Comparative effectiveness of [<sup>18</sup>F]‐fluorocholine PET‐CT and pelvic MRI with diffusion‐weighted imaging for staging in patients with high‐risk prostate cancer

Pinaquy, Jean-Baptiste; Clermont-Galleran, Henri De; Pasticier, G.; Rigou, G.; Alberti, N; Hindié, Elif; Mokrane, Yacoub; Fernandez, Philippe

doi:10.1002/pros.22921

Cited by 63 publications

(45 citation statements)

References 28 publications

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“…Certainly each modality has its advantages. MRI provides a sharper, higher spatial resolution image and therefore a higher accuracy for the assessment of the delineation between the tumour and surrounding anatomical structures [17]. PSMA PET/CT detects the same if gross invasion is present, as was the case in the example given by Giesel et al [16].…”

mentioning

confidence: 95%

Molecular imaging using PSMA PET/CT versus multiparametric MRI for initial staging of prostate cancer: comparing apples with oranges?

Mottaghy

Heinzel

Verburg

2016

Eur J Nucl Med Mol Imaging

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Molecular imaging of glutamate carboxypeptidase II, also called prostate-specific membrane antigen (PSMA) [1], has seen an unprecedentedly rapid adoption in prostate cancer (PCA) imaging in the last few years. Wherever local laws and regulations allow and a sufficiently equipped radiochemical laboratory is available, this tracer has now completely replaced radiolabelled choline PET/CT in the imaging of recurrent PCA. Indeed, even though the first results from larger retrospective series have only been published in the last 18 months [2][3][4][5] This molecular imaging approach certainly represents a major advance over previous PET/CT tracers. It has a much better signal-to-background ratio and its very strong uptake in target lesions allows lesions as small as 2.4 mm in short-axis diameter to be detected [6]. As these probes are still very new, we as nuclear medicine physicians are still on the ascending slope of a steep learning curve. For instance, it has become clear that while the very high sensitivity of this tracer has often been confirmed [2,7], it is not as specific as we would wish: a considerable degree of tracer uptake is seen both in other malignancies [8,9] and in normal anatomical structures such as the coeliac ganglia which can easily be mistaken for malignant lesions [10].Whereas the clinical value of PSMA PET/CT in the imaging of (suspected) recurrent PCA is largely uncontested, this is not the case in the setting of primary staging. In the determination of lymph node status, the results published so far have been rather mixed -although it is remarkable that a study in which a nuclear medicine physician was not involved had rather poorer results [11] than studies in which nuclear medicine physicians were involved [7]. The intraprostatic delineation of tumour manifestations has been the focus of several recent studies [12][13][14]. In one study only the volumes on MRI and PSMA PET were compared [12]. The most accurate approach seems to be the integration of information obtained from PSMA PET/MRI imaging and from histopathology [13]. In another study an assessment of a small patient collective comparing multisegmental analysis of the prostate on P E T / C T w i t h t h e s a m e s e g m e n t a l a n a l y s i s o n postprostatectomy histology showed a very high positive and negative predictive value for the presence of PCA for each segment [14]. The initial results also showed that the intensity of PSMA uptake on PET correlates positively with the Gleason score [15].For the assessment of the local tumour status, multiparameter MRI is already a well-established, highly accurate imaging modality. The study presented by Giesel et al. [16] in this issue of the European Journal of Nuclear Medicine and Molecular Imaging compared local staging using this wellestablished standard imaging modality and [68 Ga]PSMA-HBED-CC PET/CT in ten patients who underwent imaging with both modalities prior to curative radiation therapy. Using a multisegment model in which each segment was analysed for PCA involvement b...

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confidence: 95%

Molecular imaging using PSMA PET/CT versus multiparametric MRI for initial staging of prostate cancer: comparing apples with oranges?

