Comparative effectiveness of pharmacologic and nonpharmacologic interventions for orthodontic pain relief at peak pain intensity: A Bayesian network meta-analysis

Abstract

The results show that analgesics and lasers are effective in the management of orthodontic pain at its peak intensity. Further research is required to improve the quality of evidence, especially for analgesic interventions.

Comparing the effectiveness profile of pharmacological interventions used for orthodontic pain relief: an arm-based multilevel network meta-analysis of longitudinal data

“…First, multilevel analysis of hierarchical data structure does provide precise estimates even when number of interventions is large and few studies are available for each comparison (5,8,9). This gain in precision was more pronounced for Nodes which had at least two Subnodes.…”

“…Network meta-analysis (NMA) has extended this concept of CER by providing estimates for comparative effectiveness of all competing interventions even when no head-head comparisons are available (3,4). Recently, Sandhu et al (5) conducted a NMA to examine the effectiveness of various intentions used for orthodontic pain relief. However, authors restricted their NMA to synthesize evidence for comparative effectiveness of various competing interventions for a single time point.…”

Ibuprofen and Low-level Laser Therapy for Pain Control during Fixed Orthodontic Therapy: A Systematic Review of Randomized Controlled Trials and Meta-analysis

“…Previously, several reviews have analyzed the results of the clinical trials to find the most efficient method of fixed orthodontic treatment pain management. 13,16,[24][25][26][27] However, they mostly did not consider several variables which could influence the results and cause bias. The number of included studies in this review was fewer compared to previous reviews as the aim of this review was to combine the results 10 10 Ibuprofen 400 mg 3 Steen Law et al, 29 Bradley et al, 30 and Minor et al 31 who measured analgesic effect of ibuprofen following elastic separator insertion were included in previous meta-analyses, 16,24,26,27 while they were excluded from this review as the pain might vary with pain caused by archwire placement.…”

Uso de analgésicos antiinflamatorios no esteroidales en ortodoncia: Revisión bibliográfica

“…Corresponde a un fármaco de segunda generación, altamente selectivo para la enzima COX-2 con propiedades analgésicas y antiinflamatorias, que posee un efecto inhibitorio dosis-dependiente sobre dicha enzima y vida media de 22 horas (larga) y que ha sido desarrollado para tratamientos de osteoartritis, artritis reumatoide y dolor. Este fármaco al ser un inhibidor de COX-2 tiene la ventaja de disminuir la inflamación en los sitios afectados, convirtiéndolo en un medicamento efectivo y bien tolerado en tratamientos 9,24 .…”

“…El uso de analgésicos es la modalidad comúnmente utilizada para controlar el dolor asociado con el tra-tamiento de ortodoncia [8][9][10][11][12] . Los AINES bloquean la síntesis de prostaglandinas a partir del ácido araquidónico, mediante la inhibición de la enzima ciclooxigenasa, además, se ha identificado que las prostaglandinas tienen una acción directa en el aumento del número y tamaño de osteoclastos, y en la estimulación de su actividad reabsortiva 13,14 .…”