Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications

Antoniac, Iulian Vasile; Adam, Răzvan; Biță, Ana-Iulia; Miculescu, Marian; Trante, Octavian; Petrescu, Ionuț Mircea; Pogarasteanu, Mark Edward

doi:10.3390/ma14010084

Cited by 38 publications

(35 citation statements)

References 38 publications

(57 reference statements)

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“…The results are given as average values ± standard deviation for the replicate measurements. Biodegradability is an important characteristic of materials considered for various biomedical applications (e.g., drug delivery applications), even more so in the case of implantable materials [44]. For dissolution to occur, such material (in our case, a hydrogel) must absorb the surrounding aqueous solvent and interact with water via charge interactions or hydrogen bonding mechanisms [45].…”

Section: Swelling and Mass Lossmentioning

confidence: 99%

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

et al. 2021

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This study presents the development and characterisation of two novel bioactive coatings deposited on TiAlV and AISI 316LVM substrates. The coatings were prepared using 3D printing and electrospinning. The 3D-printed coating consisted of the cellulose nanofibril suspension, alginate, and carboxymethylcellulose (CMC), while CMC and polyethylene oxide were used to prepare the electrospun coating. Both coatings were loaded with the antibiotic clindamycin (CLIN), which is a bacteriostatic lincosamide known for its activity against streptococci, staphylococci, pneumococci, Bacteroides species, and other anaerobes. Initial characterisation of the coatings was performed by attenuated total reflectance Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and atomic force microscopy. Furthermore, the contact angle measurements, swelling rate, and biodegradability of the coatings were investigated. The released concentration of CLIN in PBS (pH = 7.4 at 25 °C) was determined by UV-VIS spectrophotometry. The coatings’ biocompatibility was determined using an MTT (3(4,5 dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay using an osteoblast cell culture (hFOB 1.19, ATCC CRL 11372).

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Section: Swelling and Mass Lossmentioning

confidence: 99%

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

et al. 2021

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“…As temporary orthopedic implant materials, magnesium and its alloys have great advantages because of comparable mechanical properties and good biocompatibility with natural bone [1][2][3][4]. In addition, compared with other traditional implant materials, the degradability of magnesium alloy avoids the secondary removal of implants [5].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Hydroxyapatite Coating on AZ31 Magnesium Alloy Induced by Carboxymethyl Cellulose-Dopamine

Yang

Wei

et al. 2021

Materials

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Magnesium and its alloys have become potential implant materials in the future because of light weight, mechanical properties similar to natural bone, good biocompatibility, and degradability in physiological environment. However, due to the rapid corrosion and degradation of magnesium alloys in vivo, especially in the environment containing chloride ions, the application of magnesium alloys as implant materials has been limited. Therefore, improving the corrosion resistance of magnesium alloy and ensuring good biocompatibility is the main focus of the current research. In this study, hydroxyapatite coating was prepared on magnesium alloy surface using carboxymethyl cellulose-dopamine hydrogel as inducer to improve corrosion resistance and biocompatibility. Surface characterization techniques (scanning electron microscopy, Fourier-transformed infrared spectroscopy, energy dispersive X-ray spectroscopy- and X-ray diffraction) confirmed the formation of hydroxyapatite on the surface of AZ31 alloy. Corrosion resistance tests have proved the protective effect of Carboxymethyl cellulose-Dopamine/hydroxyapatite (CMC-DA/HA) coating on the surface of AZ31 alloy. According to MC3T3-E1 cell viability and Live/Dead staining, the coating also showed good biocompatibility. The results will provide new ideas for the biological application of magnesium alloys.

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“…Magnesium alloy is the lightest metal structure material in engineering application. It has broad application prospects in aerospace, automobile, and other fields due to its high specific strength, high specific stiffness, and good machinability [ 1 , 2 , 3 , 4 ]. However, the low absolute strength and plasticity of magnesium alloy has seriously restricted its wide application in industry [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Formation of 14H-LPSO in Mg–9Gd–2Y–2Zn–0.5Zr Alloy during Heat Treatment

Liu

Yang

et al. 2021

Materials

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There is a new long-period stacking ordered structure in Mg–RE–Zn magnesium alloys, namely the LPSO phase, which can effectively improve the yield strength, elongation, and corrosion resistance of Mg alloys. According to different types of Mg–RE–Zn alloy systems, two transformation modes are involved in the heat treatment transformation process. The first is the alloy without LPSO phase in the as-cast alloy, and the MgxRE phase changes to 14H-LPSO phase. The second is the alloy containing LPSO phase in the as-cast state, and the 14H-LPSO phase is obtained by the transformations of 6H, 18R, and 24R. The effects of different solution parameters on the second phase of Mg–9Gd–2Y–2Zn–0.5Zr alloy were studied by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The precipitation mechanism of 14H-LPSO phase during solution treatment was further clarified. At a solution time of 13 h, the grain size increased rapidly initially and then decreased slightly with increasing solution temperature. The analysis of the volume fraction of the second phase and lattice constant showed that Gd and Y elements in the alloy precipitated from the matrix and formed 14H-LPSO phase after solution treatment at 490 °C for 13 h. At this time, the hardness of the alloy reached the maximum of 74.6 HV. After solution treatment at 500 °C for 13 h, the solid solution degree of the alloy increases, and the grain size and hardness of the alloy remain basically unchanged.

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Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications

Cited by 38 publications

References 38 publications

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

Preparation and Characterization of Hydroxyapatite Coating on AZ31 Magnesium Alloy Induced by Carboxymethyl Cellulose-Dopamine

The Formation of 14H-LPSO in Mg–9Gd–2Y–2Zn–0.5Zr Alloy during Heat Treatment

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