Comparative clinicopathological characteristics of colon and rectal T1 carcinoma

Abstract

Abstract. Lymph node metastasis significantly influences the management of patients with colorectal carcinoma. It has been observed that the biology of colorectal carcinoma differs by location. The aim of the current study was to retrospectively compare the clinicopathological characteristics of patients with colon and rectal T1 carcinomas, particularly their rates of lymph node metastasis. Of the 19,864 patients who underwent endoscopic or surgical resection of colorectal neoplasms at Showa University Northern Yokohama Hospital, 557 had T1 surgically resected carcinomas, including 457 patients with colon T1 carcinomas and 100 patients with rectal T1 carcinomas. Analysed clinicopathological features included patient age, gender, tumor size, morphology, tumor budding, invasion depth, vascular invasion, histological grade, lymphatic invasion and lymph node metastasis. Rectal T1 carcinomas were significantly larger than colon T1 carcinomas (mean ± standard deviation: 23.7±13.1 mm vs. 19.9±11.0 mm, P<0.01) and were accompanied by significantly higher rates of vascular invasion (48.0% vs. 30.2%, P<0.01). Significant differences were not observed among any other clinicopathological factors. In conclusion, tumor location itself was not a risk factor for lymph node metastasis in colorectal T1 carcinomas, even though on average, rectal T1 carcinomas were larger and accompanied by a significantly higher rate of vascular invasion than colon T1 carcinomas.

Left-sided location is a risk factor for lymph node metastasis of T1 colorectal cancer: a single-center retrospective study

“…In addition, female sex and the status of the muscularis mucosae were also reported as risk factors [ 22 , 31 – 33 ]. Regarding location, there have been several reports comparing the rectum and colon, which showed that the rate of LNM was equivalent or higher in the rectum [ 15 , 16 ]. The current study dividing the tumor location into the left- and right-side is the largest study of T1 CRC.…”

“…Many studies have investigated the differences in epidemiology, pathogenesis, genetic alterations, and molecular pathways between left-and right-sided advanced CRC, as well as those that divided the location of CRC into the colon and rectum [14][15][16]. However, few articles have focused on the differences in early-(T1) stage disease and divided the tumor location into the left-and right-sided colon.…”

Prognostic value of nuclear FBI‑1 in patients with rectal cancer with or without preoperative radiotherapy

“…A possible reason for this discrepancy may be the sample investigated, since all samples from the present study were RC samples; however previous studies have included rectal and colon cancer samples. Increasing evidence reported that RC possesses numerous molecular markers and some characteristics of colon cancer (26,27). Another possible reason may be the aberrant transport process of FBI-1 protein from the cytoplasm to the nucleus, which requires further investigation.…”

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion

“…With recent advances in endoscopic treatments, such as ESD, many T1 CRCs can be resected endoscopically with negative margin. Although endoscopic treatment is an attractive option for the patients, T1 CRCs show approximately 10% of LNM, which requires surgical colectomy with lymph node dissection to cure the cancer (13)(14)(15)(16)(17)(18)(19)(20). Therefore, it is important to reveal the risk factors for LNM in the patients with T1 CRCs, and we should decide whether additional surgery after endoscopic resection is needed according to the presence of risk factors for LNM.…”