Comparative effect of therapeutic and toxic doses of imipramine administration on the levels of norepinephrine, dopamine and serotonin in discrete regions of rat brain
Abstract:Levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) were estimated by HPLC in different regions of adult rat brain after feeding therapeutic (25 mg/kg) or toxic (100 mg/kg) doses of imipramine for 60 days. Imipramine (25 mg/kg) significantly enhanced the growth rate compared to control but the 100 mg/kg dose significantly reduced the body growth rate (but not brain weight) and in addition induced tremors, lethargy, hyperpigmentation and alopecia.Imipramine, 25 mg/kg, consistently decrea… Show more
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