Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status

Khojah, Hani M J; Ahmed, Sameh

doi:10.1177/0300060519882563

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…However, the development of certain fluorescence-based probes has facilitated such measurements [20]. Thus, a recent study assessed individual ROS and RNS in the sera of rheumatoid arthritis patients [21] and healthy subjects that were smokers [22]. However, most of the research on ROS and RNS in COVID-19 patients has been focused on measuring overall oxidative stress rather than examining individual ROS and RNS and their related pathogenic functions.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Serum Levels of Reactive Oxygen and Nitrogen Species on the Disease Severity of COVID-19

Ahmed

Alahmadi

Abdou³

2023

IJMS

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Elucidation of the redox pathways in severe coronavirus disease 2019 (COVID-19) might aid in the treatment and management of the disease. However, the roles of individual reactive oxygen species (ROS) and individual reactive nitrogen species (RNS) in COVID-19 severity have not been studied to date. The main objective of this research was to assess the levels of individual ROS and RNS in the sera of COVID-19 patients. The roles of individual ROS and RNS in COVID-19 severity and their usefulness as potential disease severity biomarkers were also clarified for the first time. The current case-control study enrolled 110 COVID-19-positive patients and 50 healthy controls of both genders. The serum levels of three individual RNS (nitric oxide (NO•), nitrogen dioxide (ONO−), and peroxynitrite (ONOO−)) and four ROS (superoxide anion (O2•−), hydroxyl radical (•OH), singlet oxygen (1O2), and hydrogen peroxide (H2O2)) were measured. All subjects underwent thorough clinical and routine laboratory evaluations. The main biochemical markers for disease severity were measured and correlated with the ROS and RNS levels, and they included tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), the neutrophil-to-lymphocyte ratio (NLR), and angiotensin-converting enzyme 2 (ACE2). The results indicated that the serum levels of individual ROS and RNS were significantly higher in COVID-19 patients than in healthy subjects. The correlations between the serum levels of ROS and RNS and the biochemical markers ranged from moderate to very strongly positive. Moreover, significantly elevated serum levels of ROS and RNS were observed in intensive care unit (ICU) patients compared with non-ICU patients. Thus, ROS and RNS concentrations in serum can be used as biomarkers to track the prognosis of COVID-19. This investigation demonstrated that oxidative and nitrative stress play a role in the etiology of COVID-19 and contribute to disease severity; thus, ROS and RNS are probable innovative targets in COVID-19 therapeutics.

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Section: Introductionmentioning

confidence: 99%

The Impact of Serum Levels of Reactive Oxygen and Nitrogen Species on the Disease Severity of COVID-19

Ahmed

Alahmadi

Abdou³

2023

IJMS

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“…One of these hypotheses states that nicotine stimulates the production and secretion of growth hormones, catecholamines and cortisol, which causes an increase in the serum concentrations of free fatty acids, which triggers the hepatic secretion of triglycerides and very-low-density lipoprotein (VLDL-C) [ 8 ]. In one study, Khojah and Ahmed found that smokers compared to non-smokers have higher levels of triglycerides, cholesterol, VLDL-C, low-density lipoprotein cholesterol (LDL-CHOL) and lower levels of high-density lipoprotein cholesterol (HDL-CHOL) [ 9 ]. The effects of chronic tobacco consumption (smoking and chewing) on the lipid profile of 75 individuals divided in three groups (I: non-smokers and non- chewers; II: smokers and non-chewers and III: chewers and non-smokers) were studied by Rao and Subash and the results showed that the levels of cholesterol, VLDL-C, LDL-CHOL and triglycerides were higher in group II and III compared to group I, and on the other hand, HDL-CHOL had decreased levels in the same groups of patients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Lipid Profile and Biochemical Parameters of COPD Patients in Relation to Smoking Status

et al. 2022

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Tobacco consumption is the most incriminated and studied risk factor for Chronic obstructive pulmonary disease (COPD), but other factors such as air pollution, are also linked to this disease. One of the known aspects of this chronic lung disease is that its occurrence is mainly due to the chronic inflammation of the airways. Lipid metabolism seems to be affected by smoking, with studies showing a correlation between this habit and high levels of triglycerides and low levels of high-density lipoprotein cholesterol (HDL-CHOL). Uric acid concentration is thought to reflect the antioxidative capacity of the body because it is the most abundant aqueous antioxidant. The aim of this study was to investigate the lipid profile and biochemical parameters of COPD patients in relation to smoking status. The present study was conducted between 2020 and 2021 in the Clinical Hospital of Pneumology in Iasi, Romania. Patients diagnosed with COPD (n = 52) were included and divided in three groups depending on their smoking status: non-smokers, smokers and ex-smokers. The obtained results show low correlations between COPD stages and serum uric acid concentrations (r = 0.4; p ˂ 0.05), smoking status (smoker/non-smoker/ex-smoker) and total serum cholesterol values (r = 0.45; p ˂ 0.05), but also between serum urea concentrations and the number of packs-years for the smoker/ex-smoker groups (r = 0.45, p ˂ 0.05). Smoking was associated with changes in the lipid profile of smokers and ex-smokers, along with increased low-density lipoprotein cholesterol (LDL-CHOL) and low serum uric acid values.

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Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status

Cited by 2 publications

References 48 publications

The Impact of Serum Levels of Reactive Oxygen and Nitrogen Species on the Disease Severity of COVID-19

The Impact of Serum Levels of Reactive Oxygen and Nitrogen Species on the Disease Severity of COVID-19

The Lipid Profile and Biochemical Parameters of COPD Patients in Relation to Smoking Status

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