Comparative corneal topography and refractive variables in monozygotic and dizygotic twins

Valluri, Shailaja; Minkovitz, Jeffrey B.; Budak, Koray; Essary, Lydia R.; Walker, R. Scott; Chansue, Ekktet; Cabrera, G.M; Koch, Douglas D.; Pepose, Jay S.

doi:10.1016/s0002-9394(98)00319-5

Cited by 39 publications

(30 citation statements)

References 20 publications

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“…98 All of these studies found significant differences in the intrapair correlations for spherical refractive errors between monozygotic and dizygotic twins, suggesting that genetic influences on myopia and hyperopia are strong. The correlations between monozygotic twins for astigmatism were not significantly different from the correlations between dizygotic twins in these studies.…”

Section: Genetics and Astigmatismmentioning

confidence: 99%

“…Several studies comparing monozygotic and dizygotic twins have investigated the genetic influence on astigmatic refractive errors, [96][97][98][99] including Teikari and O'Donnell, 96 Teikari and associates 97 and Valluri and colleagues. 98 All of these studies found significant differences in the intrapair correlations for spherical refractive errors between monozygotic and dizygotic twins, suggesting that genetic influences on myopia and hyperopia are strong.…”

Section: Genetics and Astigmatismmentioning

confidence: 99%

“…99,100 Other studies favour a stronger environmental influence. [96][97][98]101 It would appear that both genetic and environmental factors have roles in the development of astigmatism. The exact nature of these mechanisms is still not fully understood.…”

Section: Genetics and Astigmatismmentioning

confidence: 99%

See 2 more Smart Citations

A review of astigmatism and its possible genesis

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Collins

Carney

2007

Clinical and Experimental Optometry

229

205

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Astigmatism is a refractive condition encountered commonly in clinical practice. This review presents an overview of research that has been carried out examining various aspects of this refractive error. We examine the components of astigmatism and the research into the prevalence and natural course of astigmatic refractive errors throughout life. The prevalence of astigmatism in various ethnic groups and diseases and syndromes is also discussed. We highlight the extensive investigations that have been conducted into the possible aetiology of astigmatism, however, no single model or theory of the development of astigmatism has been proven conclusively. Theories of the development of astigmatism based on genetics, extraocular muscle tension, visual feedback and eyelid pressure are considered. Observations and evidence from the literature supporting and contradicting these hypotheses are presented. Recent advances in technology such as wavefront sensors and videokeratoscopes have led to an increased understanding of ocular astigmatism and with continued improvements in technology, our knowledge of astigmatism and its genesis should continue to grow.

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Section: Genetics and Astigmatismmentioning

confidence: 99%

Section: Genetics and Astigmatismmentioning

confidence: 99%

See 1 more Smart Citation

A review of astigmatism and its possible genesis

Read

Collins

Carney

2007

Clinical and Experimental Optometry

229

205

View full text Add to dashboard Cite

show abstract

“…23,24 Valluri et al reported a stronger role of environment factors in development of astigmatism. 10 There have been conflicting data about the association of increased percentage of astigmatism in infants with prematurity or low birth weight, and with retinopathy of prematurity, but the association of height, weight, and astigmatism have not been described in preschool children. Some but not all studies find higher rates of astigmatism among subjects with ametropia in either the myopic or hyperopic direction, particularly for higher magnitude spherical refractive errors.…”

Section: Discussionmentioning

confidence: 99%

“…9 Valluri et al reported a stronger role of environment factors. 10 In a study by Dobson et al, against the rule (ATR) astigmatism was 2.5 times more common than with the rule (WTR) in children younger than 3.5 yrs of age. 4 In contrast, WTR Astigmatism was 3 times more common in children older than 5.5 yrs.…”

Section: Introductionmentioning

confidence: 97%

Profile of astigmatism in school going children at state level hospital in Uttarakhand

Gupta¹,

Vats²,

Tyagi³

2016

Int J Res Med Sci

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Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population

et al. 2018

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Refractive errors, myopia, and hyperopia are common visual disorders greatly affecting older individuals. Refraction is determined by genetic factors but only a small percentage of its variation has been explained. We performed a genetic association analysis with three ocular phenotypes: spherical equivalent (a continous measure of refraction), axial length, and corneal curvature in 1,871 European-Americans from the Beaver Dam Eye Study. Individuals were genotyped on the Illumina exome array and imputed to the Haplotype Reference Consortium reference panel. After increasing the number of analyzed variants in targeted protein-coding regions 10-fold via imputation, we confirmed associations for two previously known loci with corneal curvature (chr4q12, rs2114039; g.55092626T > C, β = -0.03 (95% confidence interval [CI]): -0.06, -0.01, P value = 0.01) and spherical equivalent (chr15q14, rs634990; g.35006073T > C, β = -0.27, 95% CI: -0.45, -0.09, P value = 3.79 × 10 ). Despite increased single nucleotide polymorphism (SNP) density, we did not detect any novel significant variants after correction for multiple comparisons. In summary, we confirmed two previous loci associated with corneal curvature and spherical equivalent in a European-American population highlighting the potential biological role of those regions in these traits.

show abstract

Comparative corneal topography and refractive variables in monozygotic and dizygotic twins

Cited by 39 publications

References 20 publications

A review of astigmatism and its possible genesis

A review of astigmatism and its possible genesis

Profile of astigmatism in school going children at state level hospital in Uttarakhand

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population

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