Comparative Effect of Vitamins A and E on Gasoline Vapours-Induced Haematotoxicity and Weight-Loss in Male Rats

Uboh, F. E.; Akpanabiatu, M. I.; Alozie, Y.; Edet, E. E.; Ndem, Jessie Idongesit; Ebong, P. E.

doi:10.3923/ijp.2009.215.221

Cited by 19 publications

(14 citation statements)

References 21 publications

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“…Salah satu antioksidan eksogen adalah vitamin E (14) Vitamin E (α-tokoferol) sebagai antioksidan larut lemak, menjadi antioksidan utama dalam membran sel dengan cara melindungi komponen membran sel dari oksidasi radikal bebas. (15)(16)(17)(18) Reaktivitas hidrogen phenolik pada C-6 kelompok hidroksil α-tokoferol akan menstabilkan elektron tidak berpasangan pada radikal bebas. (19) AKG 2013 untuk vitamin E adalah 15 IU (20) dan dosis lebih tinggi diyakini diperlukan untuk pencegahan penyakit dan promosi kesehatan, dosis suplementasi yang umum digunakan adalah adalah 100, 200, 400, dan 800 IU.…”

Section: Pendahuluanunclassified

Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Roziana¹,

Subagio

Suhartono

et al. 2016

JGI

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Section: Pendahuluanunclassified

Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Roziana¹,

Subagio

Suhartono

et al. 2016

JGI

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“…Moreover, various substances have been used as counter measures to crude oil toxicities. These substances include various vitamins [21,22,23,24] organic and inorganic substances [9,5,25] and various plant extracts [9,26,27]. A review of literature shows that there is one important plant with a lot of curative ability [27].…”

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confidence: 99%

Effect of Methanolic Extract of Justicia Flava on Petroleum-Induced Reduced Cell Division and DNA Damage

Achuba

Mordi

2019

Galician med. j.

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The objective of this research was to determine the import of Justicia flava methanolic extract against petroleum-stimulated reduced cell division and DNA fragmentation. Materials and Methods. Ninety rats were distributed and treated as follows for thirty days: Group A - normal diet; Group B - normal feed + 100mg/kg bwt of Justicia flava methanolic extract; Group C - normal feed + 200mg/kg bwt of Justicia flava methanolic extract; Group D - normal feed + 300mg/kg bwt of Justicia flava methanolic extract; Group E - normal feed + 250 mg/kg bwt of standard ascorbic acid; Group F - crude oil-tainted feed; Group G - crude oil-tainted feed + 250 mg/kg bwt of standard ascorbic acid; Group H - crude oil-tainted feed + 100mg/kg bwt of Justicia flava methanolic extract; Group I - crude oil-tainted feed + 200mg/kg bwt of Justicia flava methanolic extract. After thirty days, the rats were sacrificed under chloroform sedation and the liver and kidney were collected for cellular analysis via standard protocols. Results. The results showed that administration of Justicia flava methanolic extract decreased petroleum-induced reduced cell division and DNA damage in the liver and kidney of experimental rats. Justicia flava methanolic extract is potent antidote for petroleum-induced DNA damage in the liver and kidney of rats. Conclusions. It is no doubt that ingestion of petroleum-tainted diet could culminate in DNA damage in organs and tissues of animals. However, the administration of Justicia flava methanolic extract was found to prevent this damage in renal and liver cells of experimental rats.

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“…Hematological examination showed that the Salmonella-infected mice (group 2) developed anemia, monocytosis and lymphocytosis.The data presented in Tables 2 and 3 show the effect of Salmonella enteri-caserovarTyphimurium infection and treatment with different doses of ethanolic extracts of propolis on hematological parameters. Hematological parameters of an organism are affected by a variety of different factors [7,14,26,27], with typhoid fever causing severe hematological changes, include anemia, leucopenia and eosinophilia [5]. Salmonella enterica serovar Typhimurium infection significantly decreased the mean levels of RBC, Hb, PCV, MCV, MCH and MCHC.…”

Section: Resultsmentioning

confidence: 99%

Effect of propolis extract on hematotoxicity and histological changes induced by Salmonella enterica serovar Typhimurium in BALB/c mice

Kalia

Kumar

Harjai

2016

ARCH BIOL SCI BELGRA

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Typhoid fever, a life-threatening disease, causes several pathological changes due to the involvement of one or more organs. In the present study, the effect of typhoid on hematological indices and spleen histology in infected mice were investigated. The ameliorative efficacy of the ethanolic extract of propolis was tested and compared with treatment with the typhoid drug,cefixime. BALB/c mice were divided into six groups: group1 was the normal control, group 2 was infected with Salmonella enteric serovar Typhimurium, group 3 was Salmonella infected and treated with cefixime, groups4 and 5 were Salmonella-infected mice treated with 100 mg and 300 mg of propolis respectively. Group 6 was given only 300 mg propolis without infection. Mice were killed after completion of treatment and examination of spleen histology and hematological studies were performed. Significant differences were observed in the propolis-treated group of mice as compared to the infected group without antibiotic, further confirming the ameliorative effect of propolis on Salmonella enterica serovar Typhimurium-induced toxicity in mice.

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Comparative Effect of Vitamins A and E on Gasoline Vapours-Induced Haematotoxicity and Weight-Loss in Male Rats

Cited by 19 publications

References 21 publications

Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Effect of Methanolic Extract of Justicia Flava on Petroleum-Induced Reduced Cell Division and DNA Damage

Effect of propolis extract on hematotoxicity and histological changes induced by Salmonella enterica serovar Typhimurium in BALB/c mice

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