Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericum perforatum extract on induced oral mucositis in golden hamsters

Tanideh, Nader; Namazi, Fatemeh; Andisheh-Tadbir, Azadeh; Ebrahimi, Hooman; Koohi-Hosseinabadi, Omid

doi:10.1016/j.ijom.2014.05.013

Cited by 28 publications

(28 citation statements)

References 20 publications

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“…The incidence of UC has been reported about [10][11][12][13][14][15][16][17][18][19][20] per 1000000 per year with a prevalence of 100-200 per 1000000 in Western countries (3). In addition, a persistent UC can increase the risk of development of colorectal cancer by ~10 folds (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Tanideh¹,

Nematollahi²,

Hosseini³

et al. 2014

Ann Colorectal Res

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Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD). There are several chemical and herbal drug regimens for treatment of UC. Objectives: The aims of this study were to investigate the effects of Hypericum perforatum on histopathological and tissue malondialdehyde (MDA) level of colonic tissue in rat with induced UC. Materials and Methods: Two milliliters of 3% acetic acid was administered into the colon to induce UC. Seventy rats were divided into seven equal groups. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V as positive control received 2 mL of intra-colonic asacol; group VI was a negative control receiving 0.5 mL/kg of normal saline after induction of UC; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level seven days after the treatment. Results: H. perforatum extract in the two forms of trans-rectal and oral administration on the seventh day after the therapy could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel form had a better healing response than the 10% gel form and was prominently more effect on the seventh day of the therapy. In oral administration of strawberry extract, the 600 mg/kg dosage had a better healing response than the 300 mg/kg and was significantly more effective on the seventh day of therapy. Conclusions: So H. perforatum may be considered as a treatment of choice for UC especially in gel form to broaden the current therapy options of the disease.

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Section: Introductionmentioning

confidence: 99%

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Tanideh¹,

Nematollahi²,

Hosseini³

et al. 2014

Ann Colorectal Res

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“…This was due to the healing effect of borneol which promoted greater formation of fibroblasts with better collagen and fibronectin production in local lesions (Figure 9). Tanideh et al (2014) also observed increased stimulation of collagen production by topical gel Hypericum perforatum L., which helped repair the wounds, closing areas of damaged oral mucosa in the animals. This effect may be associated with the bactericidal action of borneol, which prevents secondary infection by fungi and bacteria, promoting reepithelialization and standardization of collagen fiber content (Tabanca et al, 2001;Wenqiang et al, 2006).…”

Section: 4% (14 Days) (Mann-whitney Test)mentioning

confidence: 77%

“…The G4 Group (Control) received topical application with distilled water. After the application, all animals were prevented from drinking water or eating for 30 minutes to allow time for the gels to act (Tanideh et al, 2014). The treatments were administered from the third to 13th day after injury with acetic acid.…”

Section: Treatment Subgroupsmentioning

confidence: 99%

“…The Control Group and Borneol 0% groups, at seven days, showed a much more intense inflammatory process than the treated groups (Borneol 1.2% and Borneol 2.4%), but Page 7 / 10 (2013), in which the authors confirmed the action of monoterpene and suggested that the substance has therapeutic potential in painful and inflammatory diseases. Tanideh et al (2014) tested the action of Hypericum perforatum L. extract for treating induced oral mucositis in animals. The extract of this plant contains Borneol (CIV, 2012) and was administered by gavage (systemically) and locally via an oral gel.…”

Section: 4% (14 Days) (Mann-whitney Test)mentioning

confidence: 99%

“…Rich have been used to treat oral mucositis with satisfactory results (Rodriguez-Caballero et al, 2012;Freitas, Rodrigues, Gaspi, 2014.). Chamomile has been used in the treatment of OM with promising results (Dos Braga et al, 2015;Curra et al, 2013;Pavesi et al, 2011) Also, Hypericum perforatum L. extract, whose phytocomplex contains borneol, has shown antiinflammatory and healing action in oral mucositis animal models both systemically and locally through oral gel (Tanideh et al, 2014). Borneol ( Figure 1) is a monoterpene, bicyclic aromatic alcohol, present in many essential oils of medicinal plants of the Dipterocarpaceae, Lamiaceae (Rosmarinus officinalis L., Thymus vulgaris L. and Salvia officinalis L.) (Dipterocarpus turbinatus Gaertn.)…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory and healing action of oral gel containing borneol monoterpene in chemotherapy-induced mucositis in rats ( Rattus norvegicus )

Júnior

Brito

Barros

et al. 2017

Braz. J. Pharm. Sci.

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The aim of this study was to investigate the effect of gels containing the monoterpene borneol in induced oral mucositis using an animal model. Gels were prepared with borneol at 1.2% and 2.4% (w/w). Oral mucositis was induced by administration of three doses of 5-fluorouracil (30 mg/kg, i.p.) and injury with acetic acid (50%, v/v) soaked in filter paper applied to right cheek mucosa for 60s. Four subgroups comprising 12 animals each were formed. Six animals from each group were sacrificed at days seven and fourteen after oral mucositis induction. Mucous samples were processed and stained with hematoxylineosin and Masson's Trichrome. The semiquantitative evaluation involved observation of inflammatory parameters. ImageJ® software was used in the quantitative evaluation. For statistical analyses, Two-way ANOVA, followed by Tukey's post-test (p <0.05), were employed. Borneol 2.4% gel proved effective in the treatment of oral mucositis with statistically significant differences between groups for angiogenesis control, inflammatory cell count reduction and percentage neoformed collagen increase. The confirmation of anti-inflammatory and healing action of borneol in oral mucositis in rats renders it a good marker for predicting this activity for plant extracts rich in this substance.

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The pathogenesis of mucositis: updated perspectives and emerging targets

Bowen

Al‐Dasooqi²,

Bossi

et al. 2019

Support Care Cancer

121

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Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group regularly assesses available literature relating to pathogenesis, mechanisms, and novel therapeutic approaches and distils this to summary perspectives and recommendations. Reviewers assessed 164 articles published between January 2011 and June 2016 to identify progress made since the last review and highlight new targets for further investigation. Findings were organized into sections including established and emerging mediators of toxicity, potential insights from technological advances in mucositis research, and perspective. Research momentum is accelerating for mucositis pathogenesis, and with this has come utilization of new models and interventions that target specific mechanisms of injury. Technological advances have the potential to revolutionize the field of mucositis research, although focused effort is needed to move rationally targeted interventions to the clinical setting.

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Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericum perforatum extract on induced oral mucositis in golden hamsters

Cited by 28 publications

References 20 publications

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Anti-inflammatory and healing action of oral gel containing borneol monoterpene in chemotherapy-induced mucositis in rats ( Rattus norvegicus )

The pathogenesis of mucositis: updated perspectives and emerging targets

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