting insulin (FINS) (MD −1.59 [95% CI: −2.69, −0.50], p = 0.004), and serum fructosamine (SFRA) levels (SMD −1.19 [95% CI: −1.74, −0.64], p < 0.0001). Our analysis indicates that glucomannan is an effective nutritional intervention for type II diabetes.

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“…Previous studies showed that konjac glucomannan could alleviate constipation by increasing SCFA levels, which were crucial for maintaining the microecological balance of the intestine. 69 SCFAs could lower the gut pH, which may inhibit the growth of harmful bacteria and boost salt and hydration absorption in the colon. 70 Furthermore, studies reported that SCFAs could promote the growth of colon cells.…”

Section: Food and Function Papermentioning

confidence: 99%

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Song,

Guo,

Sun

et al. 2023

Food Funct.

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Comparative effects of different enzymatic hydrolysates of konjac glucomannan on gut flora and constipation in rats

Abstract: This study aimed to compare the effects of different hydrolysates (named GKOS and MKOS) on constipated rats, which were degraded to obtain from konjac glucomannan by β-glucanase and β-mannanase, respectively....

Cited by 5 publications

References 36 publications

Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

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