Comparative cytotoxic study of silica materials functionalised with essential oil components in HepG2 cells

Fuentes, Cristina; Ruiz-Rico, María; Fuentes, Alfonso; Baviera, José Manuel Barat; Ruiz, María José

doi:10.1016/j.fct.2020.111858

Cited by 13 publications

(13 citation statements)

References 55 publications

(66 reference statements)

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“…The toxicological effects of vanillin are reported less than those of other EOCs. It is considered to have a low cytotoxic potential as only high concentrations (mM range) reduce cell viability in a concentration-and time-dependent manner (Oliveira et al 2014;Fuentes et al 2021). Additionally, vanillin is not considered harmful by ingestion, with an LD 50 of 3978 mg/kg bw for acute oral exposure and a NOAEL value of 650 mg/kg/day, as determined by a subchronic study in rats (ECHA 2021).…”

Section: Vanillinmentioning

confidence: 99%

Relevant essential oil components: a minireview on increasing applications and potential toxicity

Fuentes

Baviera

et al. 2021

Toxicology Mechanisms and Methods

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Phenolic compounds carvacrol, thymol, eugenol, and vanillin are four of the most thoroughly investigated essential oil components given their relevant biological properties. These compounds are generally considered safe for consumption and have been used in a wide range of food and non-food applications. Significant biological properties, including antimicrobial, antioxidant, analgesic, antiinflammatory, anti-mutagenic, or anti-carcinogenic activity, have been described for these components. They are versatile molecules with wide-ranging potential applications whose use may substantially increase in forthcoming years. However, some in vitro and in vivo studies, and several case reports, have indicated that carvacrol, thymol, and eugenol may have potential toxicological effects. Oxidative stress has been described as the main mechanism underlying their cytotoxic behavior, and mutagenic and genotoxic effects have been occasionally observed. In vivo studies show adverse effects after acute and prolonged carvacrol and thymol exposure in mice, rats, and rabbits, and eugenol has caused pulmonary and renal damage in exposed frogs. In humans, exposure to these three compounds may cause different adverse reactions, including skin irritation, inflammation, ulcer formation, dermatitis, or slow healing. Toxicological vanillin effects have been less reported, although reduced cell viability after exposure to high concentrations has been described. In this context, the possible risks deriving from increased exposure to these components for human health and the environment should be thoroughly revised.

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Section: Vanillinmentioning

confidence: 99%

Relevant essential oil components: a minireview on increasing applications and potential toxicity

Fuentes

Baviera

et al. 2021

Toxicology Mechanisms and Methods

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“…Interestingly, the kinetics of drug release could be controlled by varying the pH of the environments. Fuentes et al demonstrated that a bare MCM-41 particle exhibited mild cytotoxicity toward HepG2 cells (Fuentes et al 2021), showing the feasibility of being used in medical fields. They also showed that the cytotoxicity of the MCM-41 composite would be affected by the functional groups; thus, it could be easily tuned.…”

Section: Mesoporous Silicamentioning

confidence: 99%

Advanced Ordered Nanoporous Materials

Kadja

Nurdini

Krisnandi

et al. 2021

Advanced Functional Porous Materials

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Ordered nanoporous materials have attracted much attention due to their unique pore architecture, tunable physicochemical properties, which find applications in a broad spectrum of catalysis, separation, adsorption, drug delivery, energy storage, and sensing. In the past decades, the amount of research on ordered nanoporous materials has grown incrementally, resulting in diverse types of these materials with unprecedented structures. Herein, this chapter presents the recent advances of ordered nanoporous materials, including zeolites, ordered mesoporous materials (OMMs), metal-organic frameworks (MOFs), and covalent organic frameworks (COFs). Several vital aspects, i.e., structural and physicochemical properties,

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“…In vitro experiments have demonstrated the antibacterial effect of vanillin on different food-related bacteria, yeast, and molds [ 22 , 23 ]. Moreover, the lower cytotoxicity of vanillin as compared to other phenolic compounds has been reported, indicating its potential as a safe antimicrobial agent [ 24 ]. Given its natural origin and effective antibacterial properties, vanillin holds significant promise for the control of E. coli O157:H7 in the food industry.…”

Section: Introductionmentioning

confidence: 99%