Comparative Effect of Tempe and Soymilk on Fasting Blood Glucose, Insulin Level and Pancreatic Beta Cell Expression (Study on Streptozotocin-Induced Diabetic Rats)

Bintari, Siti Harnina; Putriningt, Natalia Desy; Nugraheni, Kartika; Widyastiti, Nyoman Suci; Dharmana, Edi; Johan, Andrew

doi:10.3923/pjn.2015.239.246

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Administration of FETAA dose 20 mg/100 g BW showed an increase in insulin level compared to the normal group. This result is consistent with research that giving tempeh and soy fermented milk is known to increase insulin secretion and reduce blood glucose levels in diabetic rats induced with streptozotocin [21].…”

Section: Discussionsupporting

confidence: 93%

The effect of fermented tempeh aerobic anaerobic (FETAA) on pancreatic duodenal homeobox 1 (Pdx1) gene expression and HOMA-beta index in diabetic mice

Wicaksono¹,

Prasetyastuti²,

Hastuti³

et al. 2021

actabioina

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Background: Diabetes is a result of oxidative stress which causes the impaired function of pancreatic beta-cells. Fermented tempeh aerobic anaerobic (FETAA) containing gamma-aminobutyric acid and isoflavones can reduce oxidative stress in diabetes. Objective: The aim of this study is to evaluate FETAA in improving pancreatic β-cell function in diabetic mice. Methods: Twenty streptozotocin-induced diabetic mice, divided into four groups (n = 5 each group): DM, DM + FETAA 10 mg/100 g BW, DM + FETAA 20 mg/100 g BW, DM + FETAA 40 mg/100 g BW as well as normal group (n = 5). DM mice were treated with FETAA for 21 days. Fasting glucose was determined using the GOD-PAP method, while insulin level was determined by ELISA. The homeostasis model assessment of β-cell function (HOMA-β) was calculated using the HOMA2 calculator, and the Pdx1 mRNA level was determined by Real Time-PCR. Results: The DM mice group treated with FETAA had lower glucose levels than the DM mice group. FETAA dosage of 40 mg/100 g BW was able to reduce the highest blood glucose levels (p<0.05). DM mice group treated with FETAA had higher levels of insulin and HOMA-β than the DM mice group (p <0.05). Treatment of FETAA 10 mg/100 g BW produced the highest insulin content of 57.44 ± 8.132 pmol/L, while treatment of FETAA 40 mg/100 g BW had a HOMA-β value of 72.86 ± 21.85%. Pdx1 mRNA expression in group FETAA-treated DM mice was higher than the DM mice group, although it was not statistically significant (p> 0.05). Conclusion: FETAA could improve HOMA-β, blood glucose levels, but did not affect Pdx1 mRNA expression.

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Section: Discussionsupporting

confidence: 93%

The effect of fermented tempeh aerobic anaerobic (FETAA) on pancreatic duodenal homeobox 1 (Pdx1) gene expression and HOMA-beta index in diabetic mice

Wicaksono¹,

Prasetyastuti²,

Hastuti³

et al. 2021

actabioina

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“…Sedangkan kelompok glisitein adalah komponen minor (10%) dalam total isoflavon kedelai . Konsumsi kedelai dan tempe sebagai pangan fungsional terbukti membantu mengontrol kadar gula darah serta memiliki efek insulinotropik pada tikus yang diinduksi streptozotocin 33 .…”

Section: Nilai Isoflavonunclassified

Analisis Daya Terima Dan Kadar Isoflavon Fortem Dia_Tri Sebagai Dukungan Gizi Pasien Diabetes Melitus Tipe 2

