Comparative clinical evaluation of freeze‐dried skin allografts and autogenous gingival grafts in humans*

Abstract

Freeze-dried skin (FDS) allografts and fresh autogenous free gingival grafts (FGG) were placed in five paired sites in four patients. Both types of grafts healed uneventfully. Evaluation over a 1-year period demonstrated no statistically or clinically significant differences between the FDS and FGG when: a) increase in the width of keratinized gingiva, b) decrease in recession, c) decrease in sulcus depth, k) gain in attachment level, or e) percent shrinkage of the graft were compared. It was concluded that FDS performs essentially similar to FGG in the correction of mucogingival problems, and has the advantages of decreased patient morbidity (no donor site) and availability of abundant amounts of graft material when needed.

Free Gingival Grafts: Graft Shrinkage and Donor‐Site Healing in Smokers and Non‐Smokers

“…In the present study the average FGG thickness was 1.5 mm for both smokers and non‐smokers and within a narrowly controlled range. Hatipoğlu et al 21 used grafts within this standard, but other studies included thinner grafts 14,18,39 or did not report on FGG thickness 12,15‐17,19,20 . When FGG is placed on a periosteal bed, FGG shrinkage is mostly attributable to loss of vestibular depth, caused by cicatricial contraction 16,21 .…”

“…The free gingival graft (FGG) is a surgical technique introduced more than 40 years ago to address the lack of keratinized tissue 9‐11 . The FGG has been, and continues to be, the subject of extensive research focusing on either the graft itself 12‐21 or the donor site 19,22‐24 . Although other techniques, such as the subepithelial connective tissue graft, 22‐24 are now more widely used for root coverage procedures, the FGG is still commonly used to increase keratinized tissue dimensions.…”

A comparative clinical evaluation of acellular dermal matrix allograft and sub-epithelial connective tissue graft for the treatment of multiple gingival recessions

“…Based on the reports of ADMA, matrix would revascularize via preserved vascular channel and that it would integrate into the host tissue. [2223] At the same time, ADMA may also act as a barrier equivalent to selective cell repopulation membrane, thus encouraging periodontal-guided tissue regeneration. The observed clinical changes probably represent a combination of new connective tissue attachment in the apical half of the defect and the presence of long junctional epithelial attachment in the coronal half.…”

Clinical Human Comparison of Expanded Polytetrafluoroethylene Barrier Membrane and Freeze‐Dried Dura Mater Allografts for Guided Tissue Regeneration of Lost Periodontal Support. I. Mandibular Molar Class II Furcations

“…25,29 Freeze-dried skin and FDDMA allografts are composed mainly of collagen and have been shown to be acceptable and beneficial when used intra-orally. 1,13,14,16,[42][43][44][45][46][47][48] of freeze-dried skin allograft as a biologic bandage covering surgically traumatized alveolar bone has demonstrated supracrestal cementogenesis and an increased amount of connective tissue attachment to the surgically exposed roots when compared with routine flap replacement.1 Additional advantages to the use of allogeneic freeze-dried skin or dura mater, or other freeze-dried soft tissues, are the availability of large amounts of donor tissue for multiple sites, the ease of storage in vacuum bottles at room temperature, and virtual absence of immunogenicity. [49][50][51] The objective of this study was to clinically compare the use of e-PTFE and freeze-dried dura mater allografts (FDDMA) as a biologic cover over Class II furcation osseous defects in mandibular molars.…”