Comparative effects of chemosterilants on spermatogenic stages in the house fly I. Induction of dominant lethal mutations in mature sperm and gonial cell death

Lachance, Leo E.; Degrugillier, Maurice E.; Leverich, Ann P.

doi:10.1016/0027-5107(69)90050-5

Cited by 13 publications

(2 citation statements)

References 27 publications

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“…Simple diesters of methanesulphonic acid produce characteristic antifertility effects in rodents (Jackson, , 1966 and show chemosterilant activity in insects (Crystal, 1968;LaChance, Degrugillier & Leverich, 1969). In the latter species, the effects involve sterilization of spermatozoa (induction of 'dominant lethal mutations') with surprisingly little effect on the proliferative stages of the spermatogenic process.…”

Section: Introductionmentioning

confidence: 98%

Comparative Effects of Methylene, Ethylene and Propylene Dimethanesulphonates on the Male Rat Reproductive System

Cooper¹,

Jackson²

1970

Reproduction

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Histological changes in the rat testis were correlated with the antifertility effects of injections of three diol diesters of methanesulphonic acid. The compounds are consecutive members of a homologous series each differing by -CH2-from its neighbours. The diester of ethylene glycol (EDS) caused antispermatogenic effects resembling those following hypophysectomy and was associated with involution of prostate and epididymis; spermatocoele formation occurred in the latter organ. Methylene dimethanesulphonate and 1,3-propylene dimethanesulphonate induced changes consistent with spermatogonial damage resembling those produced by Myleran (busulphan).

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Section: Introductionmentioning

confidence: 98%

Comparative Effects of Methylene, Ethylene and Propylene Dimethanesulphonates on the Male Rat Reproductive System

Cooper¹,

Jackson²

1970

Reproduction

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“…It is probable that an apholate-like action of hempa may be due to its prior conversion to an alkylating metabolite (Borkove~,!968). Chemosterilants are known to produce dominant lethal mutations in the germ cells of the treated organisms and in the process a large number of gonial cells may be killed (LaChance et al, 1969). This may explain the inhibition of DNA synthesis in gonads of A. aegypti as observed.…”

Section: Resultsmentioning

confidence: 98%

Incorporation of Thymidine Into Dna of the Gonads in the Normal and Chemosterilized Yellow‐fever Mosquito

Madhukar

Pillai

Agarwal

et al. 1970

Entomologia Exp Applicata

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Effect of the chemosterilants, apholate and hempa, on the incorporation of tritiated thymidine in DNA of the gonads of Aedes aegypti was studied. Larval treatment with sterilizing doses of the chemosterilants caused inhibition of DNA synthesis in the gonads. The inhibition was found to be more in testes than in ovaries. The significance of these findings in relation to the mode of action of these chemosterilants is discussed. Zusammenfassung EINBAU VON THYMIDIN IN DIE DNS DER GONADEN VON NORMALEN UND CHEMOSTERILISIERTEN GELBFIEBERMÜCKEN Die Wirkung der Chemosterilantien Apholate und Hempa auf den Hinbau von tritiummarkiertem Thymidin in die DNS der Gonaden von Gelbfiebermücken wurde untersucht. Behandlung der Larven mit sterilisierenden Dosen der Chemosterilantien verursachte Hemmung der DNS‐Synthese in den Gonaden. Die Hemmung erwies sich in den Hoden als stärker als in den Ovarien. Die Bedeutung dieser Befunde in Beziehung zur Wirkungsweise dieser Chemosterilantien wird diskutiert.

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N , N ′‐Tetramethylenebis(1‐Aziridine‐Carboxamide) 6611‐01‐4

2004

Sax's Dangerous Properties of Industrial Materials

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Comparative effects of chemosterilants on spermatogenic stages in the house fly I. Induction of dominant lethal mutations in mature sperm and gonial cell death

Cited by 13 publications

References 27 publications

Comparative Effects of Methylene, Ethylene and Propylene Dimethanesulphonates on the Male Rat Reproductive System

Comparative Effects of Methylene, Ethylene and Propylene Dimethanesulphonates on the Male Rat Reproductive System

Incorporation of Thymidine Into Dna of the Gonads in the Normal and Chemosterilized Yellow‐fever Mosquito

N , N ′‐Tetramethylenebis(1‐Aziridine‐Carboxamide) 6611‐01‐4

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