Comparative behaviour of the components of the factor VIII complex in acute myocardial infarction

Cucuianu, M; Cristea, Anca; Roman, S; Rus, Horea; Missits, Ileana; Pechet, Liberto

doi:10.1016/0049-3848(83)90183-4

Cited by 20 publications

(13 citation statements)

References 15 publications

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“…Consequently, we also quantified vWF:Ag, which is usually considered as a marker of vascular injury. In agreement with previous studies [38,39], we observed an increase of vWF, but this increase did not discriminate between patients with a good or poor prognosis.…”

Section: Discussionsupporting

confidence: 94%

Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction

Dreden

Rousseau

Savouré

et al. 2009

Blood Coagulation &Amp; Fibrinolysis

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Several studies have indicated an association between haemostatic markers and acute myocardial infarction, but few or no studies refer to their activity. We studied plasma levels of 10 coagulation factors (fibrinogen, protein C, protein S, von Willebrand factor, D-dimers, factor VIIa, free tissue factor pathway inhibitor, tissue-type plasminogen activator, plasminogen activator inhibitor-1, thrombomodulin) and using new specific assays analysed the activity of plasma tissue factor (TFa), thrombomodulin (TMa), and procoagulant phospholipid in 46 consecutive patients with acute myocardial infarction at the time of hospital admission, and compared them with 34 healthy normal volunteers. Plasma levels of TFa, TMa, and procoagulant phospholipid were significantly higher in cases than in control patients (P < 0.001). In addition the ratio of TFa/free tissue factor pathway inhibitor was higher in patients than in controls, whereas the tissue-type plasminogen activator (t-PA)/plasminogen activator inhibitor-1 ratio was lower in patients. Interestingly, patients with an unfavourable outcome during a 2-month follow-up had higher levels of TFa, TMa, procoagulant phospholipid, a higher ratio of TFa/free tissue factor pathway inhibitor and a lower ratio of t-PA/plasminogen activator inhibitor-1 than patients who recovered. The combination of these different parameters reveals an increase in procoagulant activity as well as impaired fibrinolytic activity during the acute phase of an acute myocardial infarction. The association of the level of the activity of these three factors may provide a new tool to assess the prognosis of acute myocardial infarction. Further studies are needed to support our findings and to elucidate the clinical interest of measuring these factors.

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Section: Discussionsupporting

confidence: 94%

Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction

Dreden

Rousseau

Savouré

et al. 2009

Blood Coagulation &Amp; Fibrinolysis

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“…In patients with vascular diseases or denudation of the endothelium and exposed subendothelium (e.g. in myocardial infarction, acute respiratory failure, acute and chronic renal insufficiency, hypertension, diabetic nephropathy, vasculitis) [5, 28, 29, 30, 31, 32, 33]vWf is regarded as a marker of endothelial dysfunction [34]. …”

Section: Discussionmentioning

confidence: 99%

Expression of von Willebrand Factor by Human Pulmonary Endothelial Cells in vivo<footref rid="foot01"><sup>1</sup></footref>

et al. 2002

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Background and Objectives: Whether von Willebrand factor (vWf) is variably expressed by endothelial cells (EC) of the human vascular tree or not is not known. Studies on animals showed that the varying degrees of vWf expression in pulmonary vessels was a reflection of EC heterogeneity. Neither the influence of age or sex nor that of pathophysiological factors such as pulmonary hypertension (PH) on vWf expression has been systematically analysed up to now. However, such information is essential for the design and delivery of site-selective drugs and genes as well as for the analysis of EC culture systems. Methods: The variable degrees of vWf expression in lung tissue specimens from 64 patients (age: 6 weeks to 86 years) with and without PH were studied immunohistochemically and analysed statistically. Results: CD31-specific antibody was used as a control stain for EC. It produced equally strong staining reactions in all pulmonary EC. In contrast, vWf-specific antibody yielded negative or weakly positive staining reactions in capillary EC. The staining intensities increased hand in hand with vessel calibres. Besides, they increased statistically significantly with age and PH. Sex had no influence on vWf expression. Conclusion: These findings show that (1) vWf expression by pulmonary EC is heterogeneous and specific for individual types of vessels, (2) age and PH enhance vWf expression, (3) vWf expression is indicative of altered EC activation but not of EC defects, and (4) elevated plasma levels of vWf correlate positively with raised coagulatory activities in older patients and in patients with PH.

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“…8 Subsequently, several investigators found that vWF was high in an array of clinical situations, all characterized by vascular damage with denudation of the endothelium and exposure of the subendothelium (for instance, acute respiratory failure, acute and chronic renal insufficiency, hypertension, diabetic nephropathy, and vasculitis). [23][24][25][26][27][28][29] To interpret these findings, it has been postulated that in patients with large-and small-vessel disease, the membranes of damaged endothelial cells would "leak" vWF, leading to an increase of the plasma levels of this protein. Clinicians became attracted by this simple approach to the evaluation of the degree of endothelial damage in vascular disease, because it reminded them of the usefulness and widespread adoption in clinical practice of the measurement of serum enzymes to evaluate the degree of hepatic and cardiac cell damage.…”

Section: Vwf: a Marker Of Endothelial Damage?mentioning

confidence: 99%

von Willebrand Factor

Mannucci

1998

ATVB

197

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Comparative behaviour of the components of the factor VIII complex in acute myocardial infarction

Cited by 20 publications

References 15 publications

Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction

Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction

Expression of von Willebrand Factor by Human Pulmonary Endothelial Cells in vivo<footref rid="foot01"><sup>1</sup></footref>

von Willebrand Factor

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