Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet

Khan, B. A. H.; Ahmed, Tausif; Karim, Shahid; Monif, Tausif; Saha, Nilanjan; Sharma, Pankaj

doi:10.1007/bf03190587

Cited by 3 publications

(1 citation statement)

References 19 publications

(21 reference statements)

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“…Infatti, il cefaclor, nonostante oltre vent'anni di intenso utilizzo clinico, mantiene in Italia un'elevata attività antibatterica con bassi tassi di resistenze nei confronti dei patogeni che colpiscono le vie respiratorie in età pediatrica [40][41][42][43][44][45][46][47]. Somministrato per via orale, il cefaclor viene quasi totalmente assorbito, diffonde bene nei tessuti e raggiunge concentrazioni adeguate nei liquidi dell'orecchio medio, nelle tonsille, nelle mucose e nelle secrezioni delle vie respiratorie [48][49][50][51][52][53][54][55][56][57][58].…”

Section: Introduzioneunclassified

Pharmacoeconomic evaluation of cefaclor in the pharyngo-tonsillitis and acute otitis in children

Eandi

Giudice²

2006

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Pharyngotonsillitis (FT) and acute otitis media (OMA) are among the most frequent infectious diseases of the childhood and exact a heavy toll on the Italian national health service (INHS), families and society as a whole. In case of established or suspected bacterial origin, current treatment guidelines for FT recommend 5-10 days of oral antibiotics, chosen among available penicillins, cephalosporins, or macrolides. More controversial appears the systematical use of an antibiotic for OMAs, but prevalent expert opinion suggests use of the same agents. In this paper, an economical appraisal of five of the most prescribed oral antibiotics for these indications in Italy (cefaclor, amoxicyllin, amoxicyllin/clavulanate, clarithromycin and azithromycin) is provided. The evaluation was conducted through the development and implementation of two distinct models, constructed to reflect national treatment patterns of these infections. Clinical and economical data were obtained from several sources: literature review, including published meta-analyses, consultation of an expert panel and, most importantly, from the results of a specific questionnaire-based survey completed by 136 pediatricians, based throughout Italy. The models were run to conduct both cost-effectiveness and cost-minimization analyses, that consistently indicated cefaclor and amoxicyllin to be substantially equivalent in terms of total costs to the INHS and the Italian society, but significantly more convenient than amoxicyllin/clavulanate, claritrhomycin or azithromycin. Extensive probabilistic sensitivity analyses confirmed the robustness of this conclusion.

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Section: Introduzioneunclassified

Pharmacoeconomic evaluation of cefaclor in the pharyngo-tonsillitis and acute otitis in children

Eandi

Giudice²

2006

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Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations

Saleem,

Zamir,

Rasool

et al. 2024

Xenobiotica

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Do dietary interventions exert clinically important effects on the bioavailability of β-lactam antibiotics? A systematic review with meta-analyses

Wiesner,

Zagrodzki,

Paśko

2024

Journal of Antimicrobial Chemotherapy

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Background Managing drug–food interactions may help to achieve the optimal action and safety profile of β-lactam antibiotics. Methods We conducted a systematic review with meta-analyses in adherence to PRISMA guidelines for 32 β-lactams. We included 166 studies assessing the impact of food, beverages, antacids or mineral supplements on the pharmacokinetic (PK) parameters or PK/pharmacodynamic (PK/PD) indices. Results Eighteen of 25 β-lactams for which data on food impact were available had clinically important interactions. We observed the highest negative influence of food (AUC or Cmax decreased by >40%) for ampicillin, cefaclor (immediate-release formulations), cefroxadine, cefradine, cloxacillin, oxacillin, penicillin V (liquid formulations and tablets) and sultamicillin, whereas the highest positive influence (AUC or Cmax increased by >45%) for cefditoren pivoxil, cefuroxime and tebipenem pivoxil (extended-release tablets). Significantly lower bioavailability in the presence of antacids or mineral supplements occurred for 4 of 13 analysed β-lactams, with the highest negative impact for cefdinir (with iron salts) and moderate for cefpodoxime proxetil (with antacids). Data on beverage impact were limited to 11 antibiotics. With milk, the extent of absorption was decreased by >40% for cefalexin, cefradine, penicillin G and penicillin V, whereas it was moderately increased for cefuroxime. No significant interaction occurred with cranberry juice for two tested drugs (amoxicillin and cefaclor). Conclusions Factors such as physicochemical features of antibiotics, drug formulation, type of intervention, and patient’s health state may influence interactions. Due to the poor actuality and diverse methodology of included studies and unproportionate data availability for individual drugs, we judged the quality of evidence as low.

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Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet

Cited by 3 publications

References 19 publications

Pharmacoeconomic evaluation of cefaclor in the pharyngo-tonsillitis and acute otitis in children

Pharmacoeconomic evaluation of cefaclor in the pharyngo-tonsillitis and acute otitis in children

Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations

Do dietary interventions exert clinically important effects on the bioavailability of β-lactam antibiotics? A systematic review with meta-analyses

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