Comparative Assessment of Selected Metals in the Scalp Hair and Nails of Lung Cancer Patients and Controls

Qayyum, Muhammad Abdul; Shah, Munir H.

doi:10.1007/s12011-014-9942-6

Cited by 19 publications

(14 citation statements)

References 46 publications

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“…It has also been shown that cadmium contained in tobacco smoke has an antagonistic effect on zinc which may lead to zinc level reduction (Unkiewicz-Winiarczyk et al 2009 ). In patients with prostate and lung cancers, Karimi et al ( 2012 ) as well as Qayyum and Shah ( 2014 ) have also shown higher zinc levels in the control group than in the cancer-affected group. Pasha et al ( 2010 ), in turn, have shown higher zinc values in patients with gastrointestinal cancers.…”

Section: Discussionmentioning

confidence: 94%

“…In our studies, the highest chromium (VI) concentration was obtained for laryngeal cancer patients, and the lowest level of this elements, showing a statistically significant difference compared to the control group, was found in tonsil cancer patients. Study by Qayyum and Shah ( 2014 ) has shown higher chromium concentrations in control group subjects than in lung cancer patients. Pasha et al ( 2007 ), in turn, have found a reverse correlation–cancer patients had higher levels of this metal than healthy individuals in the control group.…”

Section: Discussionmentioning

confidence: 98%

“…Cobalt is generally known to be a component of vitamin B12. In higher concentrations, however, it may be cancerogenic (Qayyum and Shah 2014 ). Inhaling cobalt in large amounts may cause damage, mainly to the lungs, leading to asthma, pneumonia, or lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Inhaling cobalt in large amounts may cause damage, mainly to the lungs, leading to asthma, pneumonia, or lung cancer. Cobalt’s cancerogenic properties are associated with its ability to inhibit repair mechanisms and to cause DNA damage (Qayyum and Shah 2014 ). The highest concentration of this metal has been noted in patients with neck tumor, the lowers in patients with mouth cancer–the difference was statistically significant compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Hair are primarily used in determination of elements and medicines content (organic substances, narcotic drugs, nicotine metabolites) (Chojnacka et al 2006 ). Their analysis allows evaluation of health and body nutrition (Qayyum and Shah 2014 ). Owing to their multiple advantages, hair samples are widely used to assess human exposure to various contaminations (Rodrigues et al 2008 ).…”

Section: Introductionmentioning

confidence: 99%

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Metal concentrations in hair of patients with various head and neck cancers as a diagnostic aid

et al. 2015

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Head and neck cancers are one of the most frequent cancers worldwide. This paper attempts to evaluate disturbances of homeostasis of the necessary elements (calcium, magnesium, zinc, copper, iron, manganese) and changes in the levels of toxic metals (lead, cadmium, cobalt, chromium VI) in hair of patients with head and neck cancers, as well as people without a diagnosed neoplastic disease. In order to quantify the necessary elements and toxic metals, a method using ICP-MS and ICP-OES techniques had been developed and validated. The studies have shown that patients with head and neck cancer used to drink alcohol and smoked much more frequently than healthy individuals, both in the past and presently. Statistically significant differences in concentrations of average metal content in the group of patients with head and neck cancers compared to the control group were confirmed. Significant differences in metal content between the group of patients with head and neck cancers and healthy individuals were found which enabled distinguishing between the study groups. To this end, a more advanced statistical tool, i.e. chemometrics, was used. The conducted research analyses and the use of advanced statistical techniques confirm the benefits of using alternative material to distinguish the patients with head and neck cancers from the healthy individuals.

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