Comparative Clinical Study of Ofloxacin and Cefaclor in Bacterial Bronchitis

Fujimori, Ippei; Kobayashi, Yoshio; Obana, Mitsuo; Saitô, Atsushi; Tomizawa, M.; Nakayama, Ichiro; Hiraga, Y.; Kikuchi, Kohki; Yamamoto, Asako; Takebe, Kazuo

doi:10.11150/kansenshogakuzasshi1970.58.832

Cited by 15 publications

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The Role of the Fluoroquinolones

Guay

1992

Pharmacotherapy

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Over the past decade, the quinolone antimicrobial class has enjoyed a renaissance with the emergence of the fluoroquinolone subclass. Norfloxacin, ciprofloxacin, ofloxacin, enoxacin, and lomefloxacin have the advantages of broad antimicrobial activity profiles including gram‐positive and ‐negative aerobes, favorable pharmacokinetic profiles including substantial oral bioavailability and extensive tissue distribution, and in general, favorable safety profiles. As clinical experience accumulates, our understanding of their optimum roles will become more refined. In six instances, these agents may be preferred over currently available agents: complicated urinary tract infections, empiric therapy of suspected bacterial gastroenteritis, eradication of the Salmonella carrier state, respiratory exacerbations due to Pseudomonas aeruginosa in patients with cystic fibrosis, invasive external otitis, and chronic gram‐negative bacillary osteomyelitis. The efficacy and convenience of these agents for the treatment of a broad range of infections have already resulted in their extensive use. Such use carries the risk of selection pressure for the development of resistance and the adverse consequences of increased cost over less expensive, equally effective alternatives. The use of the fluoroquinolones should focus on infections where there is demonstrated benefit of these agents over conventional agents or infections for which there are few or no alternatives.

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The Role of the Fluoroquinolones

Guay

1992

Pharmacotherapy

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The top 50 drugs in the UK and Japan: why are they so different?

Hirokawa¹,

Dollery²

1994

The Relevance of Ethnic Factors in the Clinical Evaluation of Medicines

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Dokumentation und Bewertung von Arzneimittelnebenwirkungen am Beispiel des Ofloxacins

et al. 1991

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A systematical and comprehensive evaluation of all reports on adverse drug reactions ascribed to ofloxacin since this antibiotic was launched (1985) until October 1988 shows that rare and severe adverse drug reactions are more often reported spontaneously than in the course of clinical trials. In particular, severe reductions of white blood cell counts, shock and shock fragments, and impairment of sensory organs and renal functions have for the first time been detected by spontaneous case reports. The results demonstrate exemplarily the potency of the spontaneous reporting system as superior to that of clinical trials in providing information on rare adverse drug reactions.

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Comparative Clinical Study of Ofloxacin and Cefaclor in Bacterial Bronchitis

Cited by 15 publications

References 1 publication

The Role of the Fluoroquinolones

The Role of the Fluoroquinolones

The top 50 drugs in the UK and Japan: why are they so different?

Dokumentation und Bewertung von Arzneimittelnebenwirkungen am Beispiel des Ofloxacins

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