We investigated the effect of mixing highâ and lowâenergy photon beams on the quality of intensityâmodulated radiation therapy (IMRT) plans for patients with prostate cancer. Three different plans for each of twenty patients were generated using either 6 MV or 15 MV alone, and both 6 and 15 MV beams. All the planning parameters, goals, and constraints were set to be identical except beam energy. The dose distributions were similar in terms of target coverage, conformity, and homogeneity regardless of beam energy. The normalV70Gy of rectal wall in 6 MV, 15 MV and mixedâenergy plans was 16.7%, 17.9%, and 16.3%, respectively, while normalV40Gy was 55.6%, 53.2%, and 50%. The mean dose to femoral heads in 6 MV, 15 MV, and mixedâenergy plans were 31.7 Gy, 26.3 Gy, and 26.2 Gy, respectively. The integral dose of 6 MV plans was 7% larger than those of 15 MV or mixedâenergy plans. These results indicated that mixedâenergy IMRT plans could take advantage of the dosimetric characteristics of lowâ and highâenergy beams. Even though the reduction of dose to the organs at risk may not be clinically relevant, mixing energy in an IMRT plan for deepâseated tumors can improve the overall plan quality.PACS number: 87.55.ne