Comparative Depression of Several Short Acting Barbiturates and Spiro-Barbiturates

Under catalysis of 10 mol % of Et3N, the [3 + 2] cycloaddition of barbiturate-based olefins with 3-isothiocyanato oxindoles underwent smoothly and afforded the desired dispirobarbiturates in up to 99% yield with up to 99:1 dr. The relative configuration of the dispirobarbiturates was unambiguously determined by X-ray single-crystal structure analysis. The reaction mechanism was proposed to shed light on the diastereoselective formation of the dispirobarbiturates.

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Comparative Depression of Several Short Acting Barbiturates and Spiro-Barbiturates

Abstract: In an effort to develop new and possibly better types of barbiturates, suitable for intravenous use, a large number of spiro-barbiturates have been

Cited by 5 publications

References 1 publication

Asymmetric Construction of Highly Functionalized Spirobarbiturate‐Cyclopentenes through Chiral Phosphine‐Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Barbiturate‐Derived Alkenes

Asymmetric Construction of Highly Functionalized Spirobarbiturate‐Cyclopentenes through Chiral Phosphine‐Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Barbiturate‐Derived Alkenes

High diastereoselective synthesis of spiro-barbituratechromans via domino oxa-Michael/1,6-addition reactions of ortho-hydroxyphenylsubstituted para-quinone methides with barbiturate-based olefins

Diastereoselective Synthesis of Dispirobarbiturates through Et₃N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles

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Comparative Depression of Several Short Acting Barbiturates and Spiro-Barbiturates

Abstract: In an effort to develop new and possibly better types of barbiturates, suitable for intravenous use, a large number of spiro-barbiturates have been

Cited by 5 publications

References 1 publication

Asymmetric Construction of Highly Functionalized Spirobarbiturate‐Cyclopentenes through Chiral Phosphine‐Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Barbiturate‐Derived Alkenes

Asymmetric Construction of Highly Functionalized Spirobarbiturate‐Cyclopentenes through Chiral Phosphine‐Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Barbiturate‐Derived Alkenes

High diastereoselective synthesis of spiro-barbituratechromans via domino oxa-Michael/1,6-addition reactions of ortho-hydroxyphenylsubstituted para-quinone methides with barbiturate-based olefins

Diastereoselective Synthesis of Dispirobarbiturates through Et3N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles

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Diastereoselective Synthesis of Dispirobarbiturates through Et₃N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles