Comparative Effectiveness of Cyanoacrylate Bioadhesives and Monofilament Suture in Wound Healing: A Histopathological and Physicochemical Study in New Zealand White Rabbit

Abstract

Comparative performance of suture and cyanoacrylate adhesives of different alkyl chain length for wound healing were compared in-vivo in New Zealand White rabbits. The alkyl chain length of the cyanoacrylate adhesive determines its effectiveness in tissue repair. The n-butyl cyanoacrylate (BCN) adhesive is very aggressive on the rabbit skin due to high exothermal reaction whereas wound closures with ethyl cyanoacrylate (ECN) and n-octyl cyanoacrylate (OCN) are adequate and similar. No significant alterations were found in the standard biochemical and haematological parameters test. When ECN and OCN adhesives are used, the wounds close with little inflammation, the edges are not separated and the tissues throughout the joined areas and nearby are normal. However, due to BCN stiffness, closed wounds show opened edges and intense inflammation. ECN and OCN adhesives present advantages vs. suture, i.e. less time for application, good confrontation of both sides of the incision, immediate haemostasis, less inflammation and absence of infection.

Adhesive Cements That Bond Soft Tissue Ex Vivo

“…Many of the proposed adhesives utilize crosslinking initiators that may be toxic or unsuited for specific applications (i.e., photoinitiation [24], or aldehyde crosslinking, which may elicit an immune response [25]), and weaken rapidly in liquids [26]. For example, tissues repositioned with acrylate-based adhesives may heal better than with sutures [27], yet acrylate glues can elicit a fibrotic response, and weaken under wet-field conditions [21]. In comparison, fibrin glues exhibit excellent histocompatibility, but are mechanically much weaker (10–50 kPa [19,28]).…”