Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE−/− mice

Feng, Min; Zou, Zongyao; Zhou, Xia; Hu, Yinran; Ma, Hang; Xiao, Yali; Li, Xuegang; Ye, Xiaoli

doi:10.1016/j.intimp.2016.12.001

Cited by 28 publications

(29 citation statements)

References 39 publications

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“…Previous studies have demonstrated the therapeutic potential of berberine inhibiting atherosclerosis in vivo. Berberine administration significantly decreased the atherosclerotic plaque area in ApoE −/− mice [24]. In homocysteine thiolactone (HTL)-fed ApoE −/− mice, berberine promoted the stability of plaque in the artery by downregulating the oxidative stress [25].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Berberine for the Treatment of Atherosclerosis Based on Network Pharmacology

Xie

Zeng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Atherosclerosis is a common metabolic disease characterized by lipid metabolic disorder. e processes of atherosclerosis include endothelial dysfunction, new endothelial layer formation, lipid sediment, foam cell formation, plaque formation, and plaque burst. Owing to the adverse effects of first-line medications, it is urgent to discover new medications to deal with atherosclerosis. Berberine is one of the most promising natural products derived from traditional Chinese medicine. However, the panoramic mechanism of berberine against atherosclerosis has not been discovered clearly. In this study, we used network pharmacology to investigate the interaction between berberine and atherosclerosis. We identified potential targets related to berberine and atherosclerosis from several databases. A total of 31 and 331 putative targets for berberine and atherosclerosis were identified, respectively. en, we constructed berberine and atherosclerosis targets with PPI data. Berberine targets network with PPI data had 3204 nodes and 79437 edges. Atherosclerosis targets network with PPI data had 5451 nodes and 130891 edges. Furthermore, we merged the two PPI networks and obtained the core PPI network from the merged PPI network. e core PPI network had 132 nodes and 3339 edges. At last, we performed functional enrichment analyses including GO and KEGG pathway analysis in David database. GO analysis indicated that the biological processes were correlated with G1/S transition of mitotic cells cycle. KEGG pathway analysis found that the pathways directly associated with berberine against atherosclerosis were cell cycle, ubiquitin mediated proteolysis, MAPK signaling pathway, and PI3K-Akt signaling pathway. After combining the results in context with the available treatments for atherosclerosis, we considered that berberine inhibited inflammation and cell proliferation in the treatment of atherosclerosis. Our study provided a valid theoretical foundation for future research.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Berberine for the Treatment of Atherosclerosis Based on Network Pharmacology

Xie

Zeng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…In the present study, we investigated the effects of TSG on atherosclerotic rats. Considering plaque formation is a crucial characteristic of the progression of atherosclerotic disease [27], we first examined the pathological change in the aorta and evaluated the inhibitory effects of TSG on the atherosclerotic lesion in rats. Histopathological examinations revealed obvious lipid plaque beneath vascular intima in atherosclerotic rats.…”

Section: Discussionmentioning

confidence: 99%

Antiatherosclerosis Properties of Total Saponins of Garlic in Rats

Miao

Wang

Bai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Garlic has been proven effective in the prevention and treatment of atherosclerosis (AS), which is widely used as a food and medicine by people in daily life. Garlic saponins are the main active nonsulfur compounds of garlic, which have a variety of pharmacological activities against cardiovascular diseases. In this study, the antiatherosclerosis properties and mechanism of total saponins of garlic (TSG) in rats were explored. The AS animal model was established by a combination of high-fat feeding, intraperitoneal injection of vitamin D3, and ovalbumin-induced inflammation in SD rats. Then, the atherosclerotic rats were gavaged daily by TSG for 4 weeks. Administration of TSG markedly decreased atherosclerotic lesions in the aorta of atherosclerotic rats. TSG restored the serum lipid profile by significantly decreasing the lipid levels and had effective antioxidation by inhibiting the content of malondialdehyde (MDA) and restoring the reduced activity of superoxide dismutase (SOD). Additionally, the ratio of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) could be maintained in a relatively stable dynamic balance after administration of TSG to maintain the vascular homeostasis. In summary, TSG had therapeutic effects on AS, which are promising as functional foods or nutraceuticals for the prevention and treatment of AS.

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“…Three bioactive alkaloids have been isolated from Rhizoma coptidis, including berberine, coptisine, and jatrorrhizine. Berberine has numerous pharmacological effects with anti-diabetic, anti-inflammatory, anti-hypercholesterolemia, and cardioprotective properties [19][20][21][22][23]. Berberine displays beneficial actions in the treatment of insulin-resistant and hyperglycemic states by up-regulating adipose triglyceride lipase in adipocytes via activating adenosine 5 -monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway [24,25].…”

Section: Discussionmentioning

confidence: 99%

“…Berberine -anti-inflammatory [23,24]; -anti-hypercholesterolemia [21,22]; blood glucose-lowering [20]; -anti-obesity [21]; -cardioprotective [19]; and antioxidative [17] -inhibiting PPAR-γ and C/EBP-α [21]; increasing adipose triglyceride lipase [20]; -inhibiting NF-κB [23,24]; AMPK activation [22][23][24] Cell cultures; rodent models…”

Section: Rhizoma Coptidismentioning

confidence: 99%

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

et al. 2019

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The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve clinical outcomes of T2DM patients was still debated. Four studies comparing Tangminling vs. placebo treatment in T2DM patients were included and 767 T2DM patients were enrolled in our analyses. Tangminling treatment exhibited better efficacy than placebo in reducing hemoglobin A1c (HbA1c) (1.11 vs. 0.32%; pooled weighted mean difference [WMD]: 0.80; 95% confidence interval [CI]: 0.65–0.96; P<0.001), fasting plasma glucose (0.82 vs. −0.40 mM; WMD: 1.10; 95% CI: 0.56–1.64; P<0.001), 2-h postprandial glucose (2-hr PG) (2.81 vs. 1.11 mM; WMD: 1.80; 95% CI: 1.72–1.88; P<0.001), homeostatic model assessment-β level (4.28 vs. 0.41; WMD: 0.44; 95% CI: 0.27–0.61; P<0.001), waist circumference (WC) (1.04 vs. 0.36 cm; WMD: 0.78; 95% CI: 0.37–1.19; P<0.001) and body weight index (0.37 vs. 0.11 kg/m2; WMD: 0.30; 95% CI: −0.00 to 0.61; P=0.05). Tangminling pill might reduce glucose level and body weight and improve β-cell function in T2DM patients. Our study highlights the important role of Tangminling pill in the management of T2DM.

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Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE−/− mice

Cited by 28 publications

References 39 publications

Mechanisms of Berberine for the Treatment of Atherosclerosis Based on Network Pharmacology

Mechanisms of Berberine for the Treatment of Atherosclerosis Based on Network Pharmacology

Antiatherosclerosis Properties of Total Saponins of Garlic in Rats

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

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