Comparative Assessment of the Treatment of Type 2 Diabetes Mellitus

Kokić, Slaven; Radman, Miroslav; Čapkun, Vesna; Dovzak-Kokić, Djurdja; Tešanović, Sanda

doi:10.5144/0256-4947.2002.163

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…This also applies to cardiovascular death, coronary heart disease and stroke. 1 – 5 Transcranial Doppler sonography (TCD) is a modern and sophisticated diagnostic procedure that enables visualization of hemodynamic changes in the basal cerebral arteries in real time and the recording of changes in cerebral perfusion in various physiological and pathophysiological states. 6 – 11 TCD is a highly sensitive and specific method for quick bedside assessment of cerebrovascular circulation hemodynamics.…”

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confidence: 99%

Transcranial Doppler ultrasound assessment of intracranial hemodynamics in patients with type 2 diabetes mellitus

Dikanović

Hozo

Kokić

et al. 2005

Annals of Saudi Medicine

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BACKGROUNDDiabetics have a 3-fold risk for cardiovascular diseases compared with non-diabetics. This study was designed to evaluate cerebral hemodynamic changes related to type 2 diabetes mellitus (DM) with transcranial Doppler ultrasonography (TCD). TCD is a highly sensitive and specific method of quick bedside assessment of cerebrovascular circulation hemodynamics.PATIENTS AND METHODSIn a prospective study, we compared a group of 100 patients with the diagnosis of type 2 diabetes mellitus (aged 48 to 67 years) and an age- and sex-matched control group of 100 healthy subjects without diabetes mellitus. We measured flow velocities (Vm) and the Gosling pulsatility index (PI) of the middle cerebral artery (MCA).RESULTSThe rate of TCD abnormalities was significantly higher in diabetic patients than in healthy control subjects (55% vs. 11%, P<0.05). The PI was significantly higher in diabetic patients than in healthy controls (P<0.001). Atherosclerotic changes were found in 34.0% and 71.4% of patients suffering from diabetes for <5 and ≥5 years, respectively.CONCLUSIONThis study suggests that TCD is a useful marker for the detection of diabetic cerebrovascular changes. The duration and type of diabetes were found to have an impact on the development of pathologic cerebrovascular changes.

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confidence: 99%

Transcranial Doppler ultrasound assessment of intracranial hemodynamics in patients with type 2 diabetes mellitus

Dikanović

Hozo

Kokić

et al. 2005

Annals of Saudi Medicine

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“…T2DM is mainly characterized by elevated blood sugar, which can damage insulin signaling and cause insulin resistance. 2 Clinically, insulin injections or oral hypoglycemic drugs are typically used to control the development of T2DM, 3 but new hypoglycemic drugs are needed.…”

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confidence: 99%

Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

Zhu

Liu

et al. 2020

Diabetes and Vascular Disease Research

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Aims: The objective of this study was to explore the effects of epigallocatechin-3-gallate (EGCG) on type 2 diabetes mellitus (T2DM). Main methods: Male Sprague–Dawley rats were allocated into six groups. The control group received a conventional diet. The diabetic group received a high-sucrose high-fat (HSHF) diet for 4 weeks and then was fasted and injected with streptozotocin (STZ); subsequently, the rats received a HSHF diet for another 4 weeks to develop diabetes. The four treatment groups were diabetic rats that received intragastric metformin (500 mg/kg/day) or EGCG (25, 50, and 100 mg/kg/day) for 10 weeks. All groups except the control group received a HSHF diet throughout the experiment. Several biochemical parameters such as fasting blood glucose (FBG), postprandial blood glucose (PBG), liver glycogen, muscle glycogen, fasting serum insulin (FSI), homeostasis model of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFA), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured to assess the effects of EGCG on glycemic control, insulin resistance, lipid profile, and oxidative stress. Furthermore, oxidative stress in pancreatic islet β cells was detected by dihydroethidium staining. Key findings: A HSHF diet and STZ injection induced T2DM, as indicated by changed blood glucose and body weight, which was accompanied by insulin resistance, an altered lipid profile, and oxidative stress. Interestingly, EGCG treatment dose-dependently recovered these indexes. Significance: EGCG successfully ameliorated glycemic control and insulin sensitivity while reducing the lipid profile and oxidative stress in a T2DM rat model.

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Comparative Assessment of the Treatment of Type 2 Diabetes Mellitus

Cited by 2 publications

References 27 publications

Transcranial Doppler ultrasound assessment of intracranial hemodynamics in patients with type 2 diabetes mellitus

Transcranial Doppler ultrasound assessment of intracranial hemodynamics in patients with type 2 diabetes mellitus

Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

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