Hidayat

Sugiarto

Wiboworini

2020

AMNT

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Background: Indonesia is the country with the sixth most DM sufferers in the world with the number of DM patients reaches 10.3 million people and are expected to increase annually. Dietary modifications combined with pharmacological interventions could be the main approach in the control of DM. FortemDia_Tri is a development of diet modification of Tempe flour-based and green beans as the main source of Isoflavone and other materials such as skim milk flour, red rice flour, canola oil, and maltodextrin are recommended for patients with type 2 DM.Purpose: The study aimed to analyse the power of 5 formula Fortem Dia_Tri and the value of isoflavones in the best formula allocated for a type 2 DM patient.Methods: The type of research used in this research was experimental by formulation of 5 formula Fortem Dia_Tri. Study subjects were 40 people to test acceptability of the formula. Analysis of isoflavone levels was performed using the HPLC method.Result: There was a significant difference in the receipt of both color, aroma, taste, viscosity, and overall with P value <0.001. Formula FD03 is the most preferred formula with a score of 6.6-7.2 (likes). Followed by the formula FD05 with the value of 5.75-6.34 (somewhat like), While FD01, FD02, FD03 in neutral categories. The value of isoflavone levels of the 2 best formulas was FD05 of 241.77719 μg/ml or in 60.44 mg isoflavone/250 ml, and followed by a FD03 of 174.39759 μg/ml or an offering of 34.87 mg of isoflavone/200 ml.Conclusion: The most preferred formula of panelist was the FD03 formula. The two best formulas have a level of isoflavones that were already in accordance with the needs of isoflavone per day for diabetes mellitus type 2 patients.ABSTRAKLatar Belakang : Indonesia merupakan negara dengan penderita Diabetes Melitus (DM) tipe 2 terbanyak ke enam di dunia yang mencapai 10,3 juta jiwa. Modifikasi diet yang dikombinasikan dengan intervensi farmakologis bisa sebagai pendekatan utama dalam pengendalian DM. Fortem Dia_Tri merupakan pengembangan modifikasi diet sebagai dukungan gizi tambahan berbahan dasar tepung tempe dan kacang hijau sebagai sumber utama isoflavon dan bahan lain seperti tepung susu skim, tepung beras merah, minyak canola, dan maltodekstrin yang direkomendasikan untuk pasien DM tipe 2.Tujuan :Menganalisis daya terima 5 formula Fortem Dia_Tri dan nilai isoflavon pada formula terbaik yang diperuntukkan untuk pasien DM tipe 2.Metode : Penelitian ini dilakukan pada bulan September-Oktober. Jenis penelitian yang digunakan pada penelitian ini ialah eksperimental dengan meracik 5 formula Fortem Dia_Tri. Subjek dalam penelitian ini adalah mahasiswa S2 Ilmu Gizi Universitas Sebelas Maret Surakarta sebanyak 40 orang untuk uji daya terima berdasarkan warna, aroma, rasa, kekentalan, dan keseluruhan. Skala yang digunakan untuk uji hedonik adalah 9 skala. Analisis kadar isoflavon menggunakan metode High Performance Liquid ( HPLC).Hasil : Terdapat perbedaan daya terima yang signifikan baik warna, aroma, rasa, kekentalan, dan keseluruhan dengan p value <0,0001 Formula FD03 adalah formula yang paling disukai dengan skor 6,6-7,2 (suka). Disusul dengan formula FD05 dengan nilai 5,75-6,34 (agak suka), sedangkan FD01, FD02, FD03 dalam kategori netral. Nilai kadar isoflavon dari 2 formula terbaik yaitu FD05 sebesar 241,77719 μg/ml atau persaji 60,44 mg isoflavon /250 ml, dan diikuti FD03 sebesar 174,39759 μg/ml atau persaji 34,87 mg isoflavon / 200 ml.Kesimpulan : Formula yang paling disukai panelis adalah formula FD03. Kedua formula terbaik (FD03 dan FD05) mempunyai kadar isoflavon yang sudah sesuai dengan kebutuhan isoflafon per hari untuk pasien diabetes melitus tipe 2.

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“…Konsumsi kedelai dan tempe terbukti dapat membantu mengontrol kadar gula darah serta memiliki efek insulinotropik pada tikus yang diinduksi streptozotocin (10). Penelitian tersebut membuktikan bahwa konsumsi kedelai pada tikus diabetes terbukti dapat membantu mengontrol kadar profi l lipid secara signifi kan. Penelitian serupa yang membandingkan efektivitas doenjang, pasta kedelai hasil fermentasi dari Korea Selatan, dengan kedelai memberikan kesimpulan yang sama dengan penelitian ini.…”

Section: Bahasanunclassified

“…Isoflavon tempe dapat meningkatkan apoptosis dan menurunkan aktivitas proliferasi pada kanker payudara (9). Selain itu, isofl avon tempe juga dapat mengontrol kadar gula darah dan melindungi sel beta pankreas dari kerusakan lebih lanjut akibat diabetes melitus (10). Berdasarkan latar belakang tersebut, penelitian ini bertujuan untuk menganalisis efek konsumsi tempe dan susu kedelai terhadap parameter profi l lipid pada tikus yang dikondisikan hiperglikemia.…”

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Aktivitas antidislipidemia Tepung tempe dan susu kedelai pada profil lipid tikus diabetes yang diinduksi streptozotocin

Nugraheni

Bintari

2017

IJND

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Comparative Effect of Tempe and Soymilk on Fasting Blood Glucose, Insulin Level and Pancreatic Beta Cell Expression (Study on Streptozotocin-Induced Diabetic Rats)

Cited by 12 publications

References 32 publications

The effect of fermented tempeh aerobic anaerobic (FETAA) on pancreatic duodenal homeobox 1 (Pdx1) gene expression and HOMA-beta index in diabetic mice

The effect of fermented tempeh aerobic anaerobic (FETAA) on pancreatic duodenal homeobox 1 (Pdx1) gene expression and HOMA-beta index in diabetic mice

Analisis Daya Terima Dan Kadar Isoflavon Fortem Dia_Tri Sebagai Dukungan Gizi Pasien Diabetes Melitus Tipe 2

Aktivitas antidislipidemia Tepung tempe dan susu kedelai pada profil lipid tikus diabetes yang diinduksi streptozotocin

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