Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis

Korolyova-Ushakova, A.G.; Baranova, E. V.; Ignatov, Sergei G.; Soloviev, P V; Kondakov, N. N.; Mel'nikova, T. M.; Abronina, Polina I.; Podval’nyi, N. M.; Kononov, L. O.; Biketov, S F

doi:10.1134/s0003683819060097

Cited by 10 publications

(2 citation statements)

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“…Due to the critical roles of AG and LAM in infectivity and pathogenicity of Mycobacterium tuberculosis , their structural motifs are currently attracting unprecedented attention for the study of pathways of biosynthesis of these glycopolymers, [3] the development of diagnostics [4] and vaccines, [5] as well as new effective antimicrobial drugs. It should be noted that neoglycoconjugates based on the terminal branched hexasaccharide fragment (Ara 6 ) containing two β‐(1→2)‐linked d ‐arabinofuranose residues, common for AG and LAM arabinan domains, with mycobacterial recombinant proteins as well as neoglycoconjugates, based on synthetic fragments of LAM and carbohydrate epitopes of mycobacterial glycolipid PGL‐1, with bovine serum albumin (BSA) are promising for the diagnosis of tuberculosis and leprosy [4c–e] . Besides, gold nanoparticles were successfully used as a support, to which the branched Ara 6 hexasaccharide was attached [4b] …”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that chemical synthesis of di‐ and tetraarabinofuranoside fragments 2 and 3 of M. tuberculosis arabinans with 4‐(3‐azidopropoxy)phenyl (APP) aglycone is essential for further preparation of conjugates as antigens, useful for effective diagnosis of mycobacterioses. Previously, it was shown that a BSA conjugate of disaccharide 1 containing a homologous 4‐(2‐azidoethoxy)phenyl (AEP) aglycone is promising for the development of mycobacteriosis serodiagnostic tools [4e] …”

Section: Introductionmentioning

confidence: 99%

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Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

et al. 2022

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Formation of 1,2‐trans‐arabinofuranoside linkage in arabinans from Mycobacterium tuberculosis using differently protected Ara‐β‐(1→2)‐Ara disaccharide glycosyl donors in the absence of a participating group at O‐2 was studied. The influence of the nature of the protective and leaving groups in glycosyl donors on the efficiency and stereoselectivity of the 1,2‐trans‐arabinofuranosylation was investigated. The efficiency of Ara‐β‐(1→2)‐Ara p‐tolyl thioglycoside containing five triisopropylsilyl groups in 1,2‐trans‐stereoselective synthesis of a protected tetrasaccharide corresponding to a fragment of the M. tuberculosis arabinan was shown for the first time. On the contrary, the use of glycosyl donors based on Ara‐β‐(1→2)‐Ara containing only benzoyl or both silyl and benzoyl groups led to the loss of stereocontrol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

et al. 2022

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Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

Harvey

2023

Mass Spectrometry Reviews

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This review is the tenth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2020. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. The review is basically divided into three sections: (1) general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, quantification and the use of arrays. (2) Applications to various structural types such as oligo‐ and polysaccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals, and (3) other areas such as medicine, industrial processes and glycan synthesis where MALDI is extensively used. Much of the material relating to applications is presented in tabular form. The reported work shows increasing use of incorporation of new techniques such as ion mobility and the enormous impact that MALDI imaging is having. MALDI, although invented nearly 40 years ago is still an ideal technique for carbohydrate analysis and advancements in the technique and range of applications show little sign of diminishing.

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The use of silyl groups in the synthesis of arabinofuranosides

2022

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Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis

Cited by 10 publications

References 43 publications

Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

The use of silyl groups in the synthesis of arabinofuranosides

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