Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials

Recchia, Francesco; Leung, Chit K.; Chin, Edwin C.; Fong, Daniel Yee Tak; Montero, David; Cheng, Calvin Pak-Wing; Yau, Suk Yu; Siu, Parco M.

doi:10.1136/bjsports-2022-105964

Cited by 25 publications

(21 citation statements)

References 39 publications

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“…A more recent network meta‐analysis of 21 trials among individuals with non‐severe depression comparatively assessed the effectiveness of exercise, antidepressants, and combined treatments. All treatments were beneficial, but combined treatments were not superior to the individual treatments 31 . While our study was cross‐sectional, there were overall significant associations between higher MVPA and lower depression symptoms, but associations were stronger among those taking antidepressant medication.…”

Section: Discussionmentioning

confidence: 56%

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Depression, happiness, and satisfaction with life in women newly diagnosed with breast cancer: Associations with device‐measured physical activity and sedentary time

et al. 2023

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BackgroundFew studies have examined depression after a cancer diagnosis and before initiating adjuvant or neoadjuvant systemic treatments. In this study, we present baseline data on device‐measured physical activity, sedentary behaviour, depression, happiness, and satisfaction with life in newly diagnosed breast cancer survivors.PurposeTo examine associations of accelerometer‐assessed physical activity and sedentary time with depression symptoms and prevalence, happiness, and satisfaction with life.MethodsShortly after diagnosis, 1425 participants completed depression, happiness, and satisfaction with life measures and wore an ActiGraph® device on their hip to measure physical activity and the activPALTM inclinometer on their thigh for 7 days to measure sedentary time (sitting/lying) and steps (1384 completed both device measures). ActiGraph® data were analysed using a hybrid machine learning method (R Sojourn package, Soj3x), and activPALTM data using activPALTM algorithms (PAL Software version 8). We used linear and logistic regression to examine associations of physical activity and sedentary time with depression symptom severity (0–27) and depression prevalence, happiness (0–100), and satisfaction with life (0–35). For the logistic regression analysis, we compared participants with none‐minimal depression (n = 895) to participants with some depression (that is, mild, moderate, moderately‐severe, or severe depression [n = 530]).ResultsParticipants reported a mean depression symptom severity score of 4.3 (SD = 4.1), a satisfaction with life score of 25.7 (SD = 7.2), and a happiness score of 70 (SD = 21.8). Higher moderate‐to‐vigorous physical activity (MVPA) was associated with reduced depression symptom severity scores (β = −0.51, 95% CI: −0.87 to −0.14, p = 0.007). A 1 hour increase in MVPA was associated with a reduced odds of at least mild or worse depression by 24% (Odds Ratio [OR] = 0.76, 95% CI: 0.62–0.94, p = 0.012). Higher daily step counts were associated with lower depression symptom severity scores (β = −0.16, 95% CI: −0.24 to −0.10, p < 0.001). Perceptions of happiness was associated with higher MVPA (β = 2.17, 95% CI: 0.17–4.17, p = 0.033). Sedentary time was not associated with depression severity, but higher sedentary time was associated with lower perceptions of happiness (β = −0.80, 95% CI: −1.48 to −0.11, p = 0.023).ConclusionsHigher physical activity was associated with fewer depression symptom severity scores and reduced odds of mild or worse depression in women newly diagnosed with breast cancer. Higher physical activity and daily step counts were also associated with stronger perceptions of happiness and satisfaction with life, respectively. Sedentary time was not associated with depression symptom severity or odds of having depression, but was associated with stronger perceptions of happiness.

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Section: Discussionmentioning

confidence: 56%

“…All treatments were beneficial, but combined treatments were not superior to the individual treatments. 31 While our study was cross-sectional, there were overall significant associations between higher MVPA and lower depression symptoms, but associations were stronger among those taking antidepressant medication.…”

Section: Discussionmentioning

confidence: 57%

Depression, happiness, and satisfaction with life in women newly diagnosed with breast cancer: Associations with device‐measured physical activity and sedentary time

et al. 2023

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“…Recchia F, Leung CK, Chin EC et al Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine 2022 1…”

Section: Originalpublikationmentioning

confidence: 99%

“…Wie effektiv körperliches Training bei moderater Depression tatsächlich ist und wie es im Vergleich zu pharmakologischen Substanzen abschneidet, hat eine jüngst im British Journal of Sportsmedicine veröffentliche Netzwerk-Meta-Analyse (NMA) untersucht 1 .…”

Section: Originalpublikationunclassified

Vergleich der Wirksamkeit von Bewegung und Antidepressiva bei leichter bis moderater Depression: eine Netzwerk-Meta-Analyse

2023

B&G Bewegungstherapie und Gesundheitssport

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“…A recent systematic review and network meta-analysis of 21 randomised controlled trials ( n = 2,551) has examined the comparative effectiveness of exercise, antidepressants and their combination for alleviating depressive symptoms in adults with non-severe depression ( 22 ). No differences in therapeutic effectiveness were found between the three interventions, with all treatments being more beneficial than controls.…”

Section: Antidepressant Efficacy Of Exercise In Randomised Controlled...mentioning

confidence: 99%

Sport and exercise as medicine in the prevention and treatment of depression

Lange

Nakamura²,

Lange³

2023

Front. Sports Act. Living

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Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials

Cited by 25 publications

References 39 publications

Depression, happiness, and satisfaction with life in women newly diagnosed with breast cancer: Associations with device‐measured physical activity and sedentary time

Depression, happiness, and satisfaction with life in women newly diagnosed with breast cancer: Associations with device‐measured physical activity and sedentary time

Vergleich der Wirksamkeit von Bewegung und Antidepressiva bei leichter bis moderater Depression: eine Netzwerk-Meta-Analyse

Sport and exercise as medicine in the prevention and treatment of depression

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