Comparative effectiveness of oral pharmacologic interventions for knee osteoarthritis: A network meta-analysis

Jung, Sun‐Young; Jang, Eun Jin; Nam, Seoung Wan; Kwon, Hyuk Hee; Im, Seul Gi; Kim, Dam; Cho, Soo-Kyung; Kim, Dalho; Sung, Yoon‐Kyoung

doi:10.1080/14397595.2018.1439694

Cited by 35 publications

(32 citation statements)

References 20 publications

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“…In our sample, the most common drug pairs involving NSAID TDs were aceclofenac plus meloxicam, celecoxib plus aceclofenac, and celecoxib plus meloxicam (Table 2). One possible explanation of TD is that physicians may have expected additional beneficial effects from combining selective cyclooxygenase 2 (COX‐2) inhibitors with other NSAIDs, since in a recent network meta‐analysis aceclofenac had been reported to be effective in the higher pain intensity group (19). However, because the use of 2 concurrent NSAIDs may increase the risk of adverse events, this duplication is one of the most common criteria for potentially inappropriate prescribing, as in the Prescribing Optimally in Middle‐aged People’s Treatments criteria (20) and in the Screening Tool of Older Persons’ Potentially Inappropriate Prescriptions (STOPP) criteria (21).…”

Section: Discussionmentioning

confidence: 99%

Effect of a Nationwide Real‐Time Drug Utilization Review System on Duplicated Nonsteroidal Antiinflammatory Drug Prescriptions in Korea

Jung

Jang

Choi

et al. 2020

Arthritis Care & Research

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Objective Since January 2013, a nationwide drug utilization review (DUR) system for therapeutic duplication (TD) of nonsteroidal antiinflammatory drugs (NSAIDs) has been implemented in Korea. Our objective was to perform an interrupted time series study to assess changes in the pattern of NSAIDs use in knee osteoarthritis patients after implementation of the regulations. Methods We compared the prescribing patterns in 2012 and 2013 by means of an interrupted time series study, using the Health Insurance Review and Assessment Service database. TD was defined as use of concurrent NSAIDs either on the same or on different prescriptions for >3 days in a patient. Level change and trend change (with 95% confidence intervals [95% CIs]), and absolute and relative changes in the proportion of TDs, were estimated using segmented regression models. Multivariable logistic regression models were used to explore patient and provider characteristics associated with the TDs. Results Approximately 2.5 million patients were prescribed NSAIDs in both 2012 and 2013. The proportion of TDs before and after introduction of the DUR system was 7.4% and 5.6%, respectively. Overall, an absolute reduction of 89% and a relative reduction of 30% in TDs were observed. In the postregulation period, older patients, medical aid subscribers (odds ratio [OR] 1.87 [95% CI 1.84, 1.90]), and veterans (OR 3.28 [95% CI 3.10, 3.46]) were most likely to receive NSAID TDs. Conclusion The prescription of NSAID TDs decreased with the introduction of the nationwide DUR system. Continuous adherence to the DUR regulations and safety monitoring are needed, especially with the elderly, medical aid subscribers, and veterans.

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Section: Discussionmentioning

confidence: 99%

Effect of a Nationwide Real‐Time Drug Utilization Review System on Duplicated Nonsteroidal Antiinflammatory Drug Prescriptions in Korea

Jung

Jang

Choi

et al. 2020

Arthritis Care & Research

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“…и соавт. [17] выполнили сравнительную оценку эффективности эторикоксиба, ацеклофенака, пироксикама и мелоксикама по сравнению с другими НПВП, ацетаминофеном и трамадолом, которые не вошли в предыдущие опубликованные сетевые метаанализы. По влиянию на боль (WOMAC) все препараты оказывали значимый клинический эффект, включая плацебо.…”

Section: эффективность эторикоксиба при остеоартритеunclassified

Etoricoxib in the treatment of osteoarthritis

Аникин¹,

Алексеева²

2020

Medicinskij sovet

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Osteoarthritis (OA) is one of the most common diseases of the musculoskeletal system.The main symptoms of osteoarthritis are pain, stiffness, joint swelling. According to epidemiological studies, about one-third of the chronic moderate and severe pain is associated with OA. Currently, OA is considered as a multifactorial disease resulting from the interaction of various genetic, biological, mechanical, and metabolic factors. Inflammation plays a central role in development and progression of ОА. In patients with OA, histological studies of the synovial membrane detected signs of chronic inflammation. The level of some proinflammatory cytokines may increased and the level of anti-inflammatory cytokines may decreased in blood serum, synovial fluid and joint tissue. Also, adaptive immune cell responses are detected in the joint tissues in patients of OA. Due to its high effectiveness, non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in OA. Oral or local forms of NSAIDs are the drugs of choice in the initial stages of therapy in all guidelines. Etoricoxib is a selective inhibitor of cyclooxygenase 2 (COX-2) and is used for the treatment of OA and other rheumatic diseases. The article discusses the use of etoricoxib in patients with OA.

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“…Данный факт был продемонстрирован в работе S. Jung и соавт. [57], которые провели метаанализ 44 РКИ (n = 19 045), в которых изучалась эффективность НПВП у пациентов с ОА коленного сустава. Динамика индекса WOMAC в среднем оказалась наиболее значимой у пациентов, получавших эторикоксиб, -2,3, в сравнении с напроксеном -1,97, целекоксибом -1,48 и диклофенаком -0,97.…”

Section: нестероидные противовоспалительные препаратыunclassified

Spinal Osteoarthritis as a Cause of Chronic Low Back Pain

Каратеев¹,

Davydov

Яхно

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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Хроническая неспецифическая боль в нижней части спины (ХНБС) представляет серьезную медицинскую и социальную проблему, являясь одной из основных причин инвалидизации и значительного снижения качества жизни людей в современной популяции. Разработка эффективных методов лечения ХНБС требует совместных усилий представителей разных медицинских специальностей: терапевтов, ревматологов, неврологов, нейрохирургов и реабилитологов. Одной из частых причин развития ХНБС следует считать остеоартрит фасеточных и крестцово-подвздошных суставов. Авторы рассматривают вопросы патогенеза и клинических проявлений, проблемы диагностики, а также различные подходы к лечению данной патологии. На основании собственного опыта и анализа данных литературы определены ряд положений, которые в дальнейшем могут использоваться для формирования рекомендаций по лечению и реабилитации больных с ХНБС. Ключевые слова: хроническая неспецифическая боль в спине; остеоартрит; фасеточные суставы; крестцовоподвздошные суставы; нестероидные противовоспалительные препараты; глюкокортикоиды; гиалуроновая кислота; радиочастотная денервация.

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Comparative effectiveness of oral pharmacologic interventions for knee osteoarthritis: A network meta-analysis

Abstract: In the overall analysis, etoricoxib, celecoxib, and aceclofenac had the highest rankings for improving WOMAC pain. The ability to improve knee OA symptoms may differ depending on baseline pain and radiologic features.

Cited by 35 publications

References 20 publications

Effect of a Nationwide Real‐Time Drug Utilization Review System on Duplicated Nonsteroidal Antiinflammatory Drug Prescriptions in Korea

Effect of a Nationwide Real‐Time Drug Utilization Review System on Duplicated Nonsteroidal Antiinflammatory Drug Prescriptions in Korea

Etoricoxib in the treatment of osteoarthritis

Spinal Osteoarthritis as a Cause of Chronic Low Back Pain

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