Comparative effects of a tocotrienol‐rich fraction and tocopherol in aspirin‐induced gastric lesions in rats

Abstract

This study examined the effects of a tocotrienol-rich fraction (TRF) obtained from palm oil on the healing of aspirin-induced gastric mucosal lesions. Thirty-six male Sprague-Dawley rats (200-250 g) were randomly divided into three groups. Group I was fed a vitamin E-deficient diet (control), Group II was fed a vitamin E-deficient diet supplemented with tocopherol (300 mg/kg food) and Group III was fed a vitamin E-deficient diet supplemented with TRF (300 mg/kg food). After eight weeks, the control and treated groups received a single intragastric dose of 400 mg/kg body weight aspirin. The rats were killed 24 h after exposure to aspirin. Assessment of gastric lesions showed a lower gastric lesion index in the TRF (P = 0.0005) and tocopherol groups (P = 0.0008) compared to the control. The gastric malondialdehyde (MDA) content was also lower in the TRF (P = 0.025) and tocopherol groups (P = 0.025) compared to control. There were, however, no significant differences in the gastric lesion index and gastric MDA content between the TRF and tocopherol-fed groups. There were no significant differences in the adherent gastric mucous concentration and gastric acid concentration among all groups. We conclude that the TRF and tocopherol are equally effective in preventing aspirin-induced gastric lesions. The most probable mechanism is through their ability to limit lipid peroxidation, which is involved in aspirin-induced gastric lesions.

The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats

“…Furthermore, supplementation of PVE and α-TF at 60 mg/kg for 28 days prior to exposure to stress reduced gastric mucosal injury. This finding is similar to other studies [35, 46, 47]. Nur Azlina et al .…”

Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats

“…Studies have shown that free-radical scavengers, such as vitamin E, vitamin A, and plant extracts from Falcaria vulgaris, Shankha bhasma, Kielmeyera coriacea, Ginkgo biloba, and Nigella sativa L, provide protective effects against experimentally induced gastric lesions [25][26][27][28][29]. Administration of fish oil, which is known to contain half the quantity of omega-3 compared with flaxseed oil, was found to significantly protect against ethanol-induced gastric ulcers in rats at doses of 5 and 10 ml/kg body weight [24].…”

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases

“…Both tocopherols and tocotrienols had gastroprotective effects against damage by free radicals generated in stress conditions, but only tocotrienols had the ability to block stress-induced changes in gastric acidity and gastrin level. Another group showed that tocotrienols can prevent aspirin-induced gastric lesions through their ability to limit lipid peroxidation [142]. …”