Mottaghy

Heinzel

Verburg

2016

Eur J Nucl Med Mol Imaging

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“…Several studies have shown a limited sensitivity of 11 C-choline PET/CT for the detection of extracapsular extension (e.g., 22% and 27% reported by Martorana et al and Rinnab et al, respectively (16,25)). Those results were confirmed by Pinaquy et al, who recently reported a higher sensitivity of diffusion-weighted (DW) MRI than of 18 F-choline PET/CT (73% vs. 36%) for the detection of seminal vesicle invasion (26). In a recently published review, De Bari et al concluded that MRI is superior to 11 C-or 18 F-choline PET/CT in terms of sensitivity and specificity for the local assessment of PC (27).…”

Section: T Stagingmentioning

confidence: 79%

“…On a lymph node basis, sensitivity was 56.2% and specificity was 94.0%. 18 F-choline PET/CT failed to detect nodal metastases smaller than 5 mm (35) (26). On a region basis, they reported a higher sensitivity (56%) and a higher positive predictive value (98%) for 18 F-choline PET/CT than for DW MRI (17% and 97%, respectively).…”

Section: N Stagingmentioning

confidence: 97%

Evaluation of Prostate Cancer with ¹¹C- and ¹⁸F-Choline PET/CT: Diagnosis and Initial Staging

et al. 2016

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“…Общая чувствительность и специфич-ность составили 78 и 94 % для ПЭТ/КТ, и 33 и 91 % для МРТ соответственно [45]. При сравнении резуль-татов расширенной лимфодиссекции у 112 пациентов с РПЖ с данными ПЭТ/КТ с 18 F-холином чувстви-тельность, специфичность, положительная и отрица-тельная прогностическая ценность составили 33, 92, 76 и 65 % соответственно [46].…”

Section: рис 1 рецидив рпж в ложе удаленной пж: а б -на т2-ви и т1unclassified

Dual-stage 18F-fluorocholine PET/CT scanning for biochemical recurrences of prostate cancer

Dolgushin¹,

Оджарова²,

Михайлов³

et al. 2015

Onkourologiya

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Comparative effectiveness of [¹⁸F]‐fluorocholine PET‐CT and pelvic MRI with diffusion‐weighted imaging for staging in patients with high‐risk prostate cancer

Abstract: This study highlights the interest of (18) F-Choline in the staging of high risk prostate cancer in addition with DWI MRI, especially so in the evaluation of lymph node involvement due to its high sensitivity and excellent specificity.

Cited by 63 publications

References 28 publications

Molecular imaging using PSMA PET/CT versus multiparametric MRI for initial staging of prostate cancer: comparing apples with oranges?

Molecular imaging using PSMA PET/CT versus multiparametric MRI for initial staging of prostate cancer: comparing apples with oranges?

Evaluation of Prostate Cancer with ¹¹C- and ¹⁸F-Choline PET/CT: Diagnosis and Initial Staging

Dual-stage 18F-fluorocholine PET/CT scanning for biochemical recurrences of prostate cancer

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Comparative effectiveness of [18F]‐fluorocholine PET‐CT and pelvic MRI with diffusion‐weighted imaging for staging in patients with high‐risk prostate cancer

Abstract: This study highlights the interest of (18) F-Choline in the staging of high risk prostate cancer in addition with DWI MRI, especially so in the evaluation of lymph node involvement due to its high sensitivity and excellent specificity.

Cited by 63 publications

References 28 publications

Molecular imaging using PSMA PET/CT versus multiparametric MRI for initial staging of prostate cancer: comparing apples with oranges?

Molecular imaging using PSMA PET/CT versus multiparametric MRI for initial staging of prostate cancer: comparing apples with oranges?

Evaluation of Prostate Cancer with 11C- and 18F-Choline PET/CT: Diagnosis and Initial Staging

Dual-stage 18F-fluorocholine PET/CT scanning for biochemical recurrences of prostate cancer

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Comparative effectiveness of [¹⁸F]‐fluorocholine PET‐CT and pelvic MRI with diffusion‐weighted imaging for staging in patients with high‐risk prostate cancer

Evaluation of Prostate Cancer with ¹¹C- and ¹⁸F-Choline PET/CT: Diagnosis and Initial Staging