Comparative effect of lercanidipine and nifedipine gastrointestinal therapeutic system on ankle volume and subcutaneous interstitial pressure in hypertensive patients: a double-blind, randomized, parallel-group study

Fogari, Roberto; Malamani, G. D.; Zoppi, Annalisa; Preti, Paola; Vanasia, Alessandro; Fogari, Elena; Mugellini, Amedeo

doi:10.1016/s0011-393x(00)90012-2

Cited by 53 publications

(42 citation statements)

References 27 publications

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“…14,22 In both treatment groups, although at different degrees, younger patients showed the greatest increase in PSTP and the lowest increase in AFV, whereas the contrary was observed in the older patients. Such a different age-related response to the same stimulus for oedema formation confirms some previous observations by ourselves 23 and relates probably to the different structural characteristics of tissues at various ages. Younger patients have greater tissue integrity and more elastic tissue components so that the tendency toward fluid filtration may be counteracted by pronounced tension development in elastic tissue components with consequent increase in PSTP, that limits the AFV increase.…”

Section: Discussionsupporting

confidence: 90%

Effect of benazepril addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

et al. 2003

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The aim of this study was to evaluate the effect of benazepril addition to amlodipine antihypertensive treatment on ankle-foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP), two objective measures of ankle oedema. A total of 32 mild to moderate essential hypertensives (DBP490 and o110 mmHg), aged 30-70 years were studied. After a 4-week placebo period, they were randomized to amlodipine 5 mg o.d. or benazepril 10 mg o.d. or amlodipine 5 mg plus benazepril 10 mg o.d. for 4 weeks, according to a crossover design. At the end of the placebo period and of each active treatment period, blood pressure,AFV and PSTP were evaluated. AFV was measured using the principle of water displacement. PSTP was assessed using a system, the subcutaneous pretibial interstitial enviroment with a water manometer. Both amlodipine and benazepril monotherapy significantly reduced SBP (À18.2 7 4 and À17.8 7 4 mmHg, respectively, Po0.01 vs baseline) and DBP (À12.1 7 3 and À11.7 7 3 mmHg, respectively, Po0.01); the reduction was increased by the combination (À24.2 7 5 mmHg for SBP, Po0.001 and À16.8 7 4 mmHg for DBP, Po0.001). Amlodipine monotherapy significantly increased both AFV (+17.1%, Po0.001 vs baseline) and PSTP (+56.6%, Po0.001 vs baseline). As compared to amlodipine alone, the combination produced a less pronounced increase in AFV (+5.5%, Po0.05 vs baseline and Po0.01 vs amlodipine) and PSTP (+20.5%, Po0.05 vs baseline and Po0.01 vs amlodipine). Ankle oedema was clinically evident in 11 patients with amlodipine monotherapy and in three patients with the combination. These results suggest that ACE-inhibitors partially counteract the microcirculatory changes responsible for Ca-antagonists-induced oedema formation.

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Section: Discussionsupporting

confidence: 90%

Effect of benazepril addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

et al. 2003

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“…36 Advancing age increases the likelihood of CCBinduced oedema; as the interstitial tissue ages, it is less able to counterbalance hydrostatically driven oedema and thus the elderly are more likely to have greater levels of CCB-induced oedema. 37 Furthermore, an upright posture also increases the hydrostatic pressure of the legs and can result in an increased incidence of CCB-induced oedema. 38 …”

Section: Mechanism Of Ccb-induced Oedemamentioning

confidence: 99%

Mitigation of calcium channel blocker-related oedema in hypertension by antagonists of the renin–angiotensin system

Sierra

2009

J Hum Hypertens

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This review is aimed at examining calcium channel blocker (CCB)-related oedema and how this can be attenuated through the use of agents that inhibit the renin-angiotensin system. CCBs are effective antihypertensive agents, but their propensity for causing oedema may reduce compliance. A review of the literature has indicated that the absolute incidence of this side effect is difficult to determine because reported rates vary widely, a factor that may stem from differences in the surveillance technique (active vs passive). In a recent trial incorporating active surveillance, 25% of patients who received amlodipine 10 mg per day experienced oedema. CCB-induced oedema is caused by increased capillary hydrostatic pressure that results from preferential dilation of pre-capillary vessels. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) cause postcapillary dilation and normalize hydrostatic pressure, and are thus ideally suited for prevention/reversal of CCB-induced oedema. The efficacy of this strategy was proven using both subjective and objective techniques. ARB/CCB and ACEI/CCB combination therapy is also more effective than CCB monotherapy in controlling blood pressure. These combinations represent an important advance in the management of hypertension.

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“…Тем не менее, единственное проспективное, двойное слепое, рандомизированное исследование, выполненное на пожилых пациентах (60 лет и старше) с гипертензией I-II ст., также продемонстрировало значительно более высокую частоту развития перифе-рических отеков в группе амлодипина, по сравнению с группами лерканидипина и лацидипина (исследова-ние COHORT) [11]. В двух других исследованиях, использовавших метод объективной оценки (так назы-ваемая методика "вытеснения жидкости"), было пока-зано, что у лиц обоего пола лерканидипин вызывает отеки голеней достоверно реже, чем нифедипин ГИТС в дозе 30 мг и амлодипин в дозе 10 мг [21,22]. Причина более низкой частоты развития отеков голеней на фоне приема лерканидипина остается неясной.…”

Section: лерканидипин: лучший профиль переносимостиunclassified

Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine?

Burnier

Pruijm²,

Wuerzner³

2009

Expert Opinion on Drug Metabolism & Toxicology

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Comparative effect of lercanidipine and nifedipine gastrointestinal therapeutic system on ankle volume and subcutaneous interstitial pressure in hypertensive patients: a double-blind, randomized, parallel-group study

Cited by 53 publications

References 27 publications

Effect of benazepril addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

Effect of benazepril addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

Mitigation of calcium channel blocker-related oedema in hypertension by antagonists of the renin–angiotensin system

Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine?

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