Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis

Spitz, Élisabeth; Moutier, R; Reed, Terry; Busnel, Marie Claire; Marchaland, Catherine; Roubertoux, Pierre L.; Carlier, Michèle

doi:10.1007/bf02361159

Cited by 175 publications

(146 citation statements)

References 25 publications

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“…Twins' zygosity was determined primarily on the basis of self-report and four questionnaire items concerning how often twins were confused with each other and the similarity of their physical appearances. Previous studies have determined that such questions have high validity (greater then 90% accuracy) when compared to zygosity determinations based on DNA (Spitz et al 1996). In cases of uncertain zygosity determination, DNA was used to identify twins as MZ or DZ (Harris et al 2003).…”

Section: Methods Participantsmentioning

confidence: 99%

Alcohol Use in Adolescent Twins and Affiliation with Substance Using Peers

Hill

Emery

Harden

et al. 2007

J Abnorm Child Psychol

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Affiliation with substance using peers is one of the strongest predictors of adolescent alcohol use. This association is typically interpreted causally: peers who drink incite their friends to drink. This association may be complicated by uncontrolled genetic and environmental confounds because teens with familial predispositions for adolescent substance use may be more likely to select into social networks where drinking is common. We test this alternative hypothesis using a sample of 1,820 twin and sibling pairs, and their same-sex best friends, from three waves of the National Longitudinal Study of Adolescent Health. Across all three waves, peer report of substance use did not influence adolescent alcohol use when genetic and shared environmental predispositions for drinking were considered. The association between alcohol use and peer behavior may be a spurious association attributable to a shared genetic liability to drink alcohol and associate with peers who drink alcohol.

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Section: Methods Participantsmentioning

confidence: 99%

Alcohol Use in Adolescent Twins and Affiliation with Substance Using Peers

Hill

Emery

Harden

et al. 2007

J Abnorm Child Psychol

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“…For pairs whose answers contradicted each other, or who were unsure, zygosity was determined using additional questions and methods of classifying responses that have been shown to give 95% agreement with zygosity based on blood typing in middle-aged adults (11)(12)(13).…”

Section: Methodsmentioning

confidence: 99%

Mammographic Density and Candidate Gene Variants: A Twins and Sisters Study

Stone¹,

Gurrin²,

Byrnes³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Mammographic density, the light/white radiographic appearance on a mammogram that represents connective and epithelial tissue, is a strong risk factor for breast cancer which seems to be highly heritable. Little is known about its genetic determinants. Methods: We studied 457 women from 207 sisterhoods (104 monozygotic twins, 182 dizygotic twins, and 171 singletons). Percentage mammographic density (PMD) as well as dense area and nondense area were calculated using a computerassisted method. We measured six single nucleotide polymorphisms from six candidate genes (COMT, HSD3B1, IGFBP3, HER2, XPD, and XRCC3). Associations between genotypes and mammographic measures were tested (a) cross-sectionally using a multivariate normal model fitted

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“…Twin pair zygosity was confirmed by Յ12 highly polymorphic short tandem-repeats, with an accuracy of Ͼ99%. 23 …”

Section: Zygosity Testingmentioning

confidence: 99%

Effect of Birth Parameters on Retinal Vascular Caliber

et al. 2009

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Abstract-Recent studies reported an association between smaller birth size and narrower retinal vascular caliber, but it remains unclear whether this association is attributed to confounding by shared environment or genetic factors. At a mean age of 9.3 years, 266 twins (49 monozygotic and 84 dizygotic pairs) in the Twins Eye Study in Tasmania underwent an ophthalmic examination including retinal photography. Retinal vascular caliber was measured using a validated protocol. The majority of these twins were also in the Tasmanian Infant Health Study, which prospectively collected data on birth parameters and antenatal maternal factors. We conducted the main analysis using linear mixed models, accounting for birth set clustering. Key Words: twins Ⅲ epidemiology Ⅲ blood pressure Ⅲ arterioles Ⅲ birth weight Ⅲ birth length Ⅲ head circumference E vidence to support the hypothesis of the fetal origins of adult disease has accumulated in the last decade. 1,2 Widely reported data from epidemiological studies implicate adverse influence during fetal, infant, and early childhood growth that might ultimately lead to the early onset of cardiovascular diseases, hypertension, and diabetes. 3 The specific mechanisms underlying these associations, however, are far from clear.Study of retinal microvascular changes attributed to fetal and perinatal influences offers a unique opportunity to uncover the underlying causal pathways of fetal origins of adulthood vasculopathies. Using new computer-based retinal imaging techniques, we have shown that precisely measured retinal arteriolar narrowing is a strong marker for the development of hypertension and cardiovascular events, including myocardial infarction. 4 -6 New studies now demonstrate that lower birth weight is associated with narrower retinal arterioles, 7,8 narrower bifurcation angle, 9 higher retinal vessel tortuosity, and optimality deviance, 10 providing initial evidence that fetal origins of cardiovascular disease may partly be mediated by the microcirculation. However, it could be argued that the association between birth weight and microvascular alternation may be confounded by genetic or shared environmental factors (eg, maternal nutrition) that affect both birth size and abnormal microvascular structural development. It is also commonly understood that variation in almost all human traits and diseases has some genetic component, and this is evident for retinal vascular caliber 11,12 and size at birth. 13

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Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis

Cited by 175 publications

References 25 publications

Alcohol Use in Adolescent Twins and Affiliation with Substance Using Peers

Alcohol Use in Adolescent Twins and Affiliation with Substance Using Peers

Mammographic Density and Candidate Gene Variants: A Twins and Sisters Study

Effect of Birth Parameters on Retinal Vascular Caliber

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