Comparative cytotoxicity analyses of disinfection byproducts in drinking water using dimensionless parameter scaling method: Effect of halogen substitution type and number

Lu, Jinhua; Luo, Jiayi; Wei, Wenzhe; Song, Meirong; Shi, Wei; Li, Aimin; Zhou, Qing; Pan, Yang

doi:10.1016/j.watres.2023.120087

Cited by 10 publications

(1 citation statement)

References 48 publications

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“…Halobenzoquinones (HBQs) have emerged as a DBP detected in potable water in recent years [ 11 , 12 ]. Toxicological studies have shown that HBQs are more cytotoxic and genotoxic than regulated DBPs [ 13 , 14 ]. HBQs can also induce the production of intracellular reactive oxygen species, which reduces the antioxidant enzyme activity of cells, leading to oxidative DNA damage [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

A ng/L Level LC-MS Method Using Membrane SPE as Sampling Technology: Determination of Nine Halobenzoquinones in Potable Water

Huang,

Zhou,

et al. 2024

Molecules

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A promising method was established for the determination of nine halobenzoquinones (HBQs) in potable water by membrane solid-phase extraction (MSPE) pretreatment and the liquid chromatography–mass spectrometry (LC-MS) method. A 500 mL water sample was taken for enrichment by the SDB-RPS membrane, which was previously activated by methanol and ultrapure water. The sample was eluted with methanol and re-dissolved with the initial mobile phase after nitrogen blowing. Then, it was detected in negative ion mode using the working curve, and HBQs were quantified by the external standard method. The linearity was satisfactory in the concentration range of 4-1000 ng/L, with correlation coefficients of 0.9963~0.9994. The recoveries were 73.5~126.6% at three spiked levels, with relative standard deviations (RSDs) of 6.8~15.5%. The limits of detection (LOD, S/N = 3) values were 0.1~0.7 ng/L. The results demonstrate that the MSPE-LC-MS method is reliable, rapid, and sensitive for the simultaneous analysis of nine HBPs in potable water.

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