Comparative Content of Neuron-Specific Enolase in Human Blood Serum and Seminal Plasma

Sosnin, D. Yu.; Gal’kovich, K. R.; Khovaeva, Ya. B.; Гильманов, А. Ж.

doi:10.1007/s10517-022-05537-9

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In clinical diagnosis, an elevated tumor marker concentration is an early indicator for monitoring tumor progression and detecting recurrence or metastasis. Many biomarkers associated with cancer have been found and can be used for cancer diagnosis, such as carcinoembryonic antigen (CEA) [3][4][5][6][7], alpha-fetoprotein (AFP) [8,9], prostate-specific antigen (PSA) [10], carbohydrate antigen (CA) [11,12], neuron-specific enolase (NSE) [13], etc.…”

Section: Introductionmentioning

confidence: 99%

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Zhang

Gan

et al. 2023

Sensors

View full text Add to dashboard Cite

Tumor markers are important substances for assessing cancer development. In recent years, RNA tumor markers have attracted significant attention, and studies have shown that their abnormal expression of post-transcriptional regulatory genes is associated with tumor progression. Therefore, RNA tumor markers are considered as potential targets in clinical diagnosis and prognosis. Many studies show that biosensors have good application prospects in the field of medical diagnosis. The application of biosensors in RNA tumor markers is developing rapidly. These sensors have the advantages of high sensitivity, excellent selectivity, and convenience. However, the detection abundance of RNA tumor markers is low. In order to improve the detection sensitivity, researchers have developed a variety of signal amplification strategies to enhance the detection signal. In this review, after a brief introduction of the sensing principles and designs of different biosensing platforms, we will summarize the latest research progress of electrochemical, photoelectrochemical, and fluorescent biosensors based on signal amplification strategies for detecting RNA tumor markers. This review provides a high sensitivity and good selectivity sensing platform for early-stage cancer research. It provides a new idea for the development of accurate, sensitive, and convenient biological analysis in the future, which can be used for the early diagnosis and monitoring of cancer and contribute to the reduction in the mortality rate.

show abstract