Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis

Abstract

Overholser CD, Meiiler TF, DePaola LG, Minah GE and Niehaus C: Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol 1990; 17: 575-579. Abstract. A 6-month double-blind, controlled clinical study was completed with 124 healthy adult subjects to determine the efficacy of 2 mouthrinses, Listerine (LA) and Peridex (PX), used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis. Following screening examinations for entry levels of existing gingivitis and plaque, baseline gingival and plaque area indices, extrinsic tooth stain, supragingival calculus, bleeding and soft tissue condition were recorded. All subjects then received a complete dental porphylaxis to remove plaque, calculus and extrinsic stain. Subjects were randomly assigned to 1 of 3 groups and performed supervised rinses twice daily for 30 s in addition to their normal oral hygiene, for 6 months. All indices were again evaluated at 3 and 6 months. After 6 months, LA and PX significantly (p< 0.001) inhibited development of plaque by 36.1% and 50.3%, respectively, and the development of gingivitis by 35.9% and 30.5%, respectively, compared to a hydroalcohol control. PX was more effective in inhibiting plaque and both mouthrinses appeared to be equally effective in inhibiting gingivitis. LA patients did not develop significant levels of stain or supragingival calculus at 6 months, compared to basehne or control. PX patients developed significant levels of extrinsic stain and supragingival calculus compared to basehne and control. Though PX was more effective than LA in the control of plaque, this study indicates that both LA and PX were effective agents in a regimen for the control of plaque and gingivitis.

Comparative antiplaque and antigingivitis efficacy of three antiseptic mouthrinses: a two week randomized clinical trial

“…An essential oil-containing mouthrinse (EO) has demonstrated significant antiplaque and antigingivitis efficacy in short-term 7,8,9 and long-term clinical studies 6,10,11,12,13 designed within the guidelines required by the American Dental Association Council on Scientific Affairs for evaluating the clinical efficacy of chemotherapeutic mouthrinses.…”

Validation of the anti-bacteremic efficacy of an essential oil rinse in a Brazilian population: a cross-over study

“…This data confirmed that rinsing regularly with an EOcontaining mouthrinse twice a day can reduce the level of blood-borne bacteria caused by a standardized challenge such as that of chewing an apple. It seems reasonable to assume that maintaining good oral hygiene practices, including tooth brushing, flossing and using an effective antimicrobial mouthrinse agent regularly, contributes to preventing periodontal disease, [7][8][9][10][11][12] which, in turn, leads to a lower risk of developing bacteremia.…”

“…Essential-oil-containing mouthrinses (EOM) have shown anti-plaque and anti-gingivitis properties in short-7-9 and long-term clinical studies [10][11][12] designed according to the guidelines of the American Dental Association Council on Scientific Affairs. 13 Recently, Fine et al…”

Present and Future Non-Surgical Therapeutic Strategies for the Management of Periodontal Diseases

“…Overholser et al (Overholser, et al, 1990) Chlorhexidine 0.12% Hydrogen Peroxide 1% Placebo 32 subjects ceased oral hygiene procedures, but rinsed, twice a day, with the designated mouthrinse for 21 days.…”

“…Long-term reductions in plaque averaged between 45-61% and in gingivitis, 27-67% (Ciancio, 1989). Adverse effects reported may include staining of teeth, reversible desquamation, poor taste and alteration of taste and an increase in supragingival calculus (Flotra, et al, 1972, Overholser, et al, 1990). …”