Comparative Bioavailability of a Novel Fixed‐dose Combination Etoricoxib and Tramadol
Lourdes Garza‐Ocañas,
Christian T. Badillo‐Castaneda,
Sandra L. Montoya Eguía
et al.
Abstract:Multimodal analgesia is defined as using several drugs or techniques simultaneously to target different pain pathways or receptors to avoid pain propagation. This study evaluated the pharmacokinetic profile and comparative bioavailability of etoricoxib 90 mg and tramadol 50 mg dosing alone (reference drugs) or in a novel fixed‐dose combination (test drug) under fasting conditions in Mexican healthy volunteers. This was a randomized, open‐label, 3‐way, crossover, single‐dose, prospective, and longitudinal study… Show more
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