Comparative Effect of Treadmill Exercise on Mature BDNF Production in Control versus Stroke Rats

Quirié, Aurore; Hervieu, Marie; Garnier, Philippe; Demougeot, Céline; Mossiat, Claude; Bertrand, Nathalie; Martin, Alain; Marie, Christine; Prigent‐Tessier, Anne

doi:10.1371/journal.pone.0044218

Cited by 69 publications

(56 citation statements)

References 43 publications

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“…Poststroke exercise and EE also increase expression of growth-associated proteins such as growth-associated protein 43 [49], microtubule-associated protein 2 [44], and netrin (along with the associated deleted in colorectal cancer receptor) [50], as well as markers of synaptogenesis [46,51,52]. Such proteins are involved in axonal sprouting, dendritic complexity, and spine growth [4], phenomena occurring in the peri-and contralesional cortex of functionally recovered animals [14,53].…”

Section: How Do Exercise and Enrichment Enhance Plasticity And Recovery?mentioning

confidence: 99%

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

et al. 2016

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Improved stroke care has resulted in greater survival, but >50 % of patients have chronic disabilities and 33 % are institutionalized. While stroke rehabilitation is helpful, recovery is limited and the most significant gains occur in the first 2-3 months. Stroke triggers an early wave of gene and protein changes, many of which are potentially beneficial for recovery. It is likely that these molecular changes are what subserve spontaneous recovery. Two interventions, aerobic exercise and environmental enrichment, have pleiotropic actions that influence many of the same molecular changes associated with stroke injury and subsequent spontaneous recovery. Enrichment paradigms have been used for decades in adult and neonatal animal models of brain injury and are now being adapted for use in the clinic. Aerobic exercise enhances motor recovery and helps reduce depression after stroke. While exercise attenuates many of the signs associated with normal aging (e.g., hippocampal atrophy), its ability to reverse cognitive impairments subsequent to stroke is less evident. It may be that stroke, like other diseases such as cancer, needs to use multimodal treatments that augment complimentary neurorestorative processes.

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Section: How Do Exercise and Enrichment Enhance Plasticity And Recovery?mentioning

confidence: 99%

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

et al. 2016

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“…We previously showed that such a modality of physical training (treadmill activity with a horizontal position, 30 minutes/day, 18 m/minute, for 7 consecutive days) induced a mild increase in citrate synthase activity in skeleton muscles, did not change blood pressure in WKY rats and SHR, 13 and resulted in a twofold increase in mature BDNF levels in the cortex when induced in control Wistar rats. 14 …”

Section: Physical Trainingmentioning

confidence: 99%

Brain BDNF Levels Elevation Induced by Physical Training is Reduced after Unilateral Common Carotid Artery Occlusion in Rats

Banoujaafar

Hoecke

Mossiat

et al. 2014

J Cereb Blood Flow Metab

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We investigated the contribution of blood flow elevation in the cerebrovasculature to physical training-induced brain-derived neurotrophic factor (BDNF) levels elevation in the brain. Brain-derived neurotrophic factor protein levels were measured in the motor cortex 24 h after the last session of a forced treadmill walking (30 minutes a day, 18 m/minute for 7 consecutive days). Unilateral common carotid artery occlusion and modulation of exercise intensity (0 versus À 10% inclination of the treadmill) were used as strategies to reduce the (normal) elevation of flow in the cerebrovasculature occurring during exercise. Administration of N-nitro-L-arginine methyl ester (L-NAME, 60 mg/kg before each exercise sessions) and genetic hypertension (spontaneously hypertensive rats) were used as approaches to reduce stimulation of nitric oxide production in response to shear stress elevation. Vascular occlusion totally and partially abolished the effect of physical training on BDNF levels in the hemisphere ipsilateral and contralateral to occlusion, respectively. BDNF levels were higher after high than low exercise intensity. In addition, both genetic hypertension and L-NAME treatment blunted the effects of physical training on BDNF. From these results, we propose that elevation of brain BDNF levels elicited by physical training involves changes in cerebral hemodynamics.

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“…However, this therapy can only be administered to a small percentage of patients, and there is no effective treatment for improvement of functional recovery in the post-ischemic phase [7], [8]. Functional recovery after stroke can potentially be induced by stimulation of endogenous neurogenesis [9].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Promotes Post-Stroke Functional Recovery via Enhancing Endogenous Neurogenesis in Mouse Focal Cerebral Ischemia

Kim

Ahn

et al. 2014

PLoS ONE

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To investigate the question of whether electroacupuncture (EA) promotes functional recovery via enhancement of proliferation and differentiation of neuronal stem cells (NSCs) in ischemic stroke, EA stimulation with 2 Hz was applied at bilateral acupoints to Baihui (GV20) and Dazhui (GV14) in middle cerebral artery occlusion (MCAO) mice. EA stimulation improved neuromotor function and cognitive ability after ischemic stroke. EA stimulation resulted in an increase in the number of proliferated cells, especially in the subventricular zone (SVZ) of the ipsilateral hemisphere. Although a very limited number of NSCs survived and differentiated into neurons or astrocytes, EA treatment resulted in a significant increase in the number of proliferative cells and differentiated cells in the hippocampus and SVZ of the ipsilateral hemisphere compared to MCAO mice. EA stimulation resulted in significantly increased mRNA expression of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). Protein levels of these factors were confirmed in the ipsilateral hippocampus and SVZ by immunohistochemical and Western blotting analyses. Expression of phosphorylated phosphatidylinositol-3-kinase, BDNF, and VEGF-mediated down-stream were enhanced by EA stimulation in newly formed neuroblasts. These results indicate that EA treatment after ischemic stroke may promote post-stroke functional recovery by enhancement of proliferation and differentiation of NSCs via the BDNF and VEGF signaling pathway.

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Comparative Effect of Treadmill Exercise on Mature BDNF Production in Control versus Stroke Rats

Cited by 69 publications

References 43 publications

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

Brain BDNF Levels Elevation Induced by Physical Training is Reduced after Unilateral Common Carotid Artery Occlusion in Rats

Electroacupuncture Promotes Post-Stroke Functional Recovery via Enhancing Endogenous Neurogenesis in Mouse Focal Cerebral Ischemia

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