Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for Empyema

Ampofo, Krow; Pavia, Andrew T.; Byington, Carrie L.; Sheng, Xiaoming; Greene, Tom; Korgenski, E. Kent; Hersh, Adam L.

doi:10.1542/hpeds.2015-0100

Cited by 22 publications

(15 citation statements)

References 29 publications

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“…The findings are consistent with those of a previous retrospective study that showed that oral route is as effective as intravenous route for completing the course of antibiotic therapy in children treated for complicated pneumonia,4 and also corroborate those of another study (by same group of authors) that showed no difference in treatment failure rates between groups (intravenous vs oral therapy) for children treated for acute osteomyelitis 5. However, there are some limitations in this study.…”

Section: Commentarysupporting

confidence: 92%

Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children

Onakpoya

2017

Evid Based Med

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Section: Commentarysupporting

confidence: 92%

Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children

Onakpoya

2017

Evid Based Med

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“…Prolonged antimicrobial therapy is warranted, irrespective of additive treatment modalities such as video-assisted thoracoscopic surgery (VATS) or fibrinolysis. A retrospective study comparing outpatient IV versus oral treatment did not show differences in outcome, thus promoting oral treatment [74]. This was confirmed by another retrospective cohort study evaluating 2132 children with empyema.…”

Section: Pleural Empyemamentioning

confidence: 71%

Childhood community-acquired pneumonia: A review of etiology- and antimicrobial treatment studies

Tramper-Stranders

2018

Paediatric Respiratory Reviews

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Community acquired pneumonia (CAP) is a leading cause of childhood morbidity worldwide. Because of the rising antimicrobial resistance rates and adverse effects of childhood antibiotic use on the developing microbiome, rational prescribing of antibiotics for CAP is important. This review summarizes and critically reflects on the available evidence for the epidemiology, etiology and antimicrobial management of childhood CAP. Larger prospective studies on antimicrobial management derive mostly from low- or middle-income countries as they have the highest burden of CAP. Optimal antimicrobial management depends on the etiology, age, local vaccination policies and resistance patterns. As long as non-rapid surrogate markers are used to distinguish viral- from bacterial pneumonia, the management is probably suboptimal. For a young child with signs of non-severe pneumonia (with or without wheezing), watchful waiting is recommended because of probable viral etiology. For children with more severe CAP with fever, a five-day oral amoxicillin course would be the first choice therapy and dosage will depend on local resistance rates. There is no clear evidence yet for superiority of a macrolide-based regimen for all ages. For cases with CAP requiring hospitalization, several studies have shown that narrow-spectrum IV beta-lactam therapy is as effective as a broad-spectrum cephalosporin therapy. For most severe disease, broad-spectrum therapy with or without a macrolide is suggested. In case of empyema, rapid IV-to-oral switch seems to be equivalent to prolonged IV treatment.

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“…1 Only 1 single-center study has addressed the effectiveness of PICC compared with oral antibiotic therapy in children with complicated pneumonia. 11 Our objectives were to compare the effectiveness of postdischarge oral versus intravenous antibiotics delivered via a PICC for children with complicated pneumonia and to determine differences in treatmentrelated complications.…”

mentioning

confidence: 99%

Intravenous Versus Oral Antibiotics for Postdischarge Treatment of Complicated Pneumonia

Shah

Srivastava

et al. 2016

Pediatrics

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Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for Empyema

Abstract: The frequency of complications was similar with oral therapy and OPAT for children with PPE. Oral antibiotics may be considered safe and effective for children with PPE who will be discharged to complete therapy in the outpatient setting.

Cited by 22 publications

References 29 publications

Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children

Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children

Childhood community-acquired pneumonia: A review of etiology- and antimicrobial treatment studies

Intravenous Versus Oral Antibiotics for Postdischarge Treatment of Complicated Pneumonia

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