Comparative Effects of 30 Antipsychotics on Risk of Catatonia

Costa, Julien Da; Véry, Etienne; Rousseau, Vanessa; Virolle, Jordan; Redon, Maximilien; Taïb, Simon; Revet, Alexis; Montastruc, François

doi:10.4088/jcp.21m14238

Cited by 9 publications

(4 citation statements)

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“…FGAs carry a higher risk than SGAs of being associated with antipsychotic-induced catatonia. 14 , 32 FGAs also have a known risk of precipitating malignant catatonia or NMS when given in the presence of catatonia. 15 While there are numerous reported cases of NMS or worsened catatonia caused by SGAs, there are also numerous reports of catatonia being definitively treated with SGAs both with and without benzodiazepines.…”

Section: Discussionmentioning

confidence: 99%

Catatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series

Dragonetti,

Posada,

Key

et al. 2024

SAGE Open Medical Case Reports

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Due to a lack of controlled, prospective trials examining the pathophysiology and treatment of catatonia, current guidelines vary regarding how and when to best use antipsychotics in the presence of catatonia and what factors to consider in a thorough risk–benefit analysis. The literature is especially limited in describing the risks and benefits of using long-acting injectable antipsychotics in the presence of catatonia. We describe four cases where patients with preexisting catatonia received long-acting injectable first generation antipsychotics and experienced severe adverse effects (three experienced worsening of catatonia and one experienced neuroleptic malignant syndrome). The evidence base for managing comorbid catatonia and psychosis remains underdeveloped and inconsistent, but there are numerous known risk factors for adverse antipsychotic reactions, which we describe in relation to these cases. Finally, we present best practices to consider when managing comorbid psychosis and catatonia, especially when considering the use of long-acting injectable antipsychotics.

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Section: Discussionmentioning

confidence: 99%

Catatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series

Dragonetti,

Posada,

Key

et al. 2024

SAGE Open Medical Case Reports

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“…Analysis of the World Health Organization Pharmacovigilance Database indicates that first-generation antipsychotics are associated with a twofold increase in risk of catatonia compared to second-generation antipsychotics. 48 Haloperidol is four times more likely to be associated with catatonia. Prochlorperazine, clozapine, and asenapine are associated with the lowest risks.…”

Section: Questions To the Consultantsmentioning

confidence: 99%

“…There is concern that their higher D2 dopamine receptor antagonism is more likely to worsen catatonia than second-generation antipsychotics, which have less D2 antagonism. Analysis of the World Health Organization Pharmacovigilance Database indicates that first-generation antipsychotics are associated with a twofold increase in risk of catatonia compared to second-generation antipsychotics 48 . Haloperidol is four times more likely to be associated with catatonia.…”

Section: Questions To the Consultantsmentioning

confidence: 99%

Use of First-Generation Antipsychotics in an Adolescent Male with Catatonic Schizophrenia

Patterson,

Lim,

Fuchs

et al. 2023

Harv Rev Psychiatry

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“…The most widely studied class of models are models of drug-induced catatonia based on behavioral effects of antipsychotic drugs such as haloperidol [104][105][106][107]. These models have emerged because of the known risk of catatonia in patients taking first-generation antipsychotics [108]. The use of dopamine (D2) and α-adrenergic receptor antagonists such as haloperidol limits the investigation into the etiopathogenesis of catatonia to monoamines.…”

Section: Other Animal Models Of Catatoniamentioning

confidence: 99%

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Ryazanova,

Plekanchuk,

Prokudina

et al. 2023

Biomedicines

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Research into genetic and physiological mechanisms of widespread disorders such as arterial hypertension as well as neuropsychiatric and other human diseases is urgently needed in academic and practical medicine and in the field of biology. Nevertheless, such studies have many limitations and pose difficulties that can be overcome by using animal models. To date, for the purposes of creating animal models of human pathologies, several approaches have been used: pharmacological/chemical intervention; surgical procedures; genetic technologies for creating transgenic animals, knockouts, or knockdowns; and breeding. Although some of these approaches are good for certain research aims, they have many drawbacks, the greatest being a strong perturbation (in a biological system) that, along with the expected effect, exerts side effects in the study. Therefore, for investigating the pathogenesis of a disease, models obtained using genetic selection for a target trait are of high value as this approach allows for the creation of a model with a “natural” manifestation of the pathology. In this review, three rat models are described: ISIAH rats (arterial hypertension), GC rats (catatonia), and PM rats (audiogenic epilepsy), which are developed by breeding in the Laboratory of Evolutionary Genetics at the Institute of Cytology and Genetics (the Siberian Branch of the Russian Academy of Sciences).

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Comparative Effects of 30 Antipsychotics on Risk of Catatonia

Cited by 9 publications

References 0 publications

Catatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series

Catatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series

Use of First-Generation Antipsychotics in an Adolescent Male with Catatonic Schizophrenia

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

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