Comparative Effectiveness of Behavioral Interventions on Quality of Life for Older Adults With Mild Cognitive Impairment

Abstract

This cluster randomized, multicomponent comparative effectiveness trial compares the incremental effects of combinations of 5 behavioral interventions on outcomes of highest importance to patients with mild cognitive impairment.

Comparative Efficacy of Multicomponent Behavioral Interventions for Mild Cognitive Impairment

“…The results of the study by Chandler et al 1 are also consistent with those of a 12-month RCT comparing cognitive training with physical activity (resistance training) in older adults with MCI. 6 In that study, resistance training was found to significantly improve global cognition, executive function, and verbal memory; however, the benefits of cognitive training were limited to the domain of memory.…”

Procedural Learning in Individuals with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia: a Systematic Review and Meta-analysis

“…Procedural learning in AD dementia and aMCI has important clinical implications (De Vreese et al, 2001;Greenaway et al, 2008;Harrison et al, 2007;Van Tilborg et al, 2007), for instance, for studies aiming to build on procedural memory to help compensate for memory loss (Greenaway et al, 2008;Chandler et al, 2019). Our findings suggest that in combined analysis comparing AD dementia and aMCI samples to health controls, procedural learning differences are statistically and clinically trivial, and thereby suggest no contra-indications for the use of procedural memory in efforts to compensate for areas of impaired declarative memory.…”

Design and Feasibility of a Randomized Controlled Pilot Trial to Reduce Exposure and Cognitive Risk Associated With Advanced Glycation End Products in Older Adults With Type 2 Diabetes

“…In the face-to-face screening, 65% did not meet the inclusion criteria and 58% of those screen failures were due to normal cognition. Low rates of recruitments of MCI participants from both community ( 52 ) and clinic settings ( 53 ) and the low sensitivity of SMCs alone to find eligible participants have been shown in prior studies. A community-based trial found that only 44% of those who applied with memory concerns following newspaper advertisement had MCI while 47% were classified with normal cognition in the tests with an average MOCA of 27 ( 52 ).…”

“…Other AGEs-lowering clinical trials ( 19 ) experienced a much higher withdrawal rate (27%) over the course of 1 year. Similarly, another behavioral intervention study in elderly with MCI that included cognitive training, yoga support groups, and wellness education reported a 17% dropout at 1 year ( 53 ). Our low attrition rate may be due to the intense follow up during the 6-month study, which helped participants maintain the guidelines and to ask questions about their interpretation of the guidelines (e.g., “can I use the oven if I cover the food?” “what food should I choose to eat if I have an event next week,” etc.).…”