Comparative effectiveness of first‐line radiofrequency ablation versus surgical resection and transplantation for patients with early hepatocellular carcinoma

Abstract

Although RFA frequently is used as first-line treatment of HCC tumors measuring as large as 50 mm, it is associated with worse results than RXN or TXP for tumors measuring >30 mm. To the best of the authors' knowledge, the results of the current study are the first to demonstrate that although RFA is an appropriate option for patients with HCC tumors measuring ≤30 mm, its use for tumors even slightly larger than 30 mm is associated with inferior outcomes. Cancer 2017;123:1817-1827. © 2017 American Cancer Society.

The power of tumor sizes in predicting the survival of solitary hepatocellular carcinoma patients

“…The general population was categorized into three subgroups with two cut‐off points in tumor sizes, 30 mm and 50 mm, which were adopted to define small HCC and acted as tumor size limitations between RFA and LT . Consequently, there were three subgroups of patients: ≤30 mm group, 31‐50 mm group, and >50 mm group.…”

“…According to related literature, the minimum ablative margin of RFA was proposed to be 10 mm. On the basis of the standard killzone as 50 mm, in order to achieve eradication theoretically, the maximum tumor size in RFA patients should be 30 mm, which has been demonstrated by many clinical reports . Although the optimal cut‐off value in tumor size for RFA is still controversial, it is convincing that tumor size has a remarkable influence on the outcome of RFA, which was supported by this study as well.…”

“…On the basis of the standard killzone as 50 mm, in order to achieve eradication theoretically, the maximum tumor size in RFA patients should be 30 mm, which has been demonstrated by many clinical reports . Although the optimal cut‐off value in tumor size for RFA is still controversial, it is convincing that tumor size has a remarkable influence on the outcome of RFA, which was supported by this study as well. Furthermore, current criteria for LT, such as the Milan criteria and United Network for Organ Sharing (UNOS) criteria, put emphasis on the absence of macrovascular invasion.…”

Transarterial chemoembolization plus multi-imaging–guided radiofrequency ablation for elimination of hepatocellular carcinoma nodules measuring 3.1 to 5.0 cm: a single-center study

“…For tumors even 1 mm larger than 3 cm, a significant increase in local recurrence and lower recurrence-free and disease-free survival rates are found in association with RFA when compared with surgical resection or transplantation. 5 Therefore, for HCC nodules of >3 cm, how to decrease the local recurrence rate and improve the elimination rate in RFA remains a challenging problem and may have a strong effect on the therapeutic outcome.…”

Radyofrekansın kas iskelet sistemi hastalıklarında kullanımı

“…Pulse RFA'da elektrod ucunda yaklaşık 42°C'lere çıkan ısı depolanması gösterilmiş olmakla beraber, ağrıyı azaltıcı etkisi ve nöral dokuyu Vallerian dejenerasyonuna uğratma-dan kesme mekanizması tam olarak açık değildir. [6][7][8] Biz de, özellikle faset eklem blokajı işlemlerinde, servikal bölge için pulse RFA uygulamaktayız. Renal, karaciğer, akciğer tümörleri gibi birçok iç organ (visseral) tümörlerinde, genel durum bozukluğu olan hastalarda ağrı ve bazı semptomların geriletilmesinde ve ameliyat edilemeyen durumlarda dahi uygulama yeri mevcuttur.…”