Comparative characteristics of COVID-19 vaccines used for mass immunisation

Онищенко, Г. Г.; Сизикова, Т. Е.; Лебедев, В. Н.; Борисевич, С. В.

doi:10.30895/2221-996x-2021-21-3-158-166

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…Для снижения этого риска в аденовирусных вакцинах часто используются разные векторы для основной и дополнительной доз, например, в вакцине "Sputnik V" (Ad26 и Ad5). Такой подход позволяет минимизировать влияние предсуществующего иммунитета, обеспечивая эффективность вакцины [37]. В таблице 1 представлена сравнительная характеристика наиболее применяемых вакцин против вируса SARS-CoV-2.…”

Section: таблица 1 сравнительная характеристика наиболее часто примен...unclassified

“…4. Генетический материал вакцин на основе аденовирусов относительно стабилен, что упрощает их производство и хранение по сравнению с другими вакцинными платформами, например, мРНКвакцинами, которые требуют жестких условий хранения в холодовой цепи [37].…”

Section: таблица 1 сравнительная характеристика наиболее часто примен...unclassified

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Booster vaccination against the SARS-CoV-2: mechanisms and efficiency

Berns,

Veremeyev,

Savicheva

et al. 2024

Cardiovasc Ther Prev

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Coronavirus disease 2019 (COVID-19) pandemic was not only a serious challenge for the healthcare system around the world, but also an incentive for intensive research and development for the introduction of innovative technologies and drugs, in particular vaccines against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2). The first vaccination campaigns provided significant protection against severe disease course and hospitalization. However, new SARS-COV-2 variants require further comprehensive research and the introduction of booster vaccination. Booster vaccination is the most important tool for immunostimulation and increase of protection duration against the severe disease course. The study of booster vaccines, including BioNTech/Pfizer, Moderna, Oxford AstraZeneca, Sputnik V, Sinopharm и Covaxin vaccines, sheds light on their unique action mechanisms and contribution to long-term immunity. The analysis of clinical data demonstrates their effectiveness and safety. The review summarizes modern knowledge about booster vaccinations against the COVID-19 with focus on action mechanisms and efficiency. In addition, the immune system function in response to COVID-19 is considered, while the role of memory cells, antibody and cellular immunity reactions are emphasized.

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Section: таблица 1 сравнительная характеристика наиболее часто примен...unclassified

Booster vaccination against the SARS-CoV-2: mechanisms and efficiency

Berns,

Veremeyev,

Savicheva

et al. 2024

Cardiovasc Ther Prev

View full text Add to dashboard Cite

show abstract

“…Тем самым формируется пласт невосприимчивых к повторному инфицированию лиц (пассивный, естественный путь) и через иммунизацию населения (активный, искусственный путь). По мнению исследователей, нет различий в том, каким образом достигается необходимый порог: естественным путем (переболевшие COVID-19) или искусственным (лица, прошедшие курс вакцинации) [3][4][5].…”

Section: результатыunclassified

Creation of collective immune as the main preventive measure for the spread of the new coronavirus infection (COVID-19)

Tovanova¹

2022

Vestnik SPbSU. Medicine

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Achieving the required level of herd immunity against a new coronavirus infection (COVID-19) in order to protect the population is an urgent issue in preventive and practical medicine around the world. Herd immunity is an indirect indicator of protection against COVID-19 disease and is made up of the immunity of individuals in a particular group. Epidemiological monitoring of the structure, formation, and dynamics of herd immunity will make it possible to correctly and timely adjust approaches to anti-epidemic measures, both in individual risk groups, in particular among medical workers, and in society as a whole. The required level of herd immunity against a new coronavirus infection can be achieved naturally, after a disease, or artificially, through mass immunization of the population. To date, vaccination is the safest, most effective, and most cost-effective method. Serological research methods (detection of IgG) indicate the effectiveness of vaccination — the formation of post-vaccination immunity or a past disease. Determining the period of time at which a stable antibody titer is determined, as well as their level, is essential for predicting morbidity.

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A Clinical Case of Adverse Events After Immunization Against a New Coronavirus Infection

Gabbasova,

Mamchik,

Yatsenko

et al. 2023

Bulletin of the Central Chernozem Region

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A 20-year-old girl was immunized against COVID-19 with Sputnik V. 6 hours after vaccination, symptoms of intoxication, body aches, weakness appeared, body temperature increased to 40.3С during the day, pain was noted at the injection site. The post-vaccination reaction lasted 2 days. The patient did not seek medical attention. The girl received the second dose of the vaccine on the 21st day after the first vaccination. 6 hours after immunization, symptoms of intoxication, body aches, weakness appeared, body temperature increased to 40.6C, pain was noted at the injection site. The next day she asked for medical help at the clinic, diagnosed with: Post-vaccination reaction to the Sputnik-V vaccine; symptomatic therapy was prescribed. The body temperature was 37.0-38.0C for 2 weeks. Despite the superstrong general post-vaccination reaction, revaccination was carried out six months later. After the introduction of the vaccine, the body temperature increased to 41.6C, there were pronounced symptoms of intoxication, body aches, weakness, at the injection site - hyperemia, soreness, swelling of more than 8 cm in diameter. The next day, the student asked for medical help, an infectious disease doctor diagnosed her with an allergic reaction to the Sputnik V, Sputnik Light vaccine, and symptomatic treatment was prescribed. Body temperature remained febrile for 6 days, general symptoms persisted for 2 weeks, and local reactions persisted for 3 weeks.

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Comparative characteristics of COVID-19 vaccines used for mass immunisation

Cited by 9 publications

References 29 publications

Booster vaccination against the SARS-CoV-2: mechanisms and efficiency

Booster vaccination against the SARS-CoV-2: mechanisms and efficiency

Creation of collective immune as the main preventive measure for the spread of the new coronavirus infection (COVID-19)

A Clinical Case of Adverse Events After Immunization Against a New Coronavirus Infection

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