Comparative Docking Analysis of Vitexin and Tamoxifen with EMT Marker

Abstract

Epithelial Mesenchymal Transition (EMT), is an evolutionary conserved developmental program, has been implicated in carcinogenesis and confers metastatic properties upon cancer cells by enhancing mobility, invasion and resistance to apoptotic stimuli. When EMT occur the connection between the cells were broken, their cytoskeleton was rearranged, and the ability of migration, invasion and apoptosis can be changed. Therefore it is of great significance for tumour invasion and metastasis via inhibition of EMT. Cancer metastasis is a significant target in clinical treatment. The present comparison study focuses on molecular docking analysis of vitexin -a well known flavone glucoside isolated from the roots of Vitex negundo and drug tamoxifen on EMT marker trans membrane protein E-cadherin. The results of molecular docking analysis determines the binding capacity of ligand on receptor, ability of stable complex formation and the role of ligand in modifying the action of receptor protein and shows that the vitexin can able to interact with E-cadherin in regulating the EMT process on controlling cancer progression.