Comparative Benefits and Harms of Second-Generation Antidepressants: Background Paper for the American College of Physicians

Abstract

Current evidence does not warrant the choice of one second-generation antidepressant over another on the basis of differences in efficacy and effectiveness. Other differences with respect to onset of action and adverse events may be relevant for the choice of a medication.

Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression

“…SSRIs primarily enhance serotonin neurotransmission whereas bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with minimal (or no) direct effects on serotonin (Baldessarini, 2006). Similar antidepressant efficacy of these drugs (Thase et al, 2005;Gartlehner et al, 2008;Cipriani et al, 2009), and their relative safety on overdose, facilitates comparison of effects on suicidal ideation or behavior.…”

Evidence-based choice and antidepressants treatment in psychiatry

“…Хотя лечение СИОЗС по данным рандомизированных клиниче-ских исследований лучше переносится (реже риск обрыва терапии) в разных возрастных группах [22][23][24][25], чем ТЦА, выбор первых может повышать риск некоторых побочных эффектов. Но различный про-филь нежелательных действий отдельных СИОЗС [26] позволяет индивидуализированный их выбор. Дозозависимые желудочно-кишечные расстройства при использовании СИОЗС обычно преходящи и отмечаются только в первые недели [23].…”

“…Действенность всех классов антидепрессантов при остром и длительном лечении сходна [20,22,26]. Считается, что ТЦА более показаны больнич-ным пациентам.…”

Comparing the Efficacy of 8 Week Treatment of Cipram® and its Generic Citalopram in Patients with Mixed Anxiety-Depressive Disorder

“…The mainstay of pharmacotherapy in this disorder consists of combination of antidepressants and anxiolytics (5). Because of their better tolerability (6), similarity in terms of efficacy and better safety in overdose, second-generation antidepressants including Selective Serotonin Reuptake Inhibitors (SSRIs) have gradually substituted tricyclic antidepressants (TCAs) since mid-1980s and became the first-line medications for the treatment of depression (7). In fact the introduction of SSRIs was the beginning of a great therapeutic era in psychopharmacology (8).…”