Abstract:Background: Early detection of colorectal cancer (CRC) is essential to reduce cancer-related morbidity and mortality. Stool DNA (sDNA) testing is an emerging method for early CRC detection. Syndecan-2 (SDC2) methylation is a potential biomarker for the sDNA testing. Aberrant DNA methylation is an early epigenetic event during tumorigenesis, and can occur in the normal colonic mucosa during aging, which can compromise the sDNA test results. This study aimed to determine whether methylated SDC2 in sDNA normalize… Show more
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