Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt

Shah, Manasvi S.; Kim, Eun-Joo; Davidson, Laurie A.; Knight, Jason; Zoh, Roger S.; Goldsby, Jennifer S.; Callaway, Evelyn S.; Zhou, Beyian; Ivanov, Ivan; Chapkin, Robert S.

doi:10.1016/j.bbadis.2015.10.012

Cited by 19 publications

(16 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 1 summarizes specific miRNAs modulated by a combination fish oil and pectin diet with respect to their validated mRNA target genes. Surprisingly, miR-21 was decreased by the combination diet compared to the control diet (189, 190). This is noteworthy because, as previously noted, miR-21 is a well-known oncogenic miRNA, and its validated targets, PDCD4 and PTEN, are known tumor suppressor genes (9, 135, 229).…”

Section: Effects Of N-3 Pufa Fiber and Curcumin On Noncoding Micrornasmentioning

confidence: 85%

“…For example, repression of the translation of select miRNAs in stem cells and differentiated daughter cells has been shown to be a means of regulating stem cell renewal and differentiation (56, 66, 94). Although evidence supports the beneficial effects of certain dietary components on suppression of colon cancer cells (46, 190), a comprehensive, comparative analysis of the effects of these dietary agents on colonic stem cells has not yet been conducted (189). …”

Section: Effects Of N-3 Pufa Fiber and Curcumin On Noncoding Micrornasmentioning

confidence: 99%

See 1 more Smart Citation

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

et al. 2016

Self Cite

View full text Add to dashboard Cite

The International Agency for Research on Cancer recently released an assessment classifying red and processed meat as “carcinogenic to humans” on the basis of the positive association between increased consumption and risk for colorectal cancer. Diet, however, can also decrease the risk for colorectal cancer and be used as a chemopreventive strategy. Bioactive dietary molecules, such as n-3 polyunsaturated fatty acids, curcumin, and fermentable fiber, have been proposed to exert chemoprotective effects, and their molecular mechanisms have been the focus of research in the dietary/chemoprevention field. Using these bioactives as examples, this review surveys the proposed mechanisms by which they exert their effects, from the nucleus to the cellular membrane. In addition, we discuss emerging technologies involving the culturing of colonic organoids to study the physiological effects of dietary bioactives. Finally, we address future challenges to the field regarding the identification of additional molecular mechanisms and other bioactive dietary molecules that can be utilized in our fight to reduce the incidence of colorectal cancer.

show abstract

Section: Effects Of N-3 Pufa Fiber and Curcumin On Noncoding Micrornasmentioning

confidence: 85%

Section: Effects Of N-3 Pufa Fiber and Curcumin On Noncoding Micrornasmentioning

confidence: 99%

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, combination of dietary fish oil and fermentable fiber pectin led to up-regulation of several miR, including miR-19b, miR-26b, and miR-203, whose validated targets (PDE4B, PTK2B, TCF4, IGF1R, and BACE1) promote tumorigenesis, as compared to control corn oil diet. Surprisingly, miR-21 was increased by the combination diet as compared to the control diet (Shah et al, 2011, 2016). …”

Section: Protective Effectsmentioning

confidence: 86%

“…This led to enhanced expression of CDKN1C (p57 KIP2 ; Hu et al, 2015), one of the cyclin-dependent kinase inhibitors found dysregulated in cancer (Kavanagh and Joseph, 2011). As mentioned above, SCFA and fish oil ω3 PUFA worked coordinately in vivo to protect against colon tumorigenesis by modulating miR (Davidson et al, 2009; Shah et al, 2011, 2016). Collectively, these findings uncovered a novel mechanism whereby butyrate suppresses onco-miR biogenesis, promotes apoptosis and diminishes CRC cell proliferation.…”

Section: Protective Effectsmentioning

confidence: 92%

Linking Diet to Colorectal Cancer: The Emerging Role of MicroRNA in the Communication between Plant and Animal Kingdoms

et al. 2017

View full text Add to dashboard Cite

Environmental and lifestyle factors, including diet and nutritional habits have been strongly linked to colorectal cancer (CRC). Of note, unhealthy dietary habits leading to adiposity represent a main risk factor for CRC and are associated with a chronic low-grade inflammatory status. Inflammation is a hallmark of almost every type of cancer and can be modulated by several food compounds exhibiting either protective or promoting effects. However, in spite of an extensive research, the underlying mechanisms by which dietary patterns or bioactive food components may influence tumor onset and outcome have not been fully clarified yet. Growing evidence indicates that diet, combining beneficial substances and potentially harmful ingredients, has an impact on the expression of key regulators of gene expression such as the non-coding RNA (ncRNA). Since the expression of these molecules is deranged in chronic inflammation and cancer, modulating their expression may strongly influence the cancer phenotype and outcomes. In addition, the recently acquired knowledge on the existence of intricate inter-kingdom communication networks, is opening new avenues for a deeper understanding of the intimate relationships linking diet to CRC. In this novel scenario, diet-modulated ncRNA may represent key actors in the interaction between plant and animal kingdoms, capable of influencing disease onset and outcome. In this review, we will summarize the studies demonstrating a link between bioactive food components, including food-derived, microbiota-processed, secondary metabolites, and host ncRNA. We will focus on microRNA, highlighting how this plant/animal inter-kingdom cross-talk may have an impact on CRC establishment and progression.

show abstract

“…It has been shown that miRNA are critical for the appropriate regulation of fundamental cellular pathways and as such have been implicated in a range of processes that if incorrectly regulated can lead to diseases such as cancer (2,5,7) . Furthermore, dietary factors are thought to influence miRNA levels and potentially activate abnormal cellular pathways in cancer development (26)(27)(28)(29)(30)(31) , and Se status has been shown to affect miRNA levels in the CaCo-2 cell line (32) . However, the effect of dysregulated miRNA expression, due to a low-Se environment, on key pathways in cancer development and progression is unclear.…”

mentioning

confidence: 99%

Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line

et al. 2017

View full text Add to dashboard Cite

Se is an essential micronutrient for human health, and fluctuations in Se levels and the potential cellular dysfunction associated with it may increase the risk for disease. Although Se has been shown to influence several biological pathways important in health, little is known about the effect of Se on the expression of microRNA (miRNA) molecules regulating these pathways. To explore the potential role of Se-sensitive miRNA in regulating pathways linked with colon cancer, we profiled the expression of 800 miRNA in the CaCo-2 human adenocarcinoma cell line in response to a low-Se (72 h at <40 nM) environment using nCounter direct quantification. These data were then examined using a range of in silico databases to identify experimentally validated miRNA-mRNA interactions and the biological pathways involved. We identified ten Se-sensitive miRNA (hsa-miR-93-5p, hsa-miR-106a-5p, hsa-miR-205-5p, hsa-miR-200c-3p, hsa-miR-99b-5p, hsa-miR-302d-3p, hsa-miR-373-3p, hsa-miR-483-3p, hsa-miR-512-5p and hsa-miR-4454), which regulate 3588 mRNA in key pathways such as the cell cycle, the cellular response to stress, and the canonical Wnt/β-catenin, p53 and ERK/MAPK signalling pathways. Our data show that the effects of low Se on biological pathways may, in part, be due to these ten Se-sensitive miRNA. Dysregulation of the cell cycle and of the stress response pathways due to low Se may influence key genes involved in carcinogenesis.

show abstract

Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt

Cited by 19 publications

References 99 publications

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

Linking Diet to Colorectal Cancer: The Emerging Role of MicroRNA in the Communication between Plant and Animal Kingdoms

Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line

Contact Info

Product

Resources

About