Comparative bioavailability of two sertraline tablet formulations after single-dose administration in healthy Thai volunteers

Analytical methodologies for the determination of sertraline

“…Later, Tassaneeyakul et al compare the bio-availability of two SRT tablet (50 mg) formulations in 24 healthy Thai male volunteers under fasting condition. Plasma concentrations of SRT were determined using validated LC-MS/MS method [61].…”

PharmGKB summary: sertraline pathway, pharmacokinetics

“…Sertraline is slowly absorbed, with peak concentrations (C max ) occurring at 4-10 hours following ingestion, and has a half-life of 24-32 hours in children, adolescents and adults [11][12][13][14][15][16][17][18][19][20]. The therapeutic concentration range for sertraline has not been well established, but has been proposed to be 10-150 ng/mL [21].